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Recruiting Phase 3 Interventional

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

ClinicalTrials.gov ID: NCT07252232

Public ClinicalTrials.gov record NCT07252232. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 20, 2026, 4:49 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and/or Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Study identification

NCT ID
NCT07252232
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Revolution Medicines, Inc.
Industry
Enrollment
500 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 15, 2025 (Actual)
Primary completion
May 10, 2029 (Estimated)
Completion
Jul 10, 2030 (Estimated)
Last update posted
Sep 23, 2026

2025 – 2030

United States locations

U.S. sites
43
U.S. states
25
U.S. cities
36
Facility City State ZIP Site status
Mayo Clinic Phoenix Arizona 85054 Recruiting
HonorHealth Research Institute Scottsdale Arizona 85258 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92037 Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
University of California, Los Angeles Los Angeles California 90404 Recruiting
Stanford Cancer Institute Palo Alto California 94304 Recruiting
University of California, Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
University of California, San Francisco San Francisco California 94143 Recruiting
Rocky Mountain Cancer Centers, LLP Lakewood Colorado 80228 Recruiting
Hartford Healthcare Hartford Connecticut 06103 Recruiting
Mayo Clinic Jacksonville Florida 32224 Recruiting
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center Miami Florida 33136 Recruiting
Florida Cancer Specialists St. Petersburg Florida 33701 Recruiting
Piedmont Physicians Medical Oncology Atlanta Atlanta Georgia 30318 Recruiting
Winship Cancer Institute, Emory University Atlanta Georgia 30322 Recruiting
Community Health Network Indianapolis Indiana 46250 Recruiting
University of Kansas Medical Center Research Institute, Inc. Lawrence Kansas 66045 Recruiting
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital Baltimore Maryland 21287 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Dana Farber Cancer Institute (DFCI) Boston Massachusetts 02215 Recruiting
Mayo Clinic Cancer Center Rochester Minnesota 55905 Recruiting
Saint Luke's Cancer Institute Kansas City Missouri 64111 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Comprehensive Cancer Centers of Nevada Las Vegas Nevada 89169 Recruiting
Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center New York New York 10016 Recruiting
Icahn School of Medicine at Mount Sinai New York New York 10029 Recruiting
Columbia University Medical Center New York New York 10032 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
University of Rochester Medical Center Rochester New York 14642 Recruiting
Duke Cancer Center Durham North Carolina 27710 Recruiting
Taylor Cancer Research Center Maumee Ohio 43537 Recruiting
University of Pennsylvania, Abramson Cancer Center Philadelphia Pennsylvania 19104 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
Avera Cancer Institute Sioux Falls South Dakota 57105 Recruiting
SCRI Oncology Partners Nashville Tennessee 37203 Recruiting
Texas Oncology - DFW Dallas Texas 75246 Recruiting
University of Texas, Southwestern Medical Center Dallas Texas 75390 Recruiting
University of Texas MD Anderson Cancer Center Houston Texas 77030 Not yet recruiting
Texas Oncology - Northeast Texas Longview Texas 75601 Recruiting
University of Utah, Huntsman Cancer Institute Salt Lake City Utah 94112 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting
Fred Hutchison Cancer Center Seattle Washington 98109 Recruiting
Froedtert Hospital and the Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 35 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07252232, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 23, 2026 · Synced Oct 20, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07252232 live on ClinicalTrials.gov.

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