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Recruiting Phase 3 Interventional

A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis

ClinicalTrials.gov ID: NCT07225504

Public ClinicalTrials.gov record NCT07225504. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 3:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of Remibrutinib in Patients With Secondary Progressive Multiple Sclerosis

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to provide efficacy and safety data for remibrutinib in patients with secondary progressive multiple sclerosis (SPMS)

Study identification

NCT ID
NCT07225504
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
1,275 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years to 65 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 10, 2025
Primary completion
Dec 2, 2030
Completion
Jan 1, 2034
Last update posted
Jul 28, 2026

2025 – 2034

United States locations

U.S. sites
35
U.S. states
18
U.S. cities
31
Facility City State ZIP Site status
Alabama Neurology Associates PC Birmingham Alabama 35209 Recruiting
Ctr for Neurology and Spine Phoenix Arizona 85018 Recruiting
AZ Integrated Neuro and Spine Phoenix Arizona 85037 Recruiting
Center for Neurosciences Tucson Arizona 85718 Recruiting
Fullerton Neuro and Headache Ctr Fullerton California 92835 Recruiting
Regina Berkovich MD PhD Inc West Hollywood California 90048 Recruiting
UC Health Neuroscience Ctr Aurora Colorado 80045 Recruiting
Georgetown University Hospital Washington D.C. District of Columbia 20007 Recruiting
Medstar Washington Hosp Ctr Washington D.C. District of Columbia 20010 Recruiting
Neurology of Central FL Res Ctr Altamonte Springs Florida 32714 Recruiting
UF Health Cancer Center Gainesville Florida 32610 Recruiting
Homestead Assoc In Research Inc Homestead Florida 33033 Recruiting
Neurology Associates PA Maitland Florida 32751 Recruiting
Miami NS Ins Baptist Health S FL Miami Florida 33176 Recruiting
Aqualane Clinical Research Naples Florida 34105 Recruiting
Orlando Health Clinical Trials Orlando Florida 32806 Recruiting
Comprehensive Neurology Clinic Orlando Florida 32825 Recruiting
Neurology Associates of Ormond Beach Ormond Beach Florida 32174 Recruiting
Axiom Brain Health Tampa Florida 33609 Recruiting
University Of South Florida Tampa Florida 33612 Recruiting
Joi Life Wellness Group LLC Smyrna Georgia 30080 Recruiting
Hawaii Pacific Neuroscience LLC Honolulu Hawaii 96817 Recruiting
Northwestern Memorial Hospital Chicago Illinois 60611 Recruiting
University of Kansas Hospital Kansas City Kansas 66160 Recruiting
Mid Atlantic Epilepsy and Sleep Ctr Bethesda Maryland 20817-1807 Recruiting
Neuro Institute of New England P C Foxborough Massachusetts 02035 Recruiting
Elliot Lewis MS Center Wellesley Massachusetts 02481 Recruiting
U Mass Memorial Medical Center Worchester Massachusetts 01605 Recruiting
Michigan Institute of Neurological Farmington Hills Michigan 48334 Recruiting
University of New Mexico Hospital Albuquerque New Mexico 87106 Recruiting
Premier Neurology Greenville South Carolina 29605 Recruiting
Neurology Clinic PC Cordova Tennessee 38018 Recruiting
Carum Research Dallas Texas 75231 Recruiting
Saturn Research Solution Plano Texas 75024 Recruiting
Citta Clinical Research Spokane Washington 99202 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 221 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07225504, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 28, 2026 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07225504 live on ClinicalTrials.gov.

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