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Recruiting Phase 3 Interventional

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

ClinicalTrials.gov ID: NCT07353931

Public ClinicalTrials.gov record NCT07353931. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 3, 2026, 6:00 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Study identification

NCT ID
NCT07353931
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Eli Lilly and Company
Industry
Enrollment
900 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 8, 2026
Primary completion
Feb 29, 2028
Completion
Apr 30, 2028
Last update posted
Aug 20, 2026

2026 – 2028

United States locations

U.S. sites
38
U.S. states
19
U.S. cities
36
Facility City State ZIP Site status
AMR Clinical Mobile Alabama 36608 Recruiting
Care Access - 801 South Power Road, Mesa Mesa Arizona 85206 Recruiting
Elite Pain and Spine Institute - South Crimson Road Mesa Arizona 85209 Recruiting
Elite Clinical Studies, LLC Phoenix Arizona 85018 Recruiting
Tucson Orthopaedic Institute - North Wyatt Drive Tucson Arizona 85712 Recruiting
Ark Clinical Research - Fountain Valley Fountain Valley California 92708 Recruiting
Wolverine Clinical Trials Santa Ana California 92706 Recruiting
Encompass Clinical Research Spring Valley California 91978 Recruiting
Diablo Clinical Research, Inc. Walnut Creek California 94598 Recruiting
Skylight Health Research - Colorado Springs Colorado Springs Colorado 80917 Recruiting
Westside Center for Clinical Research Jacksonville Florida 32205 Recruiting
Care Access - St. Petersburg St. Petersburg Florida 33710 Recruiting
Conquest Research Winter Park Florida 32789 Recruiting
Orita Clinical Research Decatur Georgia 30034 Recruiting
Medical Research Partners Ammon Idaho 83406 Recruiting
Great Lakes Clinical Trials - Ravenswood Chicago Illinois 60640 Recruiting
Qualmedica Research, LLC Evansville Indiana 47715 Recruiting
AMR Clinical Newton Kansas 67114 Recruiting
Monroe Biomedical Research - Louisville Louisville Kentucky 40213 Recruiting
Skylight Health Research - Burlington Burlington Massachusetts 01803 Recruiting
Care Access - Quincy Quincy Massachusetts 02169 Recruiting
Ellipsis Research Group - Brooklyn - 7th Street Brooklyn New York 11215 Recruiting
Rochester Clinical Research - Buffalo Buffalo New York 14127 Recruiting
NYC Research INC Long Island City New York 11106 Recruiting
Rochester Clinical Research, LLC Rochester New York 14609 Recruiting
Central States Research Tulsa Oklahoma 74136 Recruiting
Keystone Clinical Studies Plymouth Meeting Pennsylvania 19462 Recruiting
JCCT - Juno Bellaire Site Bellaire Texas 77401 Recruiting
Epic Medical Research - DeSoto DeSoto Texas 75115 Recruiting
Valley Institute of Research - Fort Worth Fort Worth Texas 76164 Recruiting
Care Access - Houston Houston Texas 77054 Recruiting
VIP Trials San Antonio Texas 78230 Recruiting
Endeavor Clinical Trials San Antonio Texas 78240 Recruiting
Consano Clinical Research, LLC Shavano Park Texas 78231 Recruiting
Texas Valley Clinical Research Weslaco Texas 78596 Recruiting
AMR Clinical South Jordan Utah 84095 Recruiting
Charlottesville Medical Research Charlottesville Virginia 22911 Recruiting
Paramount Clinical Research - Data Point Clinical Research Kirkland Washington 98034 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07353931, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 20, 2026 · Synced Sep 3, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07353931 live on ClinicalTrials.gov.

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