ClinicalTrials.gov record
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
ClinicalTrials.gov ID: NCT07227415
Public ClinicalTrials.gov record NCT07227415. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 7:56 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL PHASE 1B/2 STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PF-08634404 MONOTHERAPY AND IN COMBINATION WITH OTHER ANTICANCER AGENTS IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA
Study identification
- NCT ID
- NCT07227415
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 224 participants
Conditions and interventions
Conditions
- Advanced Renal Cell Carcinoma
- Advanced or Metastatic Renal Cell Carcinoma
- Carcinoma, Renal Cell
- Carcinoma, Renal Cell Metastasis
- Carcinoma, Renal Cell, Advanced
- Clear Cell Renal Cell Carcinoma
- Clear-cell Metastatic Renal Cell Carcinoma
- Metastatic Renal Cell Cancer
- Metastatic Renal Cell Carcinoma
- Metastatic Renal Cell Carcinoma ( mRCC)
- Metastatic/Advanced Renal Cell Carcinoma
- Renal Cancer
- Renal Neoplasm
Interventions
- Combination 1 Drug
- Combination 2 Drug
- PF-08634404 Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 11, 2026
- Primary completion
- Nov 1, 2027
- Completion
- Oct 31, 2028
- Last update posted
- Apr 19, 2026
2026 – 2028
United States locations
- U.S. sites
- 44
- U.S. states
- 11
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group | Fayetteville | Arkansas | 72703 | Recruiting |
| Highlands Oncology Group | Rogers | Arkansas | 72758 | Recruiting |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | Recruiting |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | Recruiting |
| City of Hope Investigational Drug Services (IDS) | Duarte | California | 91010 | Recruiting |
| City of Hope Investigational Drug Services (IDS) | Irvine | California | 92618 | Recruiting |
| City of Hope | Irvine | California | 92618 | Recruiting |
| City of Hope | Long Beach | California | 90813 | Recruiting |
| City of Hope UPLAND | Upland | California | 91786 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218 | Recruiting |
| City Of Hope - Chicago | Zion | Illinois | 60099 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Burnsville | Minnesota | 55337 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Chaska | Minnesota | 55318 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | 55433 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Edina | Minnesota | 55435 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Maple Grove | Minnesota | 55369 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Maplewood | Minnesota | 55109 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Woodbury | Minnesota | 55125 | Recruiting |
| New York Oncology Hematology, P.C. | Albany | New York | 12206 | Not yet recruiting |
| New York Oncology Hematology - Clifton Park Cancer Center | Clifton Park | New York | 12065 | Not yet recruiting |
| Grand Strand Medical Center | Myrtle Beach | South Carolina | 295724607 | Recruiting |
| Carolina Urologic Research Center, LLC | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Parkway Surgery Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78731 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78758 | Recruiting |
| Texas Oncology - Gulf Coast | Beaumont | Texas | 77702 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77024 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77054 | Recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Recruiting |
| US Oncology Investigational Products Center | Irving | Texas | 75063 | Recruiting |
| Texas Oncology - Central South | McAllen | Texas | 78503 | Recruiting |
| Texas Oncology - Gulf Coast | Pearland | Texas | 77584 | Recruiting |
| Texas Oncology - Gulf Coast | Sugar Land | Texas | 77479 | Recruiting |
| Texas Oncology - Gulf Coast | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology - Gulf Coast | Webster | Texas | 77598 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | Recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | Recruiting |
| Minnesota Oncology Hematology, P.A. | Hudson | Wisconsin | 54016 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07227415, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07227415 live on ClinicalTrials.gov.