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Recruiting Phase 3 Interventional

A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT

ClinicalTrials.gov ID: NCT07387367

Public ClinicalTrials.gov record NCT07387367. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 1, 2026, 11:22 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Prospective, Randomized, Open-label Efficacy and Safety Study of Intravenous Brincidofovir Versus Intravenous Cidofovir for Treatment of Adenovirus Infection in Pediatric and Adult Subjects After Allogeneic Hematopoietic Cell Transplantation (Allo-HCT)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This randomized, open-label, parallel group, two-arm, multi-center assessment will compare IV BCV with IV CDV in adult and pediatric allogeneic HCT recipients with AdV viremia. A virologic response-driven approach to duration of treatment will be evaluated, in which randomized subjects are treated with either BCV or CDV until AdV viremia is confirmed as undetectable or until a maximum of 12 weeks of therapy, whichever occurs first. All subjects will be followed for a total of 24 weeks post-randomization, regardless of treatment assignment. Subjects will be assessed on a weekly basis through the end of treatment visit (EOT). Additional assessments will be performed at the test of cure (TOC) visit, which is 4 weeks after the last dose of study drug and at Weeks 12 and 24 post W1D1.

Study identification

NCT ID
NCT07387367
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
SymBio Pharmaceuticals
Industry
Enrollment
180 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
2 Months and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 16, 2026
Primary completion
Jan 30, 2028
Completion
Jun 29, 2028
Last update posted
Aug 9, 2026

2026 – 2028

United States locations

U.S. sites
32
U.S. states
22
U.S. cities
28
Facility City State ZIP Site status
Phoenix Children's Hospital Phoenix Arizona 85016 Recruiting
City of Hope Duarte California 91010 Recruiting
Stanford Medicine Children's Health Palo Alto California 94304 Not yet recruiting
University of California Davis Sacramento California 95616 Recruiting
Rady Children's Hospital San Diego California 92123 Not yet recruiting
Children's Hospital Colorado-Center for Cancer and Blood Disorders Aurora Colorado 80045 Not yet recruiting
Children's National Hospital Washington D.C. District of Columbia 20010 Recruiting
Johns Hopkins All Children's Hospital St. Petersburg Florida 33701 Not yet recruiting
Children's Healthcare of Atlanta Atlanta Georgia 30329 Recruiting
Ann and Robert H Lurie Children's Hospital Chicago Illinois 60611 Recruiting
University of Chicago Chicago Illinois 60637 Not yet recruiting
Riley Children's Health (Indiana University) Indianapolis Indiana 46202 Recruiting
Dana-Farber Cancer Institute-Brighman and Women's Boston Massachusetts 02115 Recruiting
Dana-Farber/Boston Children's Cancer and Blood Disorders Center Boston Massachusetts 02139 Recruiting
Helen Devos Children's Hospital / Michigan State University Grand Rapids Michigan 49503 Not yet recruiting
University of Minnesota Minneapolis Minnesota 55455 Not yet recruiting
St Louis Children's Hospital - Barnes Jewish Hospital St Louis Missouri 63110 Recruiting
University of Nebraska Omaha Nebraska 68182 Recruiting
Joseph M Sanzari Children's Hospital Hackensack New Jersey 07601 Recruiting
Cohen Children's Medical Center New Hyde Park New York 11042 Recruiting
Columbia University Irving Medical Center New York New York 10032 Not yet recruiting
Weill Cornell Medicine New York New York 10065 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Cincinnati Children's Hospital Cincinnati Ohio 45229 Recruiting
Nationwide Children's Hospital Columbus Ohio 43205 Not yet recruiting
Children's Hospital of Philadelphia Philadelphia Pennsylvania 19104 Recruiting
University of Pittsburgh Medical Center Children's Hospital Pittsburgh Pennsylvania 15213 Not yet recruiting
St. Jude Children's Research Hospital Memphis Tennessee 38105 Recruiting
UT Southwestern Medical Center Dallas Texas 75390 Not yet recruiting
Seattle Children's Hospital Seattle Washington 98105 Recruiting
Fred Hutchinson Cancer Center Seattle Washington 98109 Not yet recruiting
Medical College of Wisconsin / Children's Wisconsin Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07387367, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 9, 2026 · Synced Sep 1, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07387367 live on ClinicalTrials.gov.

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