An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.
Public ClinicalTrials.gov record NCT07357597. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IV, Open-Label, Single-Arm Study of Prophylaxis for Datopotamab Deruxtecan-related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer (TROPION-SWISH)
Study identification
- NCT ID
- NCT07357597
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- AstraZeneca
- Industry
- Enrollment
- 100 participants
Conditions and interventions
Conditions
Interventions
- Datopotamab Deruxtecan (Dato-DXd) Drug
- Dexamethasone mouthwash Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 26, 2026
- Primary completion
- Oct 8, 2027
- Completion
- Oct 8, 2027
- Last update posted
- Jan 21, 2026
2026 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 15
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Tucson | Arizona | 85719 | — |
| Research Site | Hot Springs | Arkansas | 71913 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Duarte | California | 91010 | — |
| Research Site | Glendale | California | 91204 | — |
| Research Site | Lakewood | California | 90805 | — |
| Research Site | Torrance | California | 90505 | — |
| Research Site | Athens | Georgia | 30607 | — |
| Research Site | Park Ridge | Illinois | 60068 | — |
| Research Site | Fort Wayne | Indiana | 46825 | — |
| Research Site | Lexington | Kentucky | 40503 | — |
| Research Site | Louisville | Kentucky | 40207 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Reno | Nevada | 89502 | — |
| Research Site | Westbury | New York | 11590 | — |
| Research Site | Greensboro | North Carolina | 27403 | — |
| Research Site | Cleveland | Ohio | 44106 | — |
| Research Site | Knoxville | Tennessee | 37920 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Milwaukee | Wisconsin | 64111 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07357597, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07357597 live on ClinicalTrials.gov.