A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults
Public ClinicalTrials.gov record NCT07425574. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Observational Study of Natural Disease Progression in Participants With Macular Dystrophies Expressing a Stargardt-type Clinical Presentation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Macular dystrophies are a group of inherited eye conditions that affect the macula. The macula is in the center of the retina, the light sensitive part at the back of the eye. In people with macular dystrophies, some of the cells in the macula gradually stop working and may die over time. This leads to vision loss in the center of the eye. Side vision (peripheral vision) is mostly unaffected. Stargardt disease (STGD) is a type of macular dystrophy which is caused by 1 faulty gene (ABCA4). Vision loss most typically happens in childhood, but many people do not develop it until they are adults. As well as STGD, there are other macular dystrophies that look very similar to STGD but that are caused by many other different genes. Together, STGD and STGD-like conditions can be called STGD-type macular dystrophies. This is because they look the same clinically and have similar symptoms. Since different genes can cause these conditions, genetic testing is the only way to be sure which specific condition a person has. In this study, researchers want to learn if the disease progresses in a similar way in people with STGD and STGD-like macular dystrophies. People taking part in the study will continue to manage their condition, as agreed with their own doctor. People will visit their clinic every 6 months to have various standard eye tests and imaging. The information collected will include questions about people's wellbeing, general health, medication and supplements taken, and daily activities. Children over 6 years old and adults with STGD-type macular dystrophies may take part in this study. They will be in the study for up to 24 months (2 years). The study sponsor (Astellas) will not decide how people's condition is managed. However, the sponsor will provide instructions on when people visit their clinic and what is recorded during the study. If available, medical records, clinical and imaging data from previous visits going back 24 months will also be reviewed.
Study identification
- NCT ID
- NCT07425574
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 90 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 6 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 19, 2026
- Primary completion
- Jul 30, 2028
- Completion
- Jul 30, 2028
- Last update posted
- Aug 24, 2026
2026 – 2028
United States locations
- U.S. sites
- 15
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants | Phoenix | Arizona | 85020 | Recruiting |
| Stanford University School of Medicine | Palo Alto | California | 94303 | Recruiting |
| University of California Health - UC Davis | Sacramento | California | 95817 | Recruiting |
| University of Florida Health - UF Health Jacksonville | Jacksonville | Florida | 32209 | Recruiting |
| University of Miami Health System - Bascom Palmer Eye Institute | Miami | Florida | 33136 | Recruiting |
| University of Illinois Chicago - UI Health | Chicago | Illinois | 60612 | Recruiting |
| University of Michigan Health - Kellogg Eye Center | Ann Arbor | Michigan | 48105 | Recruiting |
| Deep Blue Retina | Southaven | Mississippi | 38671 | Recruiting |
| Duke Eye Center | Durham | North Carolina | 27710 | Recruiting |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | Recruiting |
| Casey Eye Institute - Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| Wills Eye Physicians - Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | Recruiting |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | Recruiting |
| University of Utah Health - John A Moran Eye Center | Salt Lake City | Utah | 84312 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07425574, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07425574 live on ClinicalTrials.gov.