Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations

ClinicalTrials.gov ID: NCT07275359

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to investigate the safety and tolerability of Metformin and how it changes blood markers associated with aging in persons who have chronic obstructive pulmonary disease (COPD) who do not have diabetes.

Study identification

NCT ID: NCT07275359
Recruitment status: Not yet recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Duke University; Other
Enrollment: 45 participants

Conditions and interventions

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Interventions

Metformin Drug

Drug

Eligibility (public fields only)

Age range: 65 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 1, 2027 (Estimated)
Primary completion: Feb 1, 2029 (Estimated)
Completion: Oct 1, 2030 (Estimated)
Last update posted: Nov 3, 2026

2027 – 2030

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Duke Asthma, Allergy, and Airway Center	Durham	North Carolina	27705	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07275359, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 3, 2026 · Synced Nov 15, 2026