Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma
Public ClinicalTrials.gov record NCT07226453. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Target Validation and Efficacy Study of Metformin in Patients With Recurrent or Progressive Posterior Fossa Group A (PFA) Ependymoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-site study of the pharmacodynamic effects and efficacy of metformin in children and young adults with recurrent or progressive Posterior Fossa Group A (PFA) ependymoma.
Study identification
- NCT ID
- NCT07226453
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 30 participants
Conditions and interventions
Conditions
Interventions
- Metformin Drug
- Planned Surgical Resection Procedure
- Magnetic Resonance Imaging (MRI) Procedure
- Specimen Collection Procedure
- MR spectroscopy (MRS) Procedure
Drug · Procedure
Eligibility (public fields only)
- Age range
- 1 Year to 39 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 4, 2026
- Primary completion
- Apr 29, 2028
- Completion
- Mar 30, 2030
- Last update posted
- Aug 23, 2026
2026 – 2030
United States locations
- U.S. sites
- 10
- U.S. states
- 10
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94143 | Recruiting |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | Not yet recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| Hackensack Meridian Health | Hackensack | New Jersey | 07601 | Not yet recruiting |
| Duke University | Durham | North Carolina | 27710 | Recruiting |
| St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | Not yet recruiting |
| University of Utah | Salt Lake City | Utah | 84113 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07226453, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 4, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07226453 live on ClinicalTrials.gov.