Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
Public ClinicalTrials.gov record NCT07353931. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)
Study identification
- NCT ID
- NCT07353931
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 900 participants
Conditions and interventions
Conditions
Interventions
- Eloralintide Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 8, 2026
- Primary completion
- Feb 29, 2028
- Completion
- Apr 30, 2028
- Last update posted
- Apr 16, 2026
2026 – 2028
United States locations
- U.S. sites
- 34
- U.S. states
- 15
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMR Clinical | Mobile | Alabama | 36608 | Recruiting |
| Care Access - 801 South Power Road, Mesa | Mesa | Arizona | 85206 | Recruiting |
| Elite Pain and Spine Institute - South Crimson Road | Mesa | Arizona | 85209 | Recruiting |
| Tucson Orthopaedic Institute - North Wyatt Drive | Tucson | Arizona | 85712 | Recruiting |
| Ark Clinical Research - Fountain Valley | Fountain Valley | California | 92708 | Recruiting |
| Wolverine Clinical Trials | Santa Ana | California | 92706 | Recruiting |
| Encompass Clinical Research | Spring Valley | California | 91978 | Recruiting |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | Recruiting |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | Recruiting |
| Care Access - St. Petersburg | St. Petersburg | Florida | 33710 | Recruiting |
| Conquest Research | Winter Park | Florida | 32789 | Recruiting |
| Orita Clinical Research | Decatur | Georgia | 30034 | Recruiting |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | Recruiting |
| Qualmedica Research, LLC | Evansville | Indiana | 47715 | Recruiting |
| AMR Clinical | Newton | Kansas | 67114 | Recruiting |
| L-MARC Research Center | Louisville | Kentucky | 40213 | Recruiting |
| Skylight Health Research - Burlington | Burlington | Massachusetts | 01803 | Recruiting |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | Not yet recruiting |
| Ellipsis Research Group - Brooklyn - 7th Street | Brooklyn | New York | 11215 | Recruiting |
| Rochester Clinical Research - Buffalo | Buffalo | New York | 14127 | Recruiting |
| NYC Research INC | Long Island City | New York | 11106 | Recruiting |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | Recruiting |
| Central States Research | Tulsa | Oklahoma | 74136 | Recruiting |
| Heritage Valley Multispecialty Group, Inc | Beaver | Pennsylvania | 15009 | Not yet recruiting |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| JCCT - Juno Bellaire Site | Bellaire | Texas | 77401 | Recruiting |
| Epic Medical Research - DeSoto | DeSoto | Texas | 75115 | Recruiting |
| Valley Institute of Research - Fort Worth | Fort Worth | Texas | 76164 | Recruiting |
| Care Access - Houston | Houston | Texas | 77054 | Recruiting |
| VIP Trials | San Antonio | Texas | 78230 | Recruiting |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | Recruiting |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | Recruiting |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | Recruiting |
| AMR Clinical | South Jordan | Utah | 84095 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07353931, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07353931 live on ClinicalTrials.gov.