ClinicalTrials.gov record
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
ClinicalTrials.gov ID: NCT07228832
Public ClinicalTrials.gov record NCT07228832. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)
Study identification
- NCT ID
- NCT07228832
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 17, 2025
- Primary completion
- May 30, 2028
- Completion
- Nov 29, 2029
- Last update posted
- Sep 1, 2026
2025 – 2029
United States locations
- U.S. sites
- 102
- U.S. states
- 35
- U.S. cities
- 88
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Study Site | Mobile | Alabama | 36604 | Recruiting |
| Clinical Study Site | Tuscaloosa | Alabama | 35487 | Recruiting |
| Clinical Study Site | Goodyear | Arizona | 85338 | Recruiting |
| Clinical Study Site | Beverly Hills | California | 90211 | Recruiting |
| Clinical Study Site | Beverly Hills | California | 90212 | Recruiting |
| Clinical Study Site | Cerritos | California | 90703 | Recruiting |
| Clinical Study Site | Corona | California | 92882 | Recruiting |
| Clinical Study Site | Duarte | California | 91010 | Recruiting |
| Clinical Study Site | Fountain Valley | California | 92708 | Recruiting |
| Clinical Study Site | Huntington Beach | California | 92648 | Recruiting |
| Clinical Study Site | Irvine | California | 92612 | Recruiting |
| Clinical Study Site | Irvine | California | 92618 | Recruiting |
| Clinical Study Site | Los Angeles | California | 90027 | Recruiting |
| Clinical Study Site | Los Angeles | California | 90067 | Recruiting |
| Clinical Study Site | Los Angeles | California | 90404 | Recruiting |
| Clinical Study Site | Murrieta | California | 92562 | Recruiting |
| Clinical Study Site | Oakland | California | 94611 | Recruiting |
| Clinical Study Site | Orange | California | 92868 | Recruiting |
| Clinical Study Site | Pasadena | California | 91030 | Recruiting |
| Clinical Study Site | Roseville | California | 95661 | Recruiting |
| Clinical Study Site | San Francisco | California | 94115 | Recruiting |
| Clinical Study Site | Santa Clara | California | 94115 | Recruiting |
| Clinical Study Site | Stanford | California | 94305 | Recruiting |
| Clinical Study Site | Torrance | California | 90503 | Recruiting |
| Clinical Study Site | Upland | California | 91786 | Recruiting |
| Clinical Study Site | Vallejo | California | 94589 | Recruiting |
| Clinical Study Site | West Hollywood | California | 90048 | Recruiting |
| Clinical Study Site | Hartford | Connecticut | 06106 | Recruiting |
| Clinical Study Site | New Haven | Connecticut | 06520-8028 | Recruiting |
| Clinical Study Site | Norwich | Connecticut | 06360 | Recruiting |
| Clinical Study Site | Newark | Delaware | 19713 | Recruiting |
| Clinical Study Site | Hialeah | Florida | 33013 | Recruiting |
| Clinical Study Site | Miami | Florida | 33176 | Recruiting |
| Clinical Study Site | Miami Beach | Florida | 33140 | Recruiting |
| Clinical Study Site | Ocala | Florida | 34474 | Recruiting |
| Clinical Study Site | Orlando | Florida | 32804 | Recruiting |
| Clinical Study Site | Orlando | Florida | 32806 | Recruiting |
| Clinical Study Site | Plantation | Florida | 33322 | Recruiting |
| Clinical Study Site | Port Saint Lucie | Florida | 34952 | Recruiting |
| Clinical Study Site | St. Petersburg | Florida | 33705 | Recruiting |
| Clinical Study Site | Tamarac | Florida | 33321 | Recruiting |
| Clinical Study Site | Atlanta | Georgia | 30303 | Recruiting |
| Clinical Study Site | Atlanta | Georgia | 30322 | Recruiting |
| Clinical Study Site | Newnan | Georgia | 30265 | Recruiting |
| Clinical Study Site | Chicago | Illinois | 60611 | Recruiting |
| Clinical Study Site | Elmhurst | Illinois | 60540 | Recruiting |
| Clinical Study Site | O'Fallon | Illinois | 62269 | Recruiting |
| Clinical Study Site | Fort Wayne | Indiana | 46804 | Recruiting |
| Clinical Study Site | Indianapolis | Indiana | 46202 | Recruiting |
| Clinical Study Site | Westwood | Kansas | 66205 | Recruiting |
| Clinical Study Site | Edgewood | Kentucky | 41017 | Recruiting |
| Clinical Study Site | New Orleans | Louisiana | 70121 | Recruiting |
| Clinical Study Site | Baltimore | Maryland | 21201 | Recruiting |
| Clinical Study Site | Detroit | Michigan | 48201 | Recruiting |
| Clinical Study Site | Saint Louis Park | Minnesota | 55426 | Recruiting |
| Clinical Study Site | Springfield | Missouri | 65804 | Recruiting |
| Clinical Study Site | Billings | Montana | 59102 | Recruiting |
| Clinical Study Site | Lincoln | Nebraska | 68506 | Recruiting |
| Clinical Study Site | Lebanon | New Hampshire | 03766 | Recruiting |
| Clinical Study Site | New Brunswick | New Jersey | 08901 | Recruiting |
| Clinical Study Site | Mineola | New York | 11501 | Recruiting |
| Clinical Study Site | New York | New York | 10016 | Recruiting |
| Clinical Study Site | Rochester | New York | 14642 | Recruiting |
| Clinical Study Site | Syracuse | New York | 13210 | Recruiting |
| Clinical Study Site | The Bronx | New York | 10461 | Recruiting |
| Clinical Study Site | White Plains | New York | 10601-5000 | Recruiting |
| Clinical Study Site | Pinehurst | North Carolina | 28374 | Recruiting |
| Clinical Study Site | Akron | Ohio | 44032 | Recruiting |
| Clinical Study Site | Canton | Ohio | 44703 | Recruiting |
| Clinical Study Site | Cincinnati | Ohio | 45219 | Recruiting |
| Clinical Study Site | Cincinnati | Ohio | 45220 | Recruiting |
| Clinical Study Site | Cleveland | Ohio | 44111 | Recruiting |
| Clinical Study Site | Cleveland | Ohio | 44195 | Recruiting |
| Clinical Study Site | Mayfield Heights | Ohio | 44124 | Recruiting |
| Clinical Study Site | Oklahoma City | Oklahoma | 73120 | Recruiting |
| Clinical Study Site | Lebanon | Pennsylvania | 17042 | Recruiting |
| Clinical Study Site | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Clinical Study Site | Philadelphia | Pennsylvania | 19111 | Recruiting |
| Clinical Study Site | Philadelphia | Pennsylvania | 19140 | Recruiting |
| Clinical Study Site | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| Clinical Study Site | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Clinical Study Site | Sellersville | Pennsylvania | 18960 | Recruiting |
| Clinical Study Site | Providence | Rhode Island | 02903 | Recruiting |
| Clinical Study Site | Greenville | South Carolina | 29605 | Recruiting |
| Clinical Study Site | Spartanburg | South Carolina | 29303 | Recruiting |
| Clinical Study Site | Germantown | Tennessee | 38138 | Recruiting |
| Clinical Study Site | Hermitage | Tennessee | 37129 | Recruiting |
| Clinical Study Site | Dallas | Texas | 75235 | Recruiting |
| Clinical Study Site | Dallas | Texas | 75390 | Recruiting |
| Clinical Study Site | Fort Worth | Texas | 76104 | Recruiting |
| Clinical Study Site | Houston | Texas | 77026 | Recruiting |
| Clinical Study Site | Houston | Texas | 77030 | Recruiting |
| Clinical Study Site | Tyler | Texas | 75701 | Recruiting |
| Clinical Study Site | Salt Lake City | Utah | 84106 | Recruiting |
| Clinical Study Site | Salt Lake City | Utah | 84112 | Recruiting |
| Clinical Study Site | Burlington | Vermont | 05401 | Recruiting |
| Clinical Study Site | Charlottesville | Virginia | 22908 | Recruiting |
| Clinical Study Site | Fairfax | Virginia | 22031 | Recruiting |
| Clinical Study Site | Spokane | Washington | 99208 | Recruiting |
| Clinical Study Site | Tacoma | Washington | 98405 | Recruiting |
| Clinical Study Site | Charleston | West Virginia | 25304 | Recruiting |
| Clinical Study Site | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 83 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07228832, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 1, 2026 · Synced Sep 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07228832 live on ClinicalTrials.gov.