A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia

ClinicalTrials.gov ID: NCT07269210

Public ClinicalTrials.gov record NCT07269210. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 30, 2026, 1:36 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3561774 (Solbinsiran) in Adults With Severe Hypertriglyceridemia

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the safety and efficacy of solbinsiran in lowering triglycerides and other lipid measures compared to placebo in participants with severe hypertriglyceridemia. Participants will receive two subcutaneous injections.

Study identification

NCT ID: NCT07269210
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 60 participants

Conditions and interventions

Conditions

Severe Hypertriglyceridemia

Interventions

Solbinsiran Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 8, 2025 (Actual)
Primary completion: Mar 2027 (Estimated)
Completion: Aug 2027 (Estimated)
Last update posted: Oct 8, 2026

2025 – 2027

United States locations

U.S. sites: 29
U.S. states: 15
U.S. cities: 27

Facility	City	State	ZIP	Site status
Onyx Clinical Research	Phoenix	Arizona	85014	Completed
Synexus Clinical Research US, Inc./Orange Grove Family Practice	Tucson	Arizona	85741	Completed
National Heart Institute	Beverly Hills	California	90211	Completed
Ark Clinical Research	Long Beach	California	90815	Active, not recruiting
Catalina Research Institute, LLC	Montclair	California	91763	Active, not recruiting
Valley Clinical Trials, LLC dba Flourish Research	Northridge	California	91325	Active, not recruiting
CMR of Greater New Haven, LLC	Hamden	Connecticut	06517	Completed
Northeast Research Institute - Downtown Office	Jacksonville	Florida	32204	Active, not recruiting
Novera Clinical Research	Miami	Florida	33135	Active, not recruiting
Inpatient Research Clinic	Miami Lakes	Florida	33014	Active, not recruiting
Clinical Site Partners, LLC dba Flourish Research	Winter Park	Florida	32789	Completed
Great Lakes Clinical Trials - Ravenswood	Chicago	Illinois	60640	Active, not recruiting
Investigators Research Group	Brownsburg	Indiana	46112	Active, not recruiting
Saint Elizabeth Healthcare - Saint Elizabeth Covington Hospital	Covington	Kentucky	41011	Active, not recruiting
Flourish Research - Bowie	Bowie	Maryland	20715	Completed
University of Massachusetts Chan Medical School	Worcester	Massachusetts	01655	Completed
AB Clinical Trials	Las Vegas	Nevada	89119	Completed
Clinical Research of Philadelphia	Pennington	New Jersey	08534	Active, not recruiting
Weill Cornell Medical College	New York	New York	10021	Completed
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Active, not recruiting
Cardiovascular Specialists of Willowbrook	Houston	Texas	77070	Active, not recruiting
Southern Endocrinology Associates	Mesquite	Texas	75149	Active, not recruiting
American Research Corporation at Texas Liver Institute	San Antonio	Texas	78215	Completed
Endeavor Clinical Trials	San Antonio	Texas	78240	Completed
Stroobants Cardiovascular Center	Lynchburg	Virginia	24501	Completed
TPMG (Tidewater Physicians Multispecialty Group) Clinical Research	Newport News	Virginia	23606	Active, not recruiting
Carilion Clinic	Roanoke	Virginia	24014	Active, not recruiting
Eastside Research Associates	Redmond	Washington	98052	Active, not recruiting
UW Medicine Diabetes Institute	Seattle	Washington	98109	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07269210, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 8, 2026 · Synced Oct 30, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT07269210 live on ClinicalTrials.gov.

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