A Multicenter, Randomized, Double-Masked, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of ZOC2017217 in Subjects With Age-Related Cataract
Public ClinicalTrials.gov record NCT07395986. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, randomized, double-masked, placebo-controlled pilot study conducted in the United States (US) in subjects with age-related cataract in one or both eyes. Approximately 40 subjects with age-related cataract will be stratified by race and Best Corrected Distance Visual Acuity (BCDVA) and randomized (1:1) to active investigational product (IP) or placebo. Subjects will administer their assigned IP in both eyes, except as noted below, two times a day (BID) for 24 weeks before being exited from the study. Subjects with new or ongoing ocular adverse events (AEs) at the time of planned study exit will be asked to return 2 weeks later for a safety follow-up evaluation. The study eye will be the qualified eye that meets study eligibility criteria. Data from the study eye will be used for the purposes of efficacy analyses. Both eyes will receive treatment, except in subjects who have previously undergone cataract surgery in the non-study eye or whose non-study eye, in the opinion of the Investigator, is not suitable for treatment with the IP due to safety or another concern.
Study identification
- NCT ID
- NCT07395986
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 8 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 10, 2026 (Actual)
- Primary completion
- Feb 2027 (Estimated)
- Completion
- Feb 2027 (Estimated)
- Last update posted
- Aug 11, 2026
2026 – 2027
United States locations
- U.S. sites
- 21
- U.S. states
- 12
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cornea and Cataract Consultants of Arizona | Scottsdale | Arizona | 85255 | — |
| Catalina Eye | Tucson | Arizona | 85712 | — |
| Global Research Management | Glendale | California | 91204 | — |
| Inland Eye Specialists | Hemet | California | 92545 | — |
| United Medical Research Institute | Inglewood | California | 90301 | — |
| North Bay Eye Associates, Inc. | Petaluma | California | 94954 | — |
| East West Eye Institute - Torrance | Torrance | California | 90505 | — |
| ICON Eye Care | Grand Junction | Colorado | 81501 | — |
| Advanced Vision Research Institute | Longmont | Colorado | 80503 | — |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | — |
| Levenson Eye Associates | Jacksonville | Florida | 32204 | — |
| Clayton Eye Clinical Research, LLC | Morrow | Georgia | 30260 | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| Oculus Research - Cary | Cary | North Carolina | 27518 | — |
| Bergstrom Eye Research | Fargo | North Dakota | 58103 | — |
| Cincinnati Eye Institute - Blue Ash | Blue Ash | Ohio | 45242 | — |
| Verum Research | Eugene | Oregon | 97401 | — |
| Erie Retina Research | Erie | Pennsylvania | 16505 | — |
| Valley Retina Institute P.A. | Laredo | Texas | 78041 | — |
| Valley Retina Institute P.A. | McAllen | Texas | 78503 | — |
| R and R Eye Research, LLC | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07395986, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07395986 live on ClinicalTrials.gov.