A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

ClinicalTrials.gov ID: NCT07253285

Public ClinicalTrials.gov record NCT07253285. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Sep 2, 2026, 4:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Efficacy, Safety and Pharmacokinetics of Cagrilintide s.c. 2.4 mg as Monotherapy and in Combination With Semaglutide s.c. 2.4 mg (CagriSema) Once Weekly for Weight Management in Chidren and Adolescents With Overweight or Obesity

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to adolescents and adults) or placebo (a placebo looks like the treatment being tested, but doesn't have any active ingredients in it). Which treatment participants will get is decided by chance. Participants who get semaglutide in the main study will not take part in the extension study. If participants take part in the extension study, they will get either CagriSema or cagrilintide in this part of the study. Like all drugs, the study drugs may have side effects. The total time participants will be in the main study is about 1 year and 6 months. If participants take part in the extension study, the total time is about 4 years and 10 months.

Study identification

NCT ID: NCT07253285
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 460 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 8 Years to 18 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 7, 2026
Primary completion: Mar 19, 2030
Completion: Sep 19, 2033
Last update posted: Aug 30, 2026

2026 – 2033

United States locations

U.S. sites: 34
U.S. states: 19
U.S. cities: 32

Facility	City	State	ZIP	Site status
Neighborhood Healthcare	Escondido	California	92025	Recruiting
Encore Medical Research LLC	Hollywood	Florida	33024	Recruiting
Jacksonville Ctr for Clin Res	Jacksonville	Florida	32216	Recruiting
Encore Medical Research of Weston	Weston	Florida	33331	Recruiting
Children's Healthcare Atlanta	Atlanta	Georgia	30329	Recruiting
Columbus Research Foundation	Columbus	Georgia	31904	Recruiting
Accel Research Sites-NeuroStudies	Decatur	Georgia	30030	Recruiting
Eastside Bariatric and Gen Surg	Snellville	Georgia	30078	Recruiting
Solaris Clinical Research	Meridian	Idaho	83646	Recruiting
IU Health - Riley Physicians Endo-Diab	Indianapolis	Indiana	46202	Recruiting
Cotton O'Neil Clinical Research Center	Topeka	Kansas	66606	Recruiting
Pennington Biomed Res Ctr	Baton Rouge	Louisiana	70808-4124	Recruiting
Barry J. Reiner, MD LLC	Baltimore	Maryland	21229	Recruiting
University of Minnesota	Minneapolis	Minnesota	55455	Recruiting
Synexus Clinical Research US-MN	Richfield	Minnesota	55423	Recruiting
UBMD Physicians Group - Pediatrics - Conventus	Buffalo	New York	14203	Not yet recruiting
SUNY Upstate Medical Univ - Syracuse	Syracuse	New York	13210	Not yet recruiting
Advantage Clinical Trials	The Bronx	New York	10467	Not yet recruiting
Valley Weight Loss Clinic	Fargo	North Dakota	58104	Recruiting
Centricity Research - Ohio	Columbus	Ohio	43213	Recruiting
PriMed Clinical Research	Dayton	Ohio	45429	Recruiting
Children's Physicians OU	Oklahoma City	Oklahoma	73104	Not yet recruiting
UPMC Child Hosp-Pittsburgh	Pittsburgh	Pennsylvania	15224	Not yet recruiting
Prisma Health-Ped Endo	Greenville	South Carolina	29615	Not yet recruiting
Coastal Carolina Research Ctr	North Charleston	South Carolina	29405	Recruiting
Monument Health Clinical Rsrch	Rapid City	South Dakota	57701	Not yet recruiting
LifeDoc Health	Memphis	Tennessee	38115	Recruiting
DM Clinical	Houston	Texas	77065	Recruiting
DM Clinical	San Antonio	Texas	78207	Not yet recruiting
The Texas Liver Institute	San Antonio	Texas	78215	Recruiting
Pinnacle Clinical Research	San Antonio	Texas	78222	Recruiting
Consano Clin Res-Shavano Park	Shavano Park	Texas	78231	Recruiting
Texas Valley Clinical Research	Weslaco	Texas	78596	Recruiting
AMR Clinical	Layton	Utah	84041	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 87 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07253285, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 30, 2026 · Synced Sep 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07253285 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →