A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis
Public ClinicalTrials.gov record NCT07225504. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled Phase III Study to Evaluate the Efficacy and Safety of Remibrutinib in Patients With Secondary Progressive Multiple Sclerosis
Study identification
- NCT ID
- NCT07225504
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 1,275 participants
Conditions and interventions
Interventions
- Placebo Drug
- Remibrutinib (Open label) Drug
- Remibrutinib (blinded) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 10, 2025
- Primary completion
- Dec 2, 2030
- Completion
- Jan 1, 2034
- Last update posted
- Apr 23, 2026
2025 – 2034
United States locations
- U.S. sites
- 22
- U.S. states
- 13
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Neurology Associates PC | Birmingham | Alabama | 35209 | Recruiting |
| AZ Integrated Neuro and Spine | Phoenix | Arizona | 85037 | Recruiting |
| Center for Neurosciences | Tucson | Arizona | 85718 | Recruiting |
| Fullerton Neuro and Headache Ctr | Fullerton | California | 92835 | Recruiting |
| Regina Berkovich MD PhD Inc | West Hollywood | California | 90048 | Recruiting |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Neurology of Central FL Res Ctr | Altamonte Springs | Florida | 32714 | Recruiting |
| UF Health Cancer Center | Gainesville | Florida | 32610 | Recruiting |
| Neurology Associates PA | Maitland | Florida | 32751 | Recruiting |
| Aqualane Clinical Research | Naples | Florida | 34105 | Recruiting |
| Orlando Health Clinical Trials | Orlando | Florida | 32806 | Recruiting |
| Comprehensive Neurology Clinic | Orlando | Florida | 32825 | Recruiting |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | Recruiting |
| Axiom Brain Health | Tampa | Florida | 33609 | Recruiting |
| Joi Life Wellness Group LLC | Smyrna | Georgia | 30080 | Recruiting |
| Hawaii Pacific Neuroscience LLC | Honolulu | Hawaii | 96817 | Recruiting |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | Recruiting |
| Mid Atlantic Epilepsy and Sleep Ctr | Bethesda | Maryland | 20817-1807 | Recruiting |
| Michigan Institute of Neurological | Farmington Hills | Michigan | 48334 | Recruiting |
| Neurology Clinic PC | Cordova | Tennessee | 38018 | Recruiting |
| Saturn Research Solution | Plano | Texas | 75024 | Recruiting |
| Citta Clinical Research | Spokane | Washington | 99202 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07225504, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07225504 live on ClinicalTrials.gov.