A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate to Severe Chronic Obstructive Pulmonary Disease
Public ClinicalTrials.gov record NCT07363694. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL PHASE 2/3, RANDOMIZED, DOUBLE-BLIND, THIRD PARTY-UNBLINDED, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY TO INVESTIGATE EFFICACY AND SAFETY OF PF-07275315 IN ADULT PARTICIPANTS WITH MODERATE-TO-SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.
Study identification
- NCT ID
- NCT07363694
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 1,156 participants
Conditions and interventions
Interventions
- PF-07275315 dose 1 Drug
- PF-07275315-dose 2 Drug
- Placebo Drug
- PF-07275315-dose 3 Drug
Drug
Eligibility (public fields only)
- Age range
- 35 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 10, 2026
- Primary completion
- Oct 23, 2030
- Completion
- Jan 15, 2031
- Last update posted
- Aug 30, 2026
2026 – 2031
United States locations
- U.S. sites
- 61
- U.S. states
- 21
- U.S. cities
- 51
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Lung Health Center | Birmingham | Alabama | 35233 | Recruiting |
| SEC Clinical Research | Dothan | Alabama | 36305 | Recruiting |
| Pulmonary Associates of Mobile, P.C. | Mobile | Alabama | 36608 | Recruiting |
| Chandler Clinical Trials | Chandler | Arizona | 85224 | Not yet recruiting |
| Pulmonary Associates, PA | Phoenix | Arizona | 85027 | Recruiting |
| IMAX Clinical Trials | La Palma | California | 90623 | Recruiting |
| NewportNativeMD, Inc. | Newport Beach | California | 92663 | Recruiting |
| California Medical Research Associates | Northridge | California | 91324 | Recruiting |
| Institute of HealthCare Assessment d/b/a Apex Clinical Research | San Diego | California | 92120 | Recruiting |
| Finlay Medical Research | Greenacres City | Florida | 33467 | Recruiting |
| Clinical Research Specialists LLC | Kissimmee | Florida | 34746 | Recruiting |
| Advanced Pulmonary Research Institute | Loxahatchee Groves | Florida | 33470 | Recruiting |
| Reed Medical Research | Miami | Florida | 33176 | Recruiting |
| Renstar Medical Research | Ocala | Florida | 34470 | Recruiting |
| HCA Florida Ocala Imaging Center | Ocala | Florida | 34471 | Recruiting |
| Ocala Lung and Critical Care Associates | Ocala | Florida | 34471 | Recruiting |
| Renstar Medical Research | Ocala | Florida | 34471 | Recruiting |
| Coastal Medical Research Institute, LLC | St. Petersburg | Florida | 33704 | Recruiting |
| Coastal Pulmonary and Critical Care, P.L.C | St. Petersburg | Florida | 33704 | Recruiting |
| Clinical Research Trials of Florida, Inc. | Tampa | Florida | 33607 | Recruiting |
| Clinical Site Partners, LLC dba Flourish Research | Winter Park | Florida | 32789 | Recruiting |
| Cpcc-Research Llc | East Point | Georgia | 30344 | Recruiting |
| Centricity Research Rincon Pulmonology | Rincon | Georgia | 31326 | Recruiting |
| ASHA Clinical Research - Munster, LLC | Hammond | Indiana | 46324 | Recruiting |
| Methodist Hospital Southlake | Merrillville | Indiana | 46410 | Recruiting |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | Not yet recruiting |
| Southern Clinical Research, LLC | Zachary | Louisiana | 70791 | Recruiting |
| Paul A. Shapero, MD, PA | Bangor | Maine | 04401 | Not yet recruiting |
| Exordia Medical Research Inc. | Fall River | Massachusetts | 02723 | Not yet recruiting |
| Infinity Medical Research | North Dartmouth | Massachusetts | 02747 | Not yet recruiting |
| Revival Research Institute, LLC | Dearborn | Michigan | 48126 | Recruiting |
| AA Medical Research Center | Flint | Michigan | 48504 | Recruiting |
| Revive Research Institute, Inc. | Southfield | Michigan | 48075 | Recruiting |
| Oakland Medical Research | Troy | Michigan | 48085 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63108 | Recruiting |
| Barnes-Jewish Hospital Investigational Drug Service | St Louis | Missouri | 63110 | Recruiting |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Washington University School-Cardiovascular Imaging and Clinical Research Core Laboratory | St Louis | Missouri | 63110 | Recruiting |
| Henderson Clinical Trials | Henderson | Nevada | 89052 | Recruiting |
| Northwell Health Physician Partners at Chappaqua | Chappaqua | New York | 10514 | Not yet recruiting |
| New York Presbyterian Queens | Flushing | New York | 11355 | Not yet recruiting |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | Not yet recruiting |
| Salem Chest Specialists | Winston-Salem | North Carolina | 27103 | Recruiting |
| Southeastern Research Center | Winston-Salem | North Carolina | 27103 | Recruiting |
| Toledo Institute of Clinical Research Inc. | Toledo | Ohio | 43617 | Not yet recruiting |
| Clinical Research Associates of Central PA, LLC | DuBois | Pennsylvania | 15801 | Recruiting |
| Bogan Sleep Consultants, LLC | Columbia | South Carolina | 29201 | Recruiting |
| Velocity Clinical Research, Gaffney | Gaffney | South Carolina | 29340 | Recruiting |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | 29732 | Recruiting |
| Velocity Clinical Research, Spartanburg | Spartanburg | South Carolina | 29303 | Recruiting |
| Health Concepts | Rapid City | South Dakota | 57702 | Recruiting |
| Clinical Trials Center of Middle Tennessee, LLC | Franklin | Tennessee | 37067 | Recruiting |
| Premier Research Center, LLC | Hendersonville | Tennessee | 37075 | Recruiting |
| South Texas Medical Research Institute, Inc., DBA TTS Research | Boerne | Texas | 78006 | Recruiting |
| Ten20 Clinical Research | Carrollton | Texas | 75010 | Recruiting |
| Horizon Clinical Research Group | Cypress | Texas | 77429 | Recruiting |
| Alina Clinical Trials, LLC. | Dallas | Texas | 75209 | Recruiting |
| Greater Heights & Memorial Pulmonary and Sleep | Houston | Texas | 77008 | Recruiting |
| Houston Pulmonary Sleep and Allergy Associates | Houston | Texas | 77065 | Recruiting |
| Sherman Clinical Research | Sherman | Texas | 75090 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07363694, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 30, 2026 · Synced Sep 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07363694 live on ClinicalTrials.gov.