Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

ClinicalTrials.gov ID: NCT07252232

Public ClinicalTrials.gov record NCT07252232. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 3:27 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and/or Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Study identification

NCT ID: NCT07252232
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Revolution Medicines, Inc.; Industry
Enrollment: 500 participants

Conditions and interventions

Conditions

Interventions

daraxonrasib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 14, 2025
Primary completion: May 9, 2029
Completion: Jul 9, 2030
Last update posted: Aug 24, 2026

2025 – 2030

United States locations

U.S. sites: 35
U.S. states: 23
U.S. cities: 31

Facility	City	State	ZIP	Site status
Mayo Clinic	Phoenix	Arizona	85054	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92037	Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
University of California, Los Angeles	Los Angeles	California	90404	Recruiting
Stanford Cancer Institute	Palo Alto	California	94304	Recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Rocky Mountain Cancer Centers, LLP	Lakewood	Colorado	80228	Recruiting
Hartford Healthcare	Hartford	Connecticut	06103	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center	Miami	Florida	33136	Recruiting
Florida Cancer Specialists	St. Petersburg	Florida	33701	Recruiting
Winship Cancer Institute, Emory University	Atlanta	Georgia	30322	Recruiting
Community Health Network	Indianapolis	Indiana	46250	Recruiting
University of Kansas Medical Center Research Institute, Inc.	Lawrence	Kansas	66045	Recruiting
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital	Baltimore	Maryland	21287	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Dana Farber Cancer Institute (DFCI)	Boston	Massachusetts	02215	Recruiting
Mayo Clinic Cancer Center	Rochester	Minnesota	55905	Recruiting
Saint Luke's Cancer Institute	Kansas City	Missouri	64111	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169	Recruiting
Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center	New York	New York	10016	Recruiting
Columbia University Medical Center	New York	New York	10032	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester Medical Center	Rochester	New York	14642	Recruiting
Duke Cancer Center	Durham	North Carolina	27710	Recruiting
Taylor Cancer Research Center	Maumee	Ohio	43537	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
SCRI Oncology Partners	Nashville	Tennessee	37203	Recruiting
Texas Oncology - DFW	Dallas	Texas	75246	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Not yet recruiting
Texas Oncology - Northeast Texas	Longview	Texas	75601	Recruiting
University of Utah, Huntsman Cancer Institute	Salt Lake City	Utah	94112	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting
Froedtert Hospital and the Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07252232, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 24, 2026 · Synced Sep 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07252232 live on ClinicalTrials.gov.

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