Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma

ClinicalTrials.gov ID: NCT07226453

Public ClinicalTrials.gov record NCT07226453. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:45 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Target Validation and Efficacy Study of Metformin in Patients With Recurrent or Progressive Posterior Fossa Group A (PFA) Ependymoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.

Study identification

NCT ID: NCT07226453
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of California, San Francisco; Other
Enrollment: 30 participants

Conditions and interventions

Conditions

Posterior Fossa Ependymal Tumor

Interventions

Metformin Drug
Planned Surgical Resection Procedure
Magnetic Resonance Imaging (MRI) Procedure
Specimen Collection Procedure
MR spectroscopy (MRS) Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: 1 Year to 39 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 5, 2026 (Actual)
Primary completion: Apr 30, 2028 (Estimated)
Completion: Mar 31, 2030 (Estimated)
Last update posted: Oct 14, 2026

2026 – 2030

United States locations

U.S. sites: 12
U.S. states: 12
U.S. cities: 12

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Recruiting
Riley Hospital for Children at Indiana University Health	Indianapolis	Indiana	46202	Not yet recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Not yet recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Hackensack Meridian Health	Hackensack	New Jersey	07601	Not yet recruiting
Duke University	Durham	North Carolina	27710	Recruiting
St. Jude Children's Research Hospital	Memphis	Tennessee	38105	Not yet recruiting
University of Utah	Salt Lake City	Utah	84113	Recruiting
Seattle Children's Hospital University of Washington	Seattle	Washington	98101	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07226453, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 14, 2026 · Synced Oct 19, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07226453 live on ClinicalTrials.gov.

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