Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
Public ClinicalTrials.gov record NCT07223593. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants With Peripheral Artery Disease: A Randomized, Double-Blind, Placebo Controlled Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the effect and safety of orforglipron once daily in participants with Fontaine II peripheral arterial disease (PAD). Participation in the study will last about 58 weeks.
Study identification
- NCT ID
- NCT07223593
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,205 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 30, 2025
- Primary completion
- May 31, 2028
- Completion
- May 31, 2028
- Last update posted
- Sep 7, 2026
2025 – 2028
United States locations
- U.S. sites
- 36
- U.S. states
- 14
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Vincent's Birmingham Hospital | Birmingham | Alabama | 35205 | Recruiting |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | Recruiting |
| Emvera Health at Peak Heart & Vascular Surprise | Surprise | Arizona | 85378 | Not yet recruiting |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | Recruiting |
| Angel City Research Inc. | Los Angeles | California | 90010 | Not yet recruiting |
| Valley Clinical Trials, LLC dba Flourish Research | Northridge | California | 91325 | Recruiting |
| The Cardiovascular Center | Redding | California | 96001 | Recruiting |
| InvivoCure | Van Nuys | California | 91405 | Recruiting |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | Recruiting |
| Rocky Mountain Regional VA Medical Center | Aurora | Colorado | 80045 | Not yet recruiting |
| Lakeview Institute of Clinical Research | Leesburg | Florida | 34748 | Recruiting |
| Inpatient Research Clinic | Miami Lakes | Florida | 33014 | Recruiting |
| Floridian Clinical Research, LLC | Miami Lakes | Florida | 33016-1518 | Recruiting |
| St Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | Recruiting |
| Guardian Research Organization, LLC | Winter Park | Florida | 32792 | Not yet recruiting |
| ASHA Clinical Research - Munster, LLC | Hammond | Indiana | 46324 | Recruiting |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | Recruiting |
| Cardiovascular Research of Northwest Indiana | Munster | Indiana | 46321 | Not yet recruiting |
| Deaconess Clinic- Gateway | Newburgh | Indiana | 47630 | Recruiting |
| Flourish Research - Bowie | Bowie | Maryland | 20715 | Recruiting |
| Capitol Cardiology Associates - Lanham Office | Lanham | Maryland | 20706 | Not yet recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | Recruiting |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | Recruiting |
| The Jackson Clinic | Jackson | Tennessee | 38305 | Recruiting |
| East Coast Institute for Research - Jefferson City | Jefferson City | Tennessee | 37760 | Recruiting |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | Recruiting |
| Research Physicians Network, LLC | Houston | Texas | 77089 | Recruiting |
| Sherman Clinical Research | Sherman | Texas | 75090 | Recruiting |
| NextStage Clinical Research - Waco | Waco | Texas | 76712 | Recruiting |
| Alpine Research Organization | Clinton | Utah | 84015 | Recruiting |
| Stroobants Cardiovascular Center | Lynchburg | Virginia | 24501 | Recruiting |
| Carient Heart & Vascular - Manassas | Manassas | Virginia | 20109 | Not yet recruiting |
| Clinical Research Partners, LLC | Richmond | Virginia | 23226 | Recruiting |
| Gershon Pain Specialists | Virginia Beach | Virginia | 23454 | Recruiting |
| ERA Health Research - CardioNow - Lynnwood | Lynnwood | Washington | 98036 | Recruiting |
| Eastside Research Associates | Redmond | Washington | 98052 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 125 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07223593, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 7, 2026 · Synced Sep 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07223593 live on ClinicalTrials.gov.