Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease

ClinicalTrials.gov ID: NCT07271186

Public ClinicalTrials.gov record NCT07271186. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 11:04 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With an ANGPTL3 Antibody in Participants With Diabetic Kidney Disease

Study identification

NCT ID: NCT07271186
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Regeneron Pharmaceuticals; Industry
Enrollment: 270 participants

Conditions and interventions

Conditions

Diabetic Kidney Disease (DKD)

Interventions

ALN-ANG3 Drug
ALN-ANG3 placebo Drug
Evinacumab Drug
Evinacumab placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 80 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 8, 2026
Primary completion: Sep 23, 2027
Completion: Apr 6, 2028
Last update posted: Apr 27, 2026

2026 – 2028

United States locations

U.S. sites: 47
U.S. states: 14
U.S. cities: 42

Facility	City	State	ZIP	Site status
Apogee Clinical Research, LLC	Huntsville	Alabama	35801	Recruiting
Applied Research Center of Arkansas	Little Rock	Arkansas	72205	Recruiting
AME Clinical Research	Huntington Beach	California	92647	Recruiting
Amicis Research Center	Northridge	California	91325	Recruiting
FOMAT - Vista del Mar Medical Group	Oxnard	California	93036	Recruiting
Central Coast Nephrology	Salinas	California	93901	Recruiting
North America Research Institute	San Dimas	California	91773	Recruiting
Amicis Research Center	Santa Clarita	California	91355	Recruiting
Valiance Clinical Research	Tarzana	California	91356	Recruiting
Amicis Research Center	Valencia	California	91355	Recruiting
National Institute of Clinical Research, Inc.	Victorville	California	92392	Recruiting
D&H Doral Research Center	Doral	Florida	33122	Recruiting
AGA Clinical Trials	Hialeah	Florida	33012	Recruiting
Convenient Medical Center	Hialeah	Florida	33013	Recruiting
Elixia Hollywood	Hollywood	Florida	33024	Recruiting
D&H Pompano Research Center	Margate	Florida	33063	Recruiting
LCC Medical Research Institute	Miami	Florida	33126	Recruiting
D&H National Research Centers, Inc	Miami	Florida	33155	Recruiting
Regenerate Primary Medical Research, LLC	Miami	Florida	33155	Recruiting
Ocean Blue Medical Research Center - Internal Medicine	Miami Springs	Florida	33166	Recruiting
Innovia Research Center	Miramar	Florida	33027	Recruiting
Bolanos Clinical Research	Pembroke Pines	Florida	33026	Recruiting
Progressive Medical Research	Port Orange	Florida	32127	Recruiting
CDC Research Institute	Port Saint Lucie	Florida	34952	Recruiting
D&H Tamarac Research Center	Tamarac	Florida	33321	Recruiting
Metabolic Research Institute	West Palm Beach	Florida	33401	Recruiting
Privia Medical Group of Georgia, LLC	Savannah	Georgia	31406	Recruiting
Research by Design, LLC - Internal Medicine	Chicago	Illinois	60643	Recruiting
Elixia Michigan Kidney Consultants	Pontiac	Michigan	48341	Recruiting
Elixia MNA	City of Saint Peters	Missouri	63376	Recruiting
Clinical Research Consultants, LLC	Kansas City	Missouri	64111	Recruiting
DaVita Clinical Research	Las Vegas	Nevada	89107	Recruiting
Velocity Clinical Research	Binghamton	New York	13905	Recruiting
CHEAR Center LLC	The Bronx	New York	10455	Recruiting
Brookview Hills Research Associates, LLC	Winston-Salem	North Carolina	27103	Recruiting
Northeast Clinical Research Center	Bethlehem	Pennsylvania	18017	Recruiting
Suburban Research Associates	West Chester	Pennsylvania	19380	Recruiting
Southeast Renal Research Institute	Chattanooga	Tennessee	37404	Recruiting
Arlington Nephrology, PLLC.	Arlington	Texas	76015	Recruiting
M3 Wake Research Dallas - Internal Medicine	Dallas	Texas	75224	Recruiting
El Paso Kidney Specialists-Davita Clinical Research	El Paso	Texas	79902	Recruiting
Juno Research, LLC	Houston	Texas	77040	Recruiting
Clinical Trial Network, LLC	Houston	Texas	77074	Recruiting
Gulf Coast Clinical Research	Katy	Texas	77450	Recruiting
R & H Clinical Research, Inc.	Katy	Texas	77450	Recruiting
Sunbeam Clinical Research	McKinney	Texas	75069	Recruiting
Clinical Advancement Center	San Antonio	Texas	78212	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07271186, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 27, 2026 · Synced May 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07271186 live on ClinicalTrials.gov.

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