A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)
Public ClinicalTrials.gov record NCT07425522. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I, Multicenter, Open-Label, Multiple-Ascending Dose Study of the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 Administered by Intravitreal Injection as Monotherapy and in Combination With Faricimab in Patients With Diabetic Macular Edema
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of multiple doses of RO7823653 in participants with DME, administered by intravitreal (IVT) injection as monotherapy and co-administered with faricimab.
Study identification
- NCT ID
- NCT07425522
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 93 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 20, 2026
- Primary completion
- Nov 16, 2028
- Completion
- Nov 16, 2028
- Last update posted
- Aug 13, 2026
2026 – 2028
United States locations
- U.S. sites
- 12
- U.S. states
- 8
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants - Peoria - DocTrials - PPDS | Peoria | Arizona | 85381-3690 | Recruiting |
| Retina-Vitreous Associates Medical Group | Beverly Hills | California | 90211-1838 | Recruiting |
| Bay Area Retina Specialists Medical Group - Vestrum - PPDS | Walnut Creek | California | 94598-5915 | Recruiting |
| Retina Vitreous Associates of Florida | St. Petersburg | Florida | 33711-1141 | Recruiting |
| Wilmer Eye Institute | Baltimore | Maryland | 21287-0005 | Recruiting |
| Erie Retina Research, LLC - 300 State St | Erie | Pennsylvania | 16507-1429 | Recruiting |
| Wills Eye Hospital | Philadelphia | Pennsylvania | 19107-5109 | Recruiting |
| Charles Retina Institute | Germantown | Tennessee | 38138-2405 | Recruiting |
| Retina Research Institute of Texas | Abilene | Texas | 79606-1224 | Recruiting |
| Austin Clinical Research, LLC | Austin | Texas | 78750-2298 | Recruiting |
| Retina Consultants of Texas Westover Hills Retina Center | San Antonio | Texas | 78251 | Recruiting |
| Piedmont Eye Center | Lynchburg | Virginia | 24502-4271 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07425522, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 13, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07425522 live on ClinicalTrials.gov.