Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49
Public ClinicalTrials.gov record NCT07284654. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Active-Controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Subjects 50 Years of Age and Older With Immunobridging to Subjects 18-49 Years of Age
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objectives of this study are to evaluate the safety, tolerability, immunologic noninferiority (for shared serotypes) and immunologic superiority (for novel serotypes) of VAX-31 compared to PCV21 and PCV20 in adults ≥50 years of age, and to bridge the immune responses induced by VAX-31 in adults 50-64 years of age to adults 18-49 years of age.
Study identification
- NCT ID
- NCT07284654
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,049 participants
Conditions and interventions
Conditions
Interventions
- 31 valent pneumococcal conjugate vaccine Biological
- PCV20 Biological
- PCV21 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 1, 2025 (Actual)
- Primary completion
- Sep 17, 2026 (Actual)
- Completion
- Sep 17, 2026 (Actual)
- Last update posted
- Oct 16, 2026
2025 – 2026
United States locations
- U.S. sites
- 30
- U.S. states
- 22
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Accel Research Site - Achieve - Birmingham - ERN | Birmingham | Alabama | 35216 | — |
| Center for Indigenous Health - Chinle - Johns Hopkins Project | Chinle | Arizona | 86503 | — |
| Center for Indigineous Health - Whiteriver - John Hopkins Project | Whiteriver | Arizona | 85941 | — |
| Clinical Innovations Trials - Riverside - CenExel | Riverside | California | 92506 | — |
| Research Centers of America - Hollywood - CenExel | Hollywood | Florida | 33024 | — |
| Health Awareness - Jupiter - ERN | Jupiter | Florida | 33458 | — |
| Suncoast Research Group LLC | Miami | Florida | 33135 | — |
| Precision Clinical Research - Sunrise | Sunrise | Florida | 33351 | — |
| Clinical Research Atlanta - Headlands | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research - Valparaiso (Buynak Clinical Research) | Valparaiso | Indiana | 46383 | — |
| Johnson County Clin-Trials - JCCT | Lenexa | Kansas | 66219 | — |
| Alliance for Multispecialty Research, LLC - West Wichita | Wichita | Kansas | 67207 | — |
| DelRicht Clinical Research, LLC - New Orleans | New Orleans | Louisiana | 70115 | — |
| Headlands Research - Detroit - Headlands | Southfield | Michigan | 48034 | — |
| DelRicht Research, LLC - Gulfport | Gulfport | Mississippi | 39503 | — |
| Sky Integrative Medical Center - SKYCRNG | Ridgeland | Mississippi | 39157 | — |
| Alliance for Multispecialty Research, LLC - Kansas City | Kansas City | Missouri | 64114 | — |
| Velocity Clinical Research | Omaha | Nebraska | 68134 | — |
| Advanced Memory Research Institute - CenExe | Toms River | New Jersey | 08755 | — |
| Center for Indigineous Health - Gallup - John Hopkins Project | Gallup | New Mexico | 87301 | — |
| Center for Indigineous Health - Shiprock - John Hopkins Project | Shiprock | New Mexico | 87420 | — |
| Rochester Clinical Research - ATLAS - Rochester | Rochester | New York | 14609 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| DM Clinical Research - Philadelphia | Philadelphia | Pennsylvania | 19107 | — |
| Coastal Carolina Research Center - Alcanza - HyperCore | North Charleston | South Carolina | 29405 | — |
| Flourish Research - San Antonio | San Antonio | Texas | 78229 | — |
| DM Clinical Research - Sugarland | Sugar Land | Texas | 77478 | — |
| JBR Clinical Research - CenExel JBR | Salt Lake City | Utah | 84107 | — |
| Charlottesville Medical Research Center - Alcanza - HyperCore | Charlottesville | Virginia | 22911 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07284654, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 16, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07284654 live on ClinicalTrials.gov.