A Study of Brenipatide in Participants With Opioid Use Disorder

ClinicalTrials.gov ID: NCT07420283

Public ClinicalTrials.gov record NCT07420283. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:34 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study With a Separate Open-label Cohort to Evaluate the Efficacy and Safety of Brenipatide as Adjunctive Treatment to Transmucosal Buprenorphine With or Without Naloxone in Early Recovery of Participants With Opioid Use Disorder (RENEW-Op-1)

Study identification

NCT ID: NCT07420283
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 465 participants

Conditions and interventions

Conditions

Opioid Use Disorder

Interventions

Brenipatide Drug
Buprenorphine Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 12, 2026
Primary completion: Feb 29, 2028
Completion: Feb 29, 2028
Last update posted: Apr 22, 2026

2026 – 2028

United States locations

U.S. sites: 38
U.S. states: 19
U.S. cities: 33

Facility	City	State	ZIP	Site status
NoesisPharma - Phoenix - East Shea Boulevard	Phoenix	Arizona	85028	Recruiting
Pillar Clinical Research- Little Rock	Little Rock	Arkansas	72204	Not yet recruiting
Woodland International Research Group	Little Rock	Arkansas	72211	Recruiting
Ark Clinical Research - Fountain Valley	Fountain Valley	California	92708	Recruiting
Center on Substance Use and Health (CSUH)	San Francisco	California	94102	Not yet recruiting
UCSF Weill Institute for Neurosciences - Substance Use Disorders Clinic - Mission Bay	San Francisco	California	94158	Recruiting
Bradenton Research Center, Inc.	Bradenton	Florida	34205	Recruiting
K2 Medical Research - Daytona Beach	Daytona Beach	Florida	32114	Recruiting
NextPhase Research Florida - Hollywood	Hollywood	Florida	33024	Recruiting
Accel Research Sites - Lakeland Clinical Research Unit	Lakeland	Florida	33803	Recruiting
Life Arc Research Centers - Miami	Miami	Florida	33126	Recruiting
Advanced Research for Health Improvement, LLC	Naples	Florida	34102	Recruiting
Innovative Research Institute - Port Charlotte	Port Charlotte	Florida	33952	Not yet recruiting
Better Years Ahead Medical Center	Tampa	Florida	33614	Recruiting
Neuroscience Research Institute - West Palm Beach	West Palm Beach	Florida	33407	Recruiting
Re:Cognition Health - Chicago	Chicago	Illinois	60611	Recruiting
Indiana University Health Neuroscience Center	Indianapolis	Indiana	46202	Recruiting
University of Kentucky Chandler Medical Center	Lexington	Kentucky	40508	Not yet recruiting
Maryland Treatment Centers - Mountain Manor Treatment Center	Baltimore	Maryland	21229	Recruiting
Maryland Treatment Centers - Avery Road Treatment Center	Rockville	Maryland	20853	Not yet recruiting
Brigham and Women's Hospital	Boston	Massachusetts	02115	Not yet recruiting
Adams Clinical Boston	Boston	Massachusetts	02116	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Not yet recruiting
Adams Clinical Watertown	Watertown	Massachusetts	02472	Recruiting
SKY Integrative Medical Center/SKYCRNG	Ridgeland	Mississippi	39157	Recruiting
Adams Clinical Harlem	New York	New York	10029	Recruiting
Adams Clinical Bronx	The Bronx	New York	10461	Recruiting
Ohio Clinical Trials	Columbus	Ohio	43212	Recruiting
Rivus Wellness and Research Institute	Oklahoma City	Oklahoma	73112	Suspended
Adams Clinical Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Penn Medicine: University of Pennsylvania Health System	Philadelphia	Pennsylvania	19104	Not yet recruiting
Brown University School of Public Health	Providence	Rhode Island	02903	Recruiting
Avera Research Institute - Sioux Falls	Sioux Falls	South Dakota	57108	Recruiting
Adams Clinical Dallas	DeSoto	Texas	75115	Recruiting
Biopharma Informatic, LLC	Houston	Texas	77043	Recruiting
University of Virginia Health System	Charlottesville	Virginia	22903	Not yet recruiting
Carilion Clinic	Roanoke	Virginia	24014	Not yet recruiting
University of Washington - Harborview Medical Center	Seattle	Washington	98104	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07420283, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 22, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07420283 live on ClinicalTrials.gov.

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