A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
Public ClinicalTrials.gov record NCT07287098. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
preEMBER: A Phase 2, Open-label Study Evaluating Imlunestrant in Premenopausal Women With Estrogen Receptor-Positive, HER2-Negative Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will include two groups of patients: Cohort 1 and Cohort 2. Cohort 1: will help researchers learn how a medicine called imlunestrant (LY3484356) affects a specific type of breast cancer. Some patients will take both imlunestrant and another treatment to suppress their ovarian function. Some will take it without ovarian suppression. Researchers will compare the effects in breast cancer cells to those of another medicine called tamoxifen. All patients in this group will be premenopausal women who have a type of early breast cancer called estrogen receptor-positive, HER2-negative. The treatment in this group will last for up to 29 days. Cohort 2: will help researchers understand how imlunestrant affects the ovaries when it is taken without ovarian suppression. Researchers will compare the effects to those of another medicine called tamoxifen. This group will also include premenopausal women with the same type of breast cancer. The treatment in this group will last for up to 6 months.
Study identification
- NCT ID
- NCT07287098
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 13, 2026 (Actual)
- Primary completion
- Jan 2029 (Estimated)
- Completion
- Dec 2029 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2029
United States locations
- U.S. sites
- 34
- U.S. states
- 20
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35205 | Not yet recruiting |
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | Not yet recruiting |
| Mayo Clinic in Arizona - Phoenix | Phoenix | Arizona | 85054 | Not yet recruiting |
| City of Hope | Duarte | California | 91010 | Not yet recruiting |
| City of Hope Orange County Lennar Foundation Cancer Center | Irvine | California | 92618 | Not yet recruiting |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Not yet recruiting |
| UCLA Hematology/Oncology - Parkside | Santa Monica | California | 90404 | Not yet recruiting |
| Banner MD Anderson Cancer Center at North Colorado Medical Center | Greeley | Colorado | 80631 | Not yet recruiting |
| Banner MD Anderson Cancer Center at McKee Medical Center | Loveland | Colorado | 80538 | Not yet recruiting |
| AdventHealth Altamonte Springs | Altamonte Springs | Florida | 32701 | Not yet recruiting |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | Not yet recruiting |
| Winship Cancer Institute | Atlanta | Georgia | 30322 | Not yet recruiting |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | Not yet recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Not yet recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Not yet recruiting |
| Mayo Clinic in Rochester, Minnesota | Rochester | Minnesota | 55905 | Not yet recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Not yet recruiting |
| Wilmot Cancer Institute | Rochester | New York | 14642 | Not yet recruiting |
| New York Cancer and Blood Specialists | Shirley | New York | 11967 | Recruiting |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Suspended |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Not yet recruiting |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | Not yet recruiting |
| Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4009 | Recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Not yet recruiting |
| Oncology Consultants P.A. | Houston | Texas | 77030 | Recruiting |
| Baylor Scott & White Medical Center - Round Rock | Round Rock | Texas | 78665 | Not yet recruiting |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | Not yet recruiting |
| The University of Vermont Medical Center Inc. | Burlington | Vermont | 05401 | Not yet recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | Not yet recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07287098, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07287098 live on ClinicalTrials.gov.