AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
Public ClinicalTrials.gov record NCT07400107. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Overweight or Obesity, and Type 2 Diabetes (AMAZE 8)
Study identification
- NCT ID
- NCT07400107
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 1,000 participants
Conditions and interventions
Conditions
Interventions
- NNC0487-0111 Drug
- Placebo (matched to NNC0487-0111) Drug
- Placebo (matched to semaglutide) Drug
- Semaglutide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2026
- Primary completion
- Dec 11, 2028
- Completion
- Jan 25, 2029
- Last update posted
- Mar 11, 2026
2026 – 2029
United States locations
- U.S. sites
- 10
- U.S. states
- 7
- U.S. cities
- 10
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| Optimal Research Sites | Orange City | Florida | 32763 | — |
| Encore Medical Research of Weston | Weston | Florida | 33331 | — |
| Endocrine Research Solutions, Inc | Roswell | Georgia | 30076 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Endo And Metab Cons | Rockville | Maryland | 20852 | — |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098-6368 | — |
| Velocity Clin Res, Dallas | Dallas | Texas | 75230 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 110 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07400107, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 11, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07400107 live on ClinicalTrials.gov.