Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Public ClinicalTrials.gov record NCT07227298. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL OPEN-LABEL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PRELIMINARY EFFICACY OF PF-08634404 IN COMBINATION WITH DIFFERENT ANTICANCER AGENTS IN PARTICIPANTS WITH ADVANCED SOLID TUMORS
Study identification
- NCT ID
- NCT07227298
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 162 participants
Conditions and interventions
Conditions
Interventions
- Combination Agent 1 Biological
- PF-08634404 Biological
- Sigvotatug Vedotin Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 29, 2026
- Primary completion
- Mar 7, 2029
- Completion
- Aug 22, 2033
- Last update posted
- Apr 19, 2026
2026 – 2033
United States locations
- U.S. sites
- 23
- U.S. states
- 7
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group, PA | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group, PA | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | Recruiting |
| Providence Medical Foundation | Fullerton | California | 92835 | Recruiting |
| Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center and Infusion Center | Fullerton | California | 92835 | Recruiting |
| Providence St. Jude Medical Center | Fullerton | California | 92835 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218 | Recruiting |
| BRCR Medical Center Inc. | Coral Springs | Florida | 33065 | Recruiting |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | Recruiting |
| BRCR Global - Tamarac | Tamarac | Florida | 33321 | Recruiting |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | Recruiting |
| Dallas Cancer Specialists | Garland | Texas | 75042 | Not yet recruiting |
| Southwest Oncology Associates | Houston | Texas | 77030 | Not yet recruiting |
| Lumi Research | Houston | Texas | 77090 | Not yet recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Recruiting |
| Voyage Clinical | Sugar Land | Texas | 77479 | Not yet recruiting |
| VCU Medical Center Gateway Building | Richmond | Virginia | 23219 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | Recruiting |
| VCU Health Stony Point | Richmond | Virginia | 23235 | Recruiting |
| Massey Cancer Center Clinical & Translational Research Lab | Richmond | Virginia | 23298 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
| VCU Health Community Memorial Hospital | South Hill | Virginia | 23970 | Recruiting |
| VCU Health Tappahannock Hospital | Tappahannock | Virginia | 22560 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07227298, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07227298 live on ClinicalTrials.gov.