PREcision MEDicine In Achalasia (PREMEDIA)
Public ClinicalTrials.gov record NCT07293650. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Study identification
- NCT ID
- NCT07293650
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 372 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2026
- Primary completion
- Jul 31, 2031
- Completion
- Jul 31, 2032
- Last update posted
- Aug 27, 2026
2026 – 2032
United States locations
- U.S. sites
- 16
- U.S. states
- 14
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | Not yet recruiting |
| University of California San Diego | La Jolla | California | 92093 | Not yet recruiting |
| University of Colorado Denver | Denver | Colorado | 80217 | Not yet recruiting |
| University of Florida | Gainesville | Florida | 32611 | Recruiting |
| Adventist Health System/Sunbelt, Inc | Orlando | Florida | 32803 | Not yet recruiting |
| Emory University | Atlanta | Georgia | 30322 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21218 | Not yet recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Washington University | St Louis | Missouri | 63130 | Not yet recruiting |
| Weill Cornell Medical College | New York | New York | 10065 | Not yet recruiting |
| Atrium Health/Wake Forest | Charlotte | North Carolina | 28204 | Recruiting |
| Case Western Reserve University | Cleveland | Ohio | 44106 | Not yet recruiting |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Recruiting |
| Baylor Scott & White Health | Dallas | Texas | 75204 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07293650, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07293650 live on ClinicalTrials.gov.