ClinicalTrials.gov record
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
ClinicalTrials.gov ID: NCT07227415
Public ClinicalTrials.gov record NCT07227415. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is testing a new medicine called PF-08634404 and how it works in adults with advanced Renal Cell Carcinoma (RCC)- a type of kidney cancer that is either locally advanced (spread to nearby tissues) or metastatic (spread to other parts of the body). The study will look at the safety of the study medicine, when given alone or with other anticancer medicines, and how this type of cancer responds to them. To join the study, participants must be adults; with locally advanced or metastatic RCC; who have not received treatment for their advanced kidney cancer. Participants will receive study medicine either alone or with other anticancer medicines. The medicine will be given through intravenous (IV) infusions, which means it will be injected directly into a vein. All treatments will take place at clinical study sites, where trained medical staff will take care of participants during and after each visit.
Study identification
- NCT ID
- NCT07227415
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 224 participants
Conditions and interventions
Conditions
- Carcinoma, Renal Cell
- Advanced Renal Cell Carcinoma
- Renal Cancer
- Renal Neoplasm
- Clear Cell Renal Cell Carcinoma
- Metastatic Renal Cell Carcinoma
- Clear-cell Metastatic Renal Cell Carcinoma
- Carcinoma, Renal Cell Metastasis
- Advanced or Metastatic Renal Cell Carcinoma
- Carcinoma, Renal Cell, Advanced
- Metastatic Renal Cell Cancer
- Metastatic Renal Cell Carcinoma ( mRCC)
- Metastatic/Advanced Renal Cell Carcinoma
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 10, 2026 (Actual)
- Primary completion
- Nov 2, 2027 (Estimated)
- Completion
- Nov 1, 2028 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2028
United States locations
- U.S. sites
- 160
- U.S. states
- 19
- U.S. cities
- 104
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Building- Phoenix | Phoenix | Arizona | 85054 | Recruiting |
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | Recruiting |
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | Recruiting |
| UCLA Hematology/Oncology - Alhambra | Alhambra | California | 91801 | Not yet recruiting |
| UCLA Hematology/Oncology - Atascadero | Atascadero | California | 93422 | Not yet recruiting |
| UCLA Hematology/Oncology - Burbank | Burbank | California | 91505 | Not yet recruiting |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | Recruiting |
| City of Hope Investigational Drug Services (IDS) | Duarte | California | 91010 | Recruiting |
| UC San Diego Medical Center - Encinitas | Encinitas | California | 92024 | Recruiting |
| UCLA Hematology/Oncology- Encino | Encino | California | 91436 | Not yet recruiting |
| UCLA Hematology/Oncology- Irvine | Irvine | California | 92604 | Not yet recruiting |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | Recruiting |
| City of Hope Investigational Drug Services (IDS) | Irvine | California | 92618 | Recruiting |
| UC San Diego / Moores Cancer Center | La Jolla | California | 92037 | Recruiting |
| UC San Diego Koman Family Outpatient Pavilion | La Jolla | California | 92037 | Recruiting |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla | California | 92037 | Recruiting |
| UC San Diego Sulpizio Cardiovascular Center | La Jolla | California | 92037 | Recruiting |
| UCLA Hematology/Oncology - Laguna Hills | Laguna Hills | California | 92653 | Not yet recruiting |
| City of Hope | Long Beach | California | 90813 | Recruiting |
| Investigational Drug Services, Bowyer Pharmacy | Los Angeles | California | 90095 | Not yet recruiting |
| Ronald Reagan UCLA Medical Center, Drug Information Center | Los Angeles | California | 90095 | Not yet recruiting |
| UCLA Hematology/Oncology | Los Angeles | California | 90095 | Not yet recruiting |
| UCLA Hematology/Oncology - Marina del Rey | Marina del Rey | California | 90292 | Not yet recruiting |
| UCLA Hematology/Oncology - Pasadena | Pasadena | California | 91105 | Not yet recruiting |
| UCLA Hematology/Oncology - Porter Ranch | Porter Ranch | California | 91326 | Not yet recruiting |
| UC San Diego Medical Center - Bankers Hill | San Diego | California | 92101 | Recruiting |
| UC San Diego McGrath Outpatient Pavilion - Hillcrest | San Diego | California | 92103 | Recruiting |
| UC San Diego Medical Center - Hillcrest | San Diego | California | 92103 | Recruiting |
| UC San Diego Medical Center - Rancho Bernardo | San Diego | California | 92127 | Recruiting |
| UCLA Hematology/Oncology - San Luis Obispo | San Luis Obispo | California | 93401 | Not yet recruiting |
| UCLA Hematology/Oncology- Santa Barbara | Santa Barbara | California | 93101 | Not yet recruiting |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | Not yet recruiting |
| UCLA Hematology/Oncology- Torrance | Torrance | California | 90505 | Not yet recruiting |
| City of Hope UPLAND | Upland | California | 91786 | Recruiting |
| UCLA Hematology/Oncology - Santa Clarita | Valencia | California | 91355 | Not yet recruiting |
| UCLA Hematology/Oncology- Ventura | Ventura | California | 93003 | Not yet recruiting |
| UC San Diego Medical Center - Vista | Vista | California | 92081 | Recruiting |
| UCLA Hematology/Oncology- Westlake | Westlake Village | California | 91361 | Not yet recruiting |
| Rocky Mountain Cancer Centers,LLP | Aurora | Colorado | 80012 | Recruiting |
| Clinical and Translational Research Center(CTRC) | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP) | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital-Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | Recruiting |
| UCHealth Cherry Creek Medical Center | Denver | Colorado | 80206 | Recruiting |
| Rocky Mountain Cancer Centers,LLP | Denver | Colorado | 80218 | Recruiting |
| Highlands Ranch Hospital | Highlands Ranch | Colorado | 80129 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Lakewood | Colorado | 80228 | Recruiting |
| Rocky Mountain Cancer Centers,LLP | Lone Tree | Colorado | 80124 | Recruiting |
| UC Health Lone Tree Medical Center | Lone Tree | Colorado | 80124 | Recruiting |
| Mayo Clinic Pharmacy | Jacksonville | Florida | 32224 | Recruiting |
| Orlando Health Cancer Institute | Lake Mary | Florida | 32746 | Recruiting |
| Orlando Health Ambulatory Care Center | Orlando | Florida | 32806 | Recruiting |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | Recruiting |
| Orlando Health Orlando Regional Medical Center | Orlando | Florida | 32806 | Recruiting |
| Tennessee Oncology, PLLC- Ringgold | Ringgold | Georgia | 30736 | Recruiting |
| Memorial Hospital | Shiloh | Illinois | 62269 | Recruiting |
| Siteman Cancer Center - Shiloh | Shiloh | Illinois | 62269 | Recruiting |
| City Of Hope - Chicago | Zion | Illinois | 60099 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Dana-Farber Cancer Institute - Chestnut Hill | Newton | Massachusetts | 02467 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Burnsville | Minnesota | 55337 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Chaska | Minnesota | 55318 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | 55433 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Edina | Minnesota | 55435 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Maple Grove | Minnesota | 55369 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Maplewood | Minnesota | 55109 | Recruiting |
| Mayo Clinic Hospital, Methodist Campus, Research Pharmacy | Rochester | Minnesota | 55902 | Recruiting |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Rochester | Minnesota | 55905 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Woodbury | Minnesota | 55125 | Recruiting |
| Siteman Cancer Center - St. Peters | City of Saint Peters | Missouri | 63376 | Recruiting |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | Recruiting |
| Siteman Cancer Center - North County | Florissant | Missouri | 63031 | Recruiting |
| Siteman Cancer Center | St Louis | Missouri | 63108 | Recruiting |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | Recruiting |
| Washington University School of Medicine - Siteman Cancer Center | St Louis | Missouri | 63110 | Recruiting |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | Recruiting |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| MSK Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| MSK Bergen | Montvale | New Jersey | 07645 | Recruiting |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | Recruiting |
| New York Oncology Hematology - Clifton Park Cancer Center | Clifton Park | New York | 12065 | Recruiting |
| MSK Commack | Commack | New York | 11725 | Recruiting |
| MSK Westchester | Harrison | New York | 10604 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy | Long Island City | New York | 11101 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Evelyn H. Lauder Breast and Imaging Center (BAIC) | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Main Campus | New York | New York | 10065 | Recruiting |
| Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| MSK Nassau | Uniondale | New York | 11553 | Recruiting |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | Recruiting |
| Grand Strand Medical Center | Myrtle Beach | South Carolina | 295724607 | Recruiting |
| Carolina Urologic Research Center, LLC | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Parkway Surgery Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Tennessee Oncology, PLLC- Chattanooga Downtown | Chattanooga | Tennessee | 37403 | Recruiting |
| Tennessee Oncology, PLLC - Chattanooga Med Park II | Chattanooga | Tennessee | 37404 | Recruiting |
| Tennessee Oncology, PLLC - Chattanooga Memorial | Chattanooga | Tennessee | 37404 | Recruiting |
| Tennessee Oncology, PLLC - Investigational Drug Services/Supply Storage | Chattanooga | Tennessee | 37404 | Recruiting |
| Tennessee Oncology, PLLC- Chattanooga East | Chattanooga | Tennessee | 37421 | Recruiting |
| Tennessee Oncology, PLLC- Cookeville | Cookeville | Tennessee | 38501 | Recruiting |
| Tennessee Oncology, PLLC-Dickson | Dickson | Tennessee | 37055 | Recruiting |
| Tennessee Oncology, PLLC- Franklin Proton Center | Franklin | Tennessee | 37067 | Recruiting |
| Tennessee Oncology, PLLC-Franklin | Franklin | Tennessee | 37067 | Recruiting |
| Tennessee Oncology, PLLC-Gallatin | Gallatin | Tennessee | 37066 | Recruiting |
| Tennessee Oncology, PLLC-Hendersonville | Hendersonville | Tennessee | 37075 | Recruiting |
| Tennessee Oncology, PLLC-Lebanon | Lebanon | Tennessee | 37090 | Recruiting |
| Tennessee Oncology, PLLC-Mount Juliet | Mount Juliet | Tennessee | 37122 | Recruiting |
| Tennessee Oncology, PLLC-Murfreesboro | Murfreesboro | Tennessee | 37129 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC- Elliston Place Plaza | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC-Elliston Place Plaza Medical Oncology &Hematology | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC-Investigational Drug Services | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology, PLLC- Saint Thomas West | Nashville | Tennessee | 37205 | Recruiting |
| Tennessee Oncology, PLLC- Skyline | Nashville | Tennessee | 37207 | Recruiting |
| Tennessee Oncology, PLLC- Southern Hills | Nashville | Tennessee | 37211 | Recruiting |
| Henry-Joyce Cancer Clinic | Nashville | Tennessee | 37232 | Recruiting |
| Tennessee Oncology, PLLC- Shelbyville | Shelbyville | Tennessee | 37160 | Recruiting |
| Tennessee Oncology, PLLC- Smyrna | Smyrna | Tennessee | 37167 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78705 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78731 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78745 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78758 | Recruiting |
| Texas Oncology - Gulf Coast | Beaumont | Texas | 77702 | Recruiting |
| The University of Texas, MD Anderson Cancer Center - Conroe | Conroe | Texas | 77384 | Not yet recruiting |
| University of Texas Southwestern Medical Center - Simmons Cancer Center | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Redbird | Dallas | Texas | 75237 | Recruiting |
| University of Texas Southwestern Medical Center-Zale Lipshy University Hospital | Dallas | Texas | 75390 | Recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| Texas Oncology - Central South | Harlingen | Texas | 78550 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77024 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Not yet recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77054 | Recruiting |
| The University of Texas, MD Anderson Cancer Center - West Houston | Houston | Texas | 77079 | Not yet recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Recruiting |
| US Oncology Investigational Products Center | Irving | Texas | 75063 | Recruiting |
| The University of Texas, MD Anderson Cancer Center - League City | League City | Texas | 77573 | Not yet recruiting |
| Texas Oncology - Central South | McAllen | Texas | 78503 | Recruiting |
| Texas Oncology - Gulf Coast | Pearland | Texas | 77584 | Recruiting |
| University of Texas Southwestern Simmons Cancer Center - Richardson/Plano | Richardson | Texas | 75080 | Recruiting |
| The University of Texas, MD Anderson Cancer Center - Sugar Land | Sugar Land | Texas | 77478 | Not yet recruiting |
| Texas Oncology - Gulf Coast | Sugar Land | Texas | 77479 | Recruiting |
| Texas Oncology - Gulf Coast | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology - Central South | Waco | Texas | 76712 | Recruiting |
| Texas Oncology - Gulf Coast | Webster | Texas | 77598 | Recruiting |
| Texas Oncology - Central South | Weslaco | Texas | 78596 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | Recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| University Of Washington Medical Center | Seattle | Washington | 98195 | Recruiting |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Hudson | Wisconsin | 54016 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07227415, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07227415 live on ClinicalTrials.gov.