Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

ClinicalTrials.gov ID: NCT07265947

Public ClinicalTrials.gov record NCT07265947. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 8:16 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2A/B, Multi-center, Open-Label Study Evaluating the Efficacy and Safety of Dabogratinib (TYRA-300) in Participants With Low Grade Upper Tract Urothelial Carcinoma (SURF303)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A Phase 2A/B study of Dabogratinib (TYRA-300) in Low Grade Upper Tract Urothelial Carcinoma

Study identification

NCT ID: NCT07265947
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Tyra Biosciences, Inc; Industry
Enrollment: 230 participants

Conditions and interventions

Conditions

Low Grade Upper Tract Urothelial Carcinoma

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 21, 2025
Primary completion: Sep 30, 2030
Completion: Oct 31, 2030
Last update posted: Aug 20, 2026

2025 – 2030

United States locations

U.S. sites: 17
U.S. states: 12
U.S. cities: 17

Facility	City	State	ZIP	Site status
Moffitt Cancer Center	Tampa	Florida	33612-9416	Recruiting
The Winship Cancer Institute of Emory University	Atlanta	Georgia	30322-1013	Recruiting
Duly Health and Care Chicago	Lisle	Illinois	60532	Recruiting
Urology of Indiana, LLC	Greenwood	Indiana	46143	Recruiting
First Urology	Jeffersonville	Indiana	47130	Recruiting
Greater Boston Urology - Plymouth Care Center	Plymouth	Massachusetts	02360	Recruiting
Urology of St. Louis	St Louis	Missouri	63141	Recruiting
Summit Health - Washington Township	Sewell	New Jersey	08080-2359	Recruiting
Albany Medical College	Albany	New York	12208-3412	Recruiting
Associated Medical Professionals of NY, PLLC	Syracuse	New York	13210	Recruiting
Cleveland Clinic	Cleveland	Ohio	44111	Recruiting
Central Ohio Urology Group	Gahanna	Ohio	43230	Recruiting
Penn Medicine Radnor	Radnor	Pennsylvania	19087	Recruiting
Urology Associates, P C	Nashville	Tennessee	37209-4035	Recruiting
Urology Austin - Apex Cancer Care - Austin	Austin	Texas	78705-2009	Recruiting
The University of Texas Southwestern Medical Center	Dallas	Texas	75235	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07265947, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 20, 2026 · Synced Sep 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07265947 live on ClinicalTrials.gov.

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