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Recruiting Phase 3 Interventional

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

ClinicalTrials.gov ID: NCT07391657

Public ClinicalTrials.gov record NCT07391657. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Open-label, Randomised, Multicentre Study Comparing AZD0120, a Dual-Targeting Autologous Chimeric Antigen Receptor T-cell (CART) Therapy Directed Against BCMA and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma.

Study identification

NCT ID
NCT07391657
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
508 participants

Conditions and interventions

Interventions

  • AZD0120 Biological
  • Bortezomib Drug
  • Carfilzomib Drug
  • Daratumumab Drug
  • Dexamethasone Drug
  • Pomalidomide Drug

Biological · Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 22, 2026
Primary completion
Jun 13, 2028
Completion
Aug 11, 2030
Last update posted
Apr 29, 2026

2026 – 2030

United States locations

U.S. sites
43
U.S. states
25
U.S. cities
39
Facility City State ZIP Site status
Research Site Gilbert Arizona 85234 Not yet recruiting
Research Site Phoenix Arizona 85054 Not yet recruiting
Research Site Tucson Arizona 85719 Not yet recruiting
Research Site La Jolla California 92093 Withdrawn
Research Site Sacramento California 95817 Not yet recruiting
Research Site Santa Monica California 90404 Not yet recruiting
Research Site Denver Colorado 80218 Not yet recruiting
Research Site New Haven Connecticut 06510 Not yet recruiting
Research Site Washington D.C. District of Columbia 20007 Not yet recruiting
Research Site Coral Gables Florida 33156 Not yet recruiting
Research Site Atlanta Georgia 30322 Not yet recruiting
Research Site Chicago Illinois 60612 Not yet recruiting
Research Site Park Ridge Illinois 60068 Withdrawn
Research Site Iowa City Iowa 52242 Withdrawn
Research Site Kansas City Kansas 66160 Not yet recruiting
Research Site Louisville Kentucky 40207 Not yet recruiting
Research Site Boston Massachusetts 02114 Not yet recruiting
Research Site Boston Massachusetts 02215 Withdrawn
Research Site Detroit Michigan 48201 Withdrawn
Research Site Detroit Michigan 48202 Withdrawn
Research Site Rochester Minnesota 55905 Not yet recruiting
Research Site New York New York 10016 Withdrawn
Research Site New York New York 10029 Not yet recruiting
Research Site New York New York 10065 Not yet recruiting
Research Site Rochester New York 14642 Withdrawn
Research Site The Bronx New York 10467 Withdrawn
Research Site Chapel Hill North Carolina 27514 Not yet recruiting
Research Site Charlotte North Carolina 28204 Not yet recruiting
Research Site Winston-Salem North Carolina 27103 Not yet recruiting
Research Site Cincinnati Ohio 45220 Not yet recruiting
Research Site Cleveland Ohio 44195 Not yet recruiting
Research Site Portland Oregon 97239 Not yet recruiting
Research Site Charleston South Carolina 29425 Withdrawn
Research Site Nashville Tennessee 37203 Not yet recruiting
Research Site Austin Texas 78704 Not yet recruiting
Research Site Dallas Texas 75235 Not yet recruiting
Research Site Houston Texas 77030 Not yet recruiting
Research Site Salt Lake City Utah 84112 Not yet recruiting
Research Site Charlottesville Virginia 22908 Withdrawn
Research Site Richmond Virginia 23298 Withdrawn
Research Site Seattle Washington 98104 Not yet recruiting
Research Site Madison Wisconsin 53792 Not yet recruiting
Research Site Milwaukee Wisconsin 53226 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 67 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07391657, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 29, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07391657 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →