Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Public ClinicalTrials.gov record NCT07227298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL OPEN-LABEL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being done to learn more about a new medicine called PF-08634404 and how it works when used with other cancer medicines in people who have advanced solid tumors. An advanced solid tumor is a type of cancer that has spread beyond its original location and cannot be removed by surgery or cured with standard treatments. To join in the study, participants must: * Be 18 years or older * Participants with advanced non-small cell lung cancer (NSCLC), a type of lung cancer that has spread to other parts of the body The study will look at: * Whether PF-08634404 is safe to use with other cancer medicines. * What side effects may happen. A side effect is anything the medicine does to your body that is not part of treating your disease. * Whether the combination of PF-08634404 and other cancer medicines can help treat solid tumors. The study has different parts, each testing PF-08634404 with a different cancer medicine: * Part A will test PF-08634404 with a medicine called sigvotatug vedotin. * Part B will test PF-08634404 with a medicine called PF-08046054/SGN-PDL1V Participants will receive the study medicines through an intravenous (IV) infusion (injected into the vein) at the study clinic. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.
Study identification
- NCT ID
- NCT07227298
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 162 participants
Conditions and interventions
Conditions
Interventions
- PF-08634404 Biological
- Sigvotatug Vedotin Biological
- PF-08046054/SGN-PDL1V Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 30, 2026 (Actual)
- Primary completion
- Mar 8, 2029 (Estimated)
- Completion
- Aug 23, 2033 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2033
United States locations
- U.S. sites
- 55
- U.S. states
- 9
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group, PA | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group, PA | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | Recruiting |
| Providence Medical Foundation | Fullerton | California | 92835 | Recruiting |
| Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center | Fullerton | California | 92835 | Recruiting |
| Providence St. Jude Medical Center | Fullerton | California | 92835 | Recruiting |
| Scripps Clinic Torrey Pines (Scripps Cancer Center) | La Jolla | California | 92037 | Recruiting |
| Scripps Green Hospital | La Jolla | California | 92037 | Recruiting |
| Scripps Shiley Pavilion | La Jolla | California | 92037 | Recruiting |
| START Los Angeles, LLC | Los Angeles | California | 90025 | Recruiting |
| LACN Century City | Los Angeles | California | 90067 | Recruiting |
| Valkyrie Clinical Trials (Additional Site Pharmacy Storage Suite) | Los Angeles | California | 90067 | Recruiting |
| Valkyrie Clinical Trials (Additional Site Suite) | Los Angeles | California | 90067 | Recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Recruiting |
| Mission Community Hospital (Satellite Site) | Panorama City | California | 91402 | Recruiting |
| Rocky Mountain Cancer Centers,LLP | Aurora | Colorado | 80012 | Recruiting |
| Rocky Mountain Cancer Centers,LLP | Denver | Colorado | 80218 | Recruiting |
| Rocky Mountain Cancer Centers,LLP | Lone Tree | Colorado | 80124 | Recruiting |
| BRCR Medical Center Inc. | Coral Springs | Florida | 33065 | Recruiting |
| Moffitt Cancer Center- Speros | Land O' Lakes | Florida | 34638 | Not yet recruiting |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | Recruiting |
| Orlando Health Ambulatory Care Center | Orlando | Florida | 32806 | Recruiting |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | Recruiting |
| Orlando Health Orlando Regional Medical Center | Orlando | Florida | 32806 | Recruiting |
| Moffitt Cancer Center - SouthShore | Ruskin | Florida | 33570 | Not yet recruiting |
| BRCR Global - Tamarac | Tamarac | Florida | 33321 | Recruiting |
| Moffitt Cancer Center - International Plaza | Tampa | Florida | 33607 | Not yet recruiting |
| Moffitt Cancer Center - McKinley Campus | Tampa | Florida | 33612 | Not yet recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Not yet recruiting |
| Moffitt McKinley Hospital | Tampa | Florida | 33612 | Not yet recruiting |
| Moffitt Cancer Center - Wesley Chapel | Wesley Chapel | Florida | 33544 | Not yet recruiting |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack | New Jersey | 07601 | Recruiting |
| Newman Street Imaging | Hackensack | New Jersey | 07601 | Recruiting |
| John Theurer Cancer Center at JSUMC | Neptune City | New Jersey | 07753 | Recruiting |
| Jack & Sheryl Morris Cancer Center | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| Robert Wood Johnson University Hospital (RWJBH) | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| John Theurer Cancer Center at From Road | Paramus | New Jersey | 07652 | Recruiting |
| Heart Center Glenpointe | Teaneck | New Jersey | 07666 | Recruiting |
| Montefiore Medical Center- Montefiore Medical Park | The Bronx | New York | 10461 | Recruiting |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | Recruiting |
| Dallas Cancer Specialists | Garland | Texas | 75042 | Recruiting |
| Southwest Oncology Associates | Houston | Texas | 77030 | Recruiting |
| Lumi Research | Houston | Texas | 77090 | Recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Recruiting |
| Voyage Clinical | Sugar Land | Texas | 77479 | Recruiting |
| VCU Medical Center Gateway Building | Richmond | Virginia | 23219 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | Recruiting |
| VCU Health Stony Point | Richmond | Virginia | 23235 | Recruiting |
| Massey Cancer Center Clinical & Translational Research Lab | Richmond | Virginia | 23298 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
| VCU Health Community Memorial Hospital | South Hill | Virginia | 23970 | Recruiting |
| VCU Health Tappahannock Hospital | Tappahannock | Virginia | 22560 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07227298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07227298 live on ClinicalTrials.gov.