Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
Public ClinicalTrials.gov record NCT07311850. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Evaluating The Efficacy and Safety of MET097, a Fully-Biased, Ultra Long-Acting GLP-1RA, In People With Overweight or Obesity: A Phase 3, Multi-Center Randomized, Controlled Trial (VESPER-4)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.
Study identification
- NCT ID
- NCT07311850
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,578 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 19, 2025 (Actual)
- Primary completion
- Sep 21, 2027 (Estimated)
- Completion
- Apr 25, 2028 (Estimated)
- Last update posted
- Oct 13, 2026
2025 – 2028
United States locations
- U.S. sites
- 37
- U.S. states
- 15
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Headlands Research | Scottsdale | Arizona | 85260 | — |
| Alliance Research Institute | Canoga Park | California | 91304 | — |
| Rolling Oaks Radiology -Palms | Oxnard | California | 93036 | — |
| Clinical Innovations, Inc dba CITrials | Riverside | California | 92506 | — |
| Peninsula Headlands LLC | Rolling Hills | California | 90274 | — |
| Collaborative Neuroscience Research, LLC | Torrance | California | 90504 | — |
| CenExcel Rocky Mountain Clinical Research, LLC | Englewood | Colorado | 80113 | — |
| Research Centers of America | Hollywood | Florida | 33024 | — |
| Future Medical Research (Civia Health) | Longwood | Florida | 32750 | — |
| Advanced Clinical Research | Miami | Florida | 33156 | — |
| Oviedo Medical Research | Oviedo | Florida | 32765 | — |
| CenExel FCR - ForCare Clinical Research | Tampa | Florida | 33613 | — |
| DelRicht Research | Atlanta | Georgia | 30329 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| CenExel CBH Health | Gaithersburg | Maryland | 20877 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| Upgrade Performance Institute | Elkhorn | Nebraska | 68022 | — |
| Quality Clinical Research Inc | Omaha | Nebraska | 68114 | — |
| Primary Care Research (Civia Health) | Papillion | Nebraska | 68046 | — |
| Hassman Research Institute | Marlton | New Jersey | 08053 | — |
| Forum Health_Cary (Civia) | Cary | North Carolina | 27511 | — |
| Eximia EquiHealth Research | Durham | North Carolina | 27704 | — |
| Sahana Optometry PLLC dba Family Eye Wellness | Holly Springs | North Carolina | 27540 | — |
| TMA Headlands LLC - Wilmington | Wilmington | North Carolina | 28403 | — |
| TMA Headlands LLC | Wilmington | North Carolina | 28403 | — |
| Summit Headlands LLC | Portland | Oregon | 97210 | — |
| Tribe Clinical Research LLC.- Greenville | Greenville | South Carolina | 29607 | — |
| Palmetto Internal Medicine | Mauldin | South Carolina | 29662 | — |
| Tribe Clinical Research LLC. - Spartanburg | Spartanburg | South Carolina | 29301 | — |
| Civia Health Goodlettsville | Goodlettsville | Tennessee | 37072 | — |
| Civia Health Nashville | La Vergne | Tennessee | 37086 | — |
| Civia Health Memphis | Memphis | Tennessee | 38117 | — |
| Forum Austin (Civia Health) | Austin | Texas | 78758 | — |
| Cedar Health Research | Dallas | Texas | 75251 | — |
| GLRI El Paso Research | El Paso | Texas | 79936 | — |
| Dallas Clinical Research Center (Pillar Clinical Research) | Richardson | Texas | 75080 | — |
| Pantheon Clinical Research | Bountiful | Utah | 84010 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 124 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07311850, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07311850 live on ClinicalTrials.gov.