A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Public ClinicalTrials.gov record NCT07225946. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Open-label Study of Pasritamig (JNJ-78278343), a T-cell-engaging Agent Targeting Human Kallikrein 2, With Docetaxel Versus Docetaxel for Metastatic Castration-resistant Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to find out whether treatment with pasritamig and docetaxel prolongs radiographic progression free survival (rPFS) (the length of time from start of treatment until disease worsens as determined by scans or death due to any cause) when compared to treatment with docetaxel in participants with metastatic castrate-resistant prostate cancer (mCRPC; a cancer of prostate, a male reproductive gland found below the bladder, that grows despite low levels of male hormones).
Study identification
- NCT ID
- NCT07225946
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 800 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 18, 2025
- Primary completion
- Nov 18, 2027
- Completion
- Jul 19, 2029
- Last update posted
- Aug 27, 2026
2025 – 2029
United States locations
- U.S. sites
- 53
- U.S. states
- 27
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Clinical Trials | Chandler | Arizona | 85225 | Recruiting |
| Arkansas Urology | Little Rock | Arkansas | 72211 | Recruiting |
| MemorialCare Orange Coast Medical Center | Fountain Valley | California | 92708 | Recruiting |
| University Of California San Diego | La Jolla | California | 92037 | Recruiting |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Recruiting |
| Kaiser Permanente Southern California | Riverside | California | 92505 | Recruiting |
| Sharp Center for Research | San Diego | California | 92123 | Recruiting |
| Providence Saint John s Health Center | Santa Monica | California | 90404 | Recruiting |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | Recruiting |
| Vail Health Shaw Cancer Center | Edwards | Colorado | 81632 | Recruiting |
| Grand Valley Oncology | Grand Junction | Colorado | 81505 | Recruiting |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | Recruiting |
| AdventHealth Orlando | Orlando | Florida | 32803 | Recruiting |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | Recruiting |
| Winship Cancer Institute Emory University | Atlanta | Georgia | 30322 | Recruiting |
| Duly Health and Care | Lisle | Illinois | 60532 | Recruiting |
| Cancer Center of Kansas Heritage Plaza Medical Building | Wichita | Kansas | 67214 | Recruiting |
| St Elizabeth Healthcare | Edgewood | Kentucky | 41017 | Recruiting |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | Recruiting |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | Recruiting |
| University of Maryland | Baltimore | Maryland | 21201 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| Johns Hopkins Medical Institutions | Baltimore | Maryland | 21287 | Recruiting |
| Chesapeake Urology Research Associates | Towson | Maryland | 21204 | Recruiting |
| Profound Research LLC at Cancer and Leukemia Center | Sterling Heights | Michigan | 48314 | Recruiting |
| HealthPartners Frauenshuh Cancer Center CRC West | Saint Louis Park | Minnesota | 55426 | Recruiting |
| HealthPartners Cancer Center at Regions Hospital CRC East | Saint Paul | Minnesota | 55101 | Recruiting |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | Recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| NHO Revive Research Institute, LLC | Lincoln | Nebraska | 68506 | Recruiting |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | Recruiting |
| Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | Recruiting |
| NYU Langone Health Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | Recruiting |
| Montefiore Medical Center | The Bronx | New York | 10461 | Recruiting |
| University of Cincinnati | Cincinnati | Ohio | 45219 | Recruiting |
| Oregon Urology Institute | Springfield | Oregon | 97477 | Recruiting |
| Lehigh Valley Hospital | Allentown | Pennsylvania | 18103 | Recruiting |
| MidLantic Urology | Bala-Cynwyd | Pennsylvania | 19004 | Recruiting |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | Recruiting |
| University Of Pittsburgh Medical Center UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Avera Medical Group | Sioux Falls | South Dakota | 57105 | Recruiting |
| Tennessee Cancer Specialists | Knoxville | Tennessee | 37909 | Recruiting |
| Texas Oncology | Austin | Texas | 78731 | Recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Houston Metro Urology | Houston | Texas | 77027 | Recruiting |
| Texas Oncology 1 | Sugar Land | Texas | 77479 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Fred Hutch Cancer Center Sloan Clinic 2 | Seattle | Washington | 98109 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 99 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07225946, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07225946 live on ClinicalTrials.gov.