Safety, Tolerability, and Immunogenicity of VAX-31 in Adults ≥50 Years With Immunobridging to Adults 18-49
Public ClinicalTrials.gov record NCT07284654. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Active-Controlled Clinical Study to Evaluate the Safety, Tolerability, and Immunogenicity of VAX-31 in Healthy Subjects 50 Years of Age and Older With Immunobridging to Subjects 18-49 Years of Age
Study identification
- NCT ID
- NCT07284654
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Vaxcyte, Inc.
- Industry
- Enrollment
- 4,049 participants
Conditions and interventions
Conditions
Interventions
- 31 valent pneumococcal conjugate vaccine Biological
- PCV20 Biological
- PCV21 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2025
- Primary completion
- Dec 31, 2026
- Completion
- Dec 31, 2026
- Last update posted
- May 14, 2026
2025 – 2027
United States locations
- U.S. sites
- 30
- U.S. states
- 22
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Accel Research Site - Achieve - Birmingham - ERN | Birmingham | Alabama | 35216 | — |
| Center for Indigenous Health - Chinle - Johns Hopkins Project | Chinle | Arizona | 86503 | — |
| Center for Indigineous Health - Whiteriver - John Hopkins Project | Whiteriver | Arizona | 85941 | — |
| Clinical Innovations Trials - Riverside - CenExel | Riverside | California | 92506 | — |
| Research Centers of America - Hollywood - CenExel | Hollywood | Florida | 33024 | — |
| Health Awareness - Jupiter - ERN | Jupiter | Florida | 33458 | — |
| Suncoast Research Group LLC | Miami | Florida | 33135 | — |
| Precision Clinical Research - Sunrise | Sunrise | Florida | 33351 | — |
| Clinical Research Atlanta - Headlands | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research - Valparaiso (Buynak Clinical Research) | Valparaiso | Indiana | 46383 | — |
| Johnson County Clin-Trials - JCCT | Lenexa | Kansas | 66219 | — |
| Alliance for Multispecialty Research, LLC - West Wichita | Wichita | Kansas | 67207 | — |
| DelRicht Clinical Research, LLC - New Orleans | New Orleans | Louisiana | 70115 | — |
| Headlands Research - Detroit - Headlands | Southfield | Michigan | 48034 | — |
| DelRicht Research, LLC - Gulfport | Gulfport | Mississippi | 39503 | — |
| Sky Integrative Medical Center - SKYCRNG | Ridgeland | Mississippi | 39157 | — |
| Alliance for Multispecialty Research, LLC - Kansas City | Kansas City | Missouri | 64114 | — |
| Velocity Clinical Research | Omaha | Nebraska | 68134 | — |
| Advanced Memory Research Institute - CenExe | Toms River | New Jersey | 08755 | — |
| Center for Indigineous Health - Gallup - John Hopkins Project | Gallup | New Mexico | 87301 | — |
| Center for Indigineous Health - Shiprock - John Hopkins Project | Shiprock | New Mexico | 87420 | — |
| Rochester Clinical Research - ATLAS - Rochester | Rochester | New York | 14609 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| DM Clinical Research - Philadelphia | Philadelphia | Pennsylvania | 19107 | — |
| Coastal Carolina Research Center - Alcanza - HyperCore | North Charleston | South Carolina | 29405 | — |
| Flourish Research - San Antonio | San Antonio | Texas | 78229 | — |
| DM Clinical Research - Sugarland | Sugar Land | Texas | 77478 | — |
| JBR Clinical Research - CenExel JBR | Salt Lake City | Utah | 84107 | — |
| Charlottesville Medical Research Center - Alcanza - HyperCore | Charlottesville | Virginia | 22911 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07284654, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 14, 2026 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07284654 live on ClinicalTrials.gov.