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Recruiting Phase 3 Interventional

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

ClinicalTrials.gov ID: NCT07326709

Public ClinicalTrials.gov record NCT07326709. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 11, 2026, 11:48 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Placebo-controlled, Double-blind Phase 3 Study to Evaluate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose is to assess safety and tolerability of votoplam and to determine whether votoplam slows disease progression in patients with early symptomatic Huntington's disease (HD) compared to the control arm. HTT227 - current compound code (former code is PTC518 from PTC Therapeutics), HTT227 is Novartis code under Novartis sponsorship.

Study identification

NCT ID
NCT07326709
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
770 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
21 Years to 70 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 23, 2026
Primary completion
Apr 1, 2030
Completion
Apr 29, 2030
Last update posted
Aug 30, 2026

2026 – 2030

United States locations

U.S. sites
34
U.S. states
24
U.S. cities
34
Facility City State ZIP Site status
University of Alabama Birmingham Birmingham Alabama 35233 Recruiting
Univ of Arkansas for Med Sciences Little Rock Arkansas 72205 Recruiting
University of CA San Diego La Jolla California 92037 Recruiting
UC Davis Health System Sacramento California 95817 Recruiting
Stanford Healthcare Stanford California 94305-5152 Recruiting
CenExcel Rocky Mtn Clin Research Englewood Colorado 80113 Recruiting
U Conn Health Farmington Connecticut 06030 Recruiting
Georgetown University Washington D.C. District of Columbia 20007 Recruiting
University Of South Florida Tampa Florida 33612 Recruiting
Grady Memorial Hospital and Clinics Atlanta Georgia 30303 Recruiting
Parkinsons-Movement Disorder Ctr Chicago Illinois 60611 Recruiting
Indiana University Health Indianapolis Indiana 46202 Recruiting
University of Iowa Health Care Iowa City Iowa 52242-1091 Recruiting
University of Kansas Hospital Fairway Kansas 66205 Recruiting
Beth Israel Deaconess Med Ctr Boston Massachusetts 02215 Recruiting
Henry Ford Health System Detroit Michigan 48202 Recruiting
Trinity Health Michigan Grand Rapids Michigan 49503 Recruiting
Albany Medical College Albany New York 12208 Recruiting
UBMD Neurology Buffalo New York 14202 Recruiting
Columbia University Irving Medical New York New York 10032 Recruiting
Universi of Rochester School of Med Rochester New York 14609 Recruiting
University Of NC At Chapel Hill Chapel Hill North Carolina 27599-9500 Recruiting
Duke University Health System Durham North Carolina 27710 Recruiting
Cleveland Clinic Foundation Cleveland Ohio 44195 Recruiting
University of Pennsylvania Philadelphia Pennsylvania 19107 Recruiting
University Of Pittsburgh Pittsburgh Pennsylvania 15213 Recruiting
Veracity Neuroscience LLC Memphis Tennessee 38157 Recruiting
Vanderbilt University Medical CenterX Nashville Tennessee 37221 Recruiting
TX Movement Disorder Spec PLLC Georgetown Texas 78628 Recruiting
U of TX Health Science Ct Houston Texas 77030 Recruiting
The University of Vermont MC Burlington Vermont 05401 Recruiting
VCU Health Systems MCV Richmond Virginia 23298 Recruiting
University of Washington Medical Center Seattle Washington 98195 Recruiting
Uni Of Wisconsin Hosp And Clinic Madison Wisconsin 53705-3611 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 48 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07326709, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 30, 2026 · Synced Sep 11, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07326709 live on ClinicalTrials.gov.

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