Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Public ClinicalTrials.gov record NCT07421700. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL PHASE 1B/2, OPEN-LABEL STUDY TO INVESTIGATE THE SAFETY, ANTITUMOR ACTIVITY, AND PHARMACOKINETICS OF PF 08634404 MONOTHERAPY OR IN COMBINATION WITH ENFORTUMAB VEDOTIN IN ADULT PARTICIPANTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL CANCER
Study identification
- NCT ID
- NCT07421700
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 132 participants
Conditions and interventions
Interventions
- Enfortumab Vedotin Biological
- PF-08634404 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 10, 2026
- Primary completion
- Dec 5, 2027
- Completion
- Sep 4, 2028
- Last update posted
- Apr 19, 2026
2026 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 7
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Highlands Oncology Group, PA | Fayetteville | Arkansas | 72703 | Not yet recruiting |
| Highlands Oncology Group, PA | Rogers | Arkansas | 72758 | Not yet recruiting |
| Highlands Oncology Group, PA | Springdale | Arkansas | 72762 | Not yet recruiting |
| Rocky Mountain Cancer Centers, LLP | Aurora | Colorado | 80012 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Lone Tree | Colorado | 80124 | Recruiting |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | Not yet recruiting |
| New York Oncology Hematology | Albany | New York | 12206 | Not yet recruiting |
| New York Oncology Hematology | Clifton Park | New York | 12065 | Not yet recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology - Central/South Texas | Austin | Texas | 78705 | Recruiting |
| Texas Oncology - Austin | Austin | Texas | 78731 | Recruiting |
| Texas Oncology - Central/South Texas | Austin | Texas | 78731 | Recruiting |
| Texas Oncology - Central/South Texas | Austin | Texas | 78745 | Recruiting |
| Texas Oncology - Central South | Austin | Texas | 78758 | Recruiting |
| Texas Oncology - Central/South Texas | Austin | Texas | 78758 | Recruiting |
| Texas Oncology - Gulf Coast | Beaumont | Texas | 77702 | Recruiting |
| Texas Oncology - Central/South Texas | Harlingen | Texas | 78550 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77024 | Recruiting |
| Texas Oncology - Gulf Coast | Houston | Texas | 77054 | Recruiting |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | Not yet recruiting |
| Texas Oncology - Central/South Texas | McAllen | Texas | 78503 | Recruiting |
| Texas Oncology - Gulf Coast | Pearland | Texas | 77584 | Recruiting |
| Texas Oncology - Gulf Coast | Sugar Land | Texas | 77479 | Recruiting |
| Texas Oncology - Gulf Coast | The Woodlands | Texas | 77380 | Recruiting |
| Texas Oncology - Central/South Texas | Waco | Texas | 76712 | Recruiting |
| Texas Oncology - Gulf Coast | Webster | Texas | 77598 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Blacksburg | Virginia | 24060 | Recruiting |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Low Moor | Virginia | 24457 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Not yet recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Salem | Virginia | 24153 | Recruiting |
| Oncology & Hematology Associates of Southwest Virginia, Inc.,DBA Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07421700, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07421700 live on ClinicalTrials.gov.