Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
Public ClinicalTrials.gov record NCT07311850. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Evaluating The Efficacy and Safety of MET097, a Fully-Biased, Ultra Long-Acting GLP-1RA, In People With Overweight or Obesity: A Phase 3, Multi-Center Randomized, Controlled Trial (VESPER-4)
Study identification
- NCT ID
- NCT07311850
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Metsera, a wholly owned subsidiary of Pfizer
- Industry
- Enrollment
- 3,500 participants
Conditions and interventions
Conditions
Interventions
- MET097 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2025
- Primary completion
- Aug 31, 2027
- Completion
- Apr 30, 2028
- Last update posted
- Apr 20, 2026
2025 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 16
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Headlands Research | Scottsdale | Arizona | 85260 | Recruiting |
| Alliance Research Institute | Canoga Park | California | 91304 | Recruiting |
| Clinical Innovations, Inc dba CITrials | Riverside | California | 92506 | Recruiting |
| Peninsula Headlands LLC | Rolling Hills | California | 90274 | Recruiting |
| Collaborative Neuroscience Research, LLC | Torrance | California | 90504 | Recruiting |
| CenExcel Rocky Mountain Clinical Research, LLC | Englewood | Colorado | 80113 | Recruiting |
| Research Centers of America | Hollywood | Florida | 33024 | Recruiting |
| Future Medical Research (Civia Health) | Longwood | Florida | 32750 | Recruiting |
| Advanced Clinical Research | Miami | Florida | 33156 | Recruiting |
| Oviedo Medical Research | Oviedo | Florida | 32765 | Recruiting |
| CenExel FCR - ForCare Clinical Research | Tampa | Florida | 33613 | Recruiting |
| DelRicht Research @ Springer Wellness and Restorative Health | Atlanta | Georgia | 30329 | Recruiting |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | Recruiting |
| CenExel CBH Health | Gaithersburg | Maryland | 20877 | Recruiting |
| Civia Health Shelby | Shelby | Michigan | 48315 | Not yet recruiting |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | Recruiting |
| Civia Health St. Louis | Creve Coeur | Missouri | 63141 | Not yet recruiting |
| Civia Health Independence | Independence | Missouri | 64055 | Not yet recruiting |
| Quality Clinical Research Inc | Omaha | Nebraska | 68114 | Recruiting |
| Primary Care Research (Civia Health) | Papillion | Nebraska | 68046 | Recruiting |
| CenExel HRI - Hassman Research Institute | Marlton | New Jersey | 08053 | Recruiting |
| Forum Health Cary | Cary | North Carolina | 27511 | Recruiting |
| Eximia EquiHealth Research | Durham | North Carolina | 27704 | Recruiting |
| TMA Headlands LLC | Wilmington | North Carolina | 28403 | Recruiting |
| Summit Headlands LLC | Portland | Oregon | 97210 | Recruiting |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | Recruiting |
| Tribe Clinical Research, LLC | Spartanburg | South Carolina | 29301 | Recruiting |
| Civia Health Goodlettsville | Goodlettsville | Tennessee | 37072 | Recruiting |
| Civia Health Nashville | La Vergne | Tennessee | 37086 | Recruiting |
| Civia Health Memphis | Memphis | Tennessee | 38117 | Not yet recruiting |
| Forum Austin (Civia Health) | Austin | Texas | 78578 | Recruiting |
| Cedar Health Research | Dallas | Texas | 75251 | Not yet recruiting |
| GLRI El Paso Research | El Paso | Texas | 79936 | Recruiting |
| Dallas Clinical Research Center (Pillar Clinical Research) | Richardson | Texas | 75080 | Recruiting |
| Pantheon Clinical Research | Bountiful | Utah | 84010 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 161 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07311850, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced Apr 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07311850 live on ClinicalTrials.gov.