Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

ClinicalTrials.gov ID: NCT07291037

Public ClinicalTrials.gov record NCT07291037. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 5:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Randomised, Open-Label, Multicentre Study of Datopotamab Deruxtecan or Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous Non-Small Cell Lung Cancer Without Actionable Genomic Alterations (TROPION-Lung17)

Study identification

NCT ID: NCT07291037
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 400 participants

Conditions and interventions

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

Datopotamab deruxtecan (Dato-DXd) Drug
Docetaxel Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 30, 2025
Primary completion: Jan 28, 2029
Completion: Jan 28, 2029
Last update posted: Apr 28, 2026

2025 – 2029

United States locations

U.S. sites: 50
U.S. states: 27
U.S. cities: 49

Facility	City	State	ZIP	Site status
Research Site	Chandler	Arizona	85224	Recruiting
Research Site	Gilbert	Arizona	85234	Recruiting
Research Site	Goodyear	Arizona	85338	Recruiting
Research Site	Duarte	California	91010	Recruiting
Research Site	Irvine	California	92618	Recruiting
Research Site	La Jolla	California	92093	Recruiting
Research Site	Loma Linda	California	92350	Recruiting
Research Site	Los Angeles	California	90095	Not yet recruiting
Research Site	San Diego	California	92123	Recruiting
Research Site	Grand Junction	Colorado	81501	Recruiting
Research Site	Wheat Ridge	Colorado	80033	Recruiting
Research Site	Newark	Delaware	19713	Not yet recruiting
Research Site	Washington D.C.	District of Columbia	20037	Not yet recruiting
Research Site	Fort Myers	Florida	33901	Not yet recruiting
Research Site	Jacksonville	Florida	32224	Recruiting
Research Site	St. Petersburg	Florida	33709	Recruiting
Research Site	Tampa	Florida	33612	Recruiting
Research Site	West Palm Beach	Florida	33401	Not yet recruiting
Research Site	Marietta	Georgia	30060	Recruiting
Research Site	Newnan	Georgia	30265	Recruiting
Research Site	Chicago	Illinois	60612	Not yet recruiting
Research Site	Chicago	Illinois	60637	Recruiting
Research Site	Niles	Illinois	60714	Recruiting
Research Site	Zion	Illinois	60099	Recruiting
Research Site	Louisville	Kentucky	40207	Recruiting
Research Site	South Portland	Maine	04106	Not yet recruiting
Research Site	Baltimore	Maryland	21201	Recruiting
Research Site	Brandywine	Maryland	20613	Recruiting
Research Site	Boston	Massachusetts	02215	Recruiting
Research Site	Detroit	Michigan	48202	Recruiting
Research Site	Rochester	Minnesota	55905	Recruiting
Research Site	Bridgeton	Missouri	63044	Recruiting
Research Site	Columbia	Missouri	65212	Withdrawn
Research Site	Lincoln	Nebraska	68516	Recruiting
Research Site	Albuquerque	New Mexico	87109	Recruiting
Research Site	East Syracuse	New York	13057	Recruiting
Research Site	Portland	Oregon	97239	Withdrawn
Research Site	Hershey	Pennsylvania	17033	Recruiting
Research Site	Philadelphia	Pennsylvania	19104	Not yet recruiting
Research Site	Greenville	South Carolina	29607	Recruiting
Research Site	Memphis	Tennessee	38120	Recruiting
Research Site	Austin	Texas	78745	Recruiting
Research Site	Denton	Texas	76201	Recruiting
Research Site	Plano	Texas	75075	Recruiting
Research Site	Charlottesville	Virginia	22908	Recruiting
Research Site	Fairfax	Virginia	22031	Recruiting
Research Site	Williamsburg	Virginia	23188	Recruiting
Research Site	Tacoma	Washington	98405	Recruiting
Research Site	Morgantown	West Virginia	26506	Recruiting
Research Site	Eau Claire	Wisconsin	54703	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 154 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07291037, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 28, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07291037 live on ClinicalTrials.gov.

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