A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

ClinicalTrials.gov ID: NCT07226895

Public ClinicalTrials.gov record NCT07226895. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 17, 2026, 3:18 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Study to Explore Changes in Cognitive, Clinical, Biological and Digital Measures Following 8 Weeks of Twice-daily Dosing of MT1988 and to Evaluate Safety & Tolerability of MT1988, in Participants at Clinical High Risk (CHR) for Psychosis

Study identification

NCT ID: NCT07226895
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Monument Therapeutics Limited; Industry
Enrollment: 150 participants

Conditions and interventions

Conditions

Clinical High Risk for Psychosis (CHR)

Interventions

MT1988 High Dose Drug
MT1988 Low Dose Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 17 Years to 30 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 2, 2026
Primary completion: Aug 31, 2027
Completion: Sep 30, 2027
Last update posted: Apr 1, 2026

2026 – 2027

United States locations

U.S. sites: 15
U.S. states: 9
U.S. cities: 13

Facility	City	State	ZIP	Site status
University of California, Irvine	Irvine	California	92697	Not yet recruiting
University of California	Los Angeles	California	90095	Not yet recruiting
University of California, San Francisco	San Francisco	California	94107	Recruiting
Yale University Conneticut Mental Health Center	New Haven	Connecticut	06519	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02115	Not yet recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Northwell Health	Glen Oaks	New York	11004	Recruiting
Columbia University	New York	New York	10032	Recruiting
Icahan School of Medicine at Mount Sinai	New York	New York	10128	Recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27514	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Prevention Science Institute	Eugene	Oregon	97403	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Temple University	Philadelphia	Pennsylvania	19122	Recruiting
University of Pittsburgh School of Medicine	Pittsburgh	Pennsylvania	15213	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07226895, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 1, 2026 · Synced May 17, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07226895 live on ClinicalTrials.gov.

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