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Recruiting Phase 3 Interventional

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

ClinicalTrials.gov ID: NCT07276399

Public ClinicalTrials.gov record NCT07276399. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 7:17 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Open-Label, Multicenter Study of Amivantamab in Addition to Carboplatin and Pembrolizumab, Compared to Standard of Care Platinum and Pembrolizumab and 5-FU, in Participants With Treatment-Naïve Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Study identification

NCT ID
NCT07276399
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Janssen Research & Development, LLC
Industry
Enrollment
500 participants

Conditions and interventions

Interventions

  • 5-Flurouracil Drug
  • Amivantamab Biological
  • Carboplatin Drug
  • Cisplatin Drug
  • Pembrolizumab Biological

Drug · Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 2, 2025
Primary completion
Jun 17, 2029
Completion
Jun 17, 2029
Last update posted
May 7, 2026

2025 – 2029

United States locations

U.S. sites
38
U.S. states
20
U.S. cities
36
Facility City State ZIP Site status
Ironwood Cancer and Research Center Chandler Arizona 85224 Recruiting
Providence St Jude Medical Center Fullerton California 92835 Recruiting
Valkyrie Clinical Trials Los Angeles California 90067 Recruiting
Valkyrie Clinical Trials Murrieta Murrieta California 92562 Recruiting
Stanford University Medical Center Stanford California 94304 Recruiting
Hartford Hospital Hartford Connecticut 06102 Recruiting
Yale Cancer Center New Haven Connecticut 06510 Recruiting
Florida Cancer Specialists South Fort Myers Florida 33901 Recruiting
University of Miami Sylvester Comprehensive Cancer Center Miami Florida 33136 Recruiting
Florida Cancer Specialists North Region St. Petersburg Florida 33701-4553 Recruiting
Florida Cancer Specialists East West Palm Beach Florida 33401-3406 Recruiting
Emory University Atlanta Georgia 30308 Recruiting
Central Georgia Cancer Care Macon Georgia 31210 Recruiting
Rush University Medical Center Rush University Cancer Center Chicago Chicago Illinois 60607 Recruiting
The University of Chicago Medical Center (UCMC) Chicago Illinois 60637 Recruiting
Cancer Care Specialists of Central Illinois O'Fallon Illinois 62269 Recruiting
University of Kentucky Medical Center Lexington Kentucky 40536 Recruiting
Dana Farber Cancer Institute Boston Massachusetts 02115 Recruiting
Karmanos Cancer Institute Detroit Michigan 48201 2013 Recruiting
Washington University School Of Medicine St Louis Missouri 63108 Recruiting
NHO Revive Research Institute, LLC Lincoln Nebraska 68506 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Laura & Isaac Perlmutter Cancer Center at NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health New York New York 10016 Recruiting
Montefiore Medical Center The Bronx New York 10461 Recruiting
Bronx Veterans Affairs Medical Center The Bronx New York 10468 Recruiting
Carolina Cancer Research Center Wilson North Carolina 27893 Recruiting
University of Cincinnati Cincinnati Ohio 45219 Recruiting
Ohio State University Columbus Ohio 43210 Recruiting
Oregon Health And Science University Portland Oregon 97239 Recruiting
Tennessee Cancer Specialists Knoxville Tennessee 37909 Recruiting
UT Southwestern Medical Center Dallas Texas 75390 Recruiting
Texas Oncology - San Antonio Fredericksburg Texas 78624 Recruiting
MD Anderson Cancer Center Houston Texas 77030 Recruiting
Texas Oncology-Central South Waco Texas 76712 Recruiting
Huntsman Cancer Institute Salt Lake City Utah 84112 Recruiting
University of Virginia Charlottesville Virginia 22908 Recruiting
Virginia Cancer Specialists Fairfax Virginia 22031 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 139 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07276399, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 20, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07276399 live on ClinicalTrials.gov.

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