ClinicalTrials.gov record
Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
ClinicalTrials.gov ID: NCT07431281
Public ClinicalTrials.gov record NCT07431281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in First-Line Claudin18.2-Positive, HER2-Negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)
Study identification
- NCT ID
- NCT07431281
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,130 participants
Conditions and interventions
Interventions
- 5-Fluorouracil Drug
- Capecitabine Drug
- Leucovorin Drug
- Nivolumab Drug
- Oxaliplatin Drug
- Rilvegostomig Drug
- Sonesitatug vedotin Drug
- Zolbetuximab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 2, 2026
- Primary completion
- Aug 15, 2029
- Completion
- Oct 26, 2031
- Last update posted
- Apr 12, 2026
2026 – 2031
United States locations
- U.S. sites
- 69
- U.S. states
- 30
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Phoenix | Arizona | 85054 | Not yet recruiting |
| Research Site | Springdale | Arkansas | 72762 | Not yet recruiting |
| Research Site | Duarte | California | 91010 | Not yet recruiting |
| Research Site | La Jolla | California | 92093 | Not yet recruiting |
| Research Site | Los Alamitos | California | 90720 | Not yet recruiting |
| Research Site | Orange | California | 92868 | Not yet recruiting |
| Research Site | Walnut Creek | California | 94598 | Not yet recruiting |
| Research Site | Denver | Colorado | 80210 | Not yet recruiting |
| Research Site | Lone Tree | Colorado | 80124 | Not yet recruiting |
| Research Site | New Haven | Connecticut | 06510 | Withdrawn |
| Research Site | Newark | Delaware | 19713 | Not yet recruiting |
| Research Site | Washington D.C. | District of Columbia | 20007 | Withdrawn |
| Research Site | Fort Myers | Florida | 33901 | Withdrawn |
| Research Site | Jacksonville | Florida | 32224 | Not yet recruiting |
| Research Site | St. Petersburg | Florida | 33705 | Withdrawn |
| Research Site | West Palm Beach | Florida | 33401 | Withdrawn |
| Research Site | Atlanta | Georgia | 30309 | Not yet recruiting |
| Research Site | Atlanta | Georgia | 30322 | Not yet recruiting |
| Research Site | Atlanta | Georgia | 30342 | Withdrawn |
| Research Site | Macon | Georgia | 31201 | Not yet recruiting |
| Research Site | Newnan | Georgia | 30265 | Not yet recruiting |
| Research Site | Chicago | Illinois | 60637 | Not yet recruiting |
| Research Site | Niles | Illinois | 60714 | Not yet recruiting |
| Research Site | Zion | Illinois | 60099 | Not yet recruiting |
| Research Site | Indianapolis | Indiana | 46260 | Not yet recruiting |
| Research Site | Waukee | Iowa | 50263 | Not yet recruiting |
| Research Site | Lexington | Kentucky | 40536 | Not yet recruiting |
| Research Site | Louisville | Kentucky | 40207 | Not yet recruiting |
| Research Site | Boston | Massachusetts | 02114 | Not yet recruiting |
| Research Site | Burlington | Massachusetts | 01803 | Not yet recruiting |
| Research Site | Grand Rapids | Michigan | 49503 | Recruiting |
| Research Site | Burnsville | Minnesota | 55337 | Not yet recruiting |
| Research Site | Rochester | Minnesota | 55905 | Not yet recruiting |
| Research Site | Kansas City | Missouri | 64132 | Not yet recruiting |
| Research Site | St Louis | Missouri | 63110 | Not yet recruiting |
| Research Site | Camden | New Jersey | 08103 | Not yet recruiting |
| Research Site | East Brunswick | New Jersey | 08816 | Recruiting |
| Research Site | Hackensack | New Jersey | 07601 | Not yet recruiting |
| Research Site | Summit | New Jersey | 07901 | Not yet recruiting |
| Research Site | New York | New York | 10029 | Withdrawn |
| Research Site | New York | New York | 10032 | Not yet recruiting |
| Research Site | New York | New York | 10065 | Not yet recruiting |
| Research Site | The Bronx | New York | 10461 | Not yet recruiting |
| Research Site | The Bronx | New York | 10468 | Not yet recruiting |
| Research Site | White Plains | New York | 10601 | Withdrawn |
| Research Site | Winston-Salem | North Carolina | 27103 | Not yet recruiting |
| Research Site | Cleveland | Ohio | 44195 | Withdrawn |
| Research Site | Columbus | Ohio | 43221 | Not yet recruiting |
| Research Site | Portland | Oregon | 97213 | Not yet recruiting |
| Research Site | Portland | Oregon | 97239 | Not yet recruiting |
| Research Site | Hershey | Pennsylvania | 17033 | Not yet recruiting |
| Research Site | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| Research Site | Pittsburgh | Pennsylvania | 15232 | Not yet recruiting |
| Research Site | Pittsburgh | Pennsylvania | 15240 | Not yet recruiting |
| Research Site | Wilkes-Barre | Pennsylvania | 18711 | Not yet recruiting |
| Research Site | Sioux Falls | South Dakota | 57105 | Not yet recruiting |
| Research Site | Memphis | Tennessee | 38104 | Withdrawn |
| Research Site | Nashville | Tennessee | 37203 | Recruiting |
| Research Site | Dallas | Texas | 75246 | Not yet recruiting |
| Research Site | Sherman | Texas | 75090 | Not yet recruiting |
| Research Site | Blacksburg | Virginia | 24060 | Not yet recruiting |
| Research Site | Fairfax | Virginia | 22031 | Not yet recruiting |
| Research Site | Falls Church | Virginia | 22042 | Withdrawn |
| Research Site | Fort Belvoir | Virginia | 22060 | Not yet recruiting |
| Research Site | Richmond | Virginia | 23219 | Not yet recruiting |
| Research Site | Olympia | Washington | 98502 | Not yet recruiting |
| Research Site | Seattle | Washington | 98104 | Not yet recruiting |
| Research Site | Charleston | West Virginia | 25315 | Not yet recruiting |
| Research Site | Milwaukee | Wisconsin | 53226 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 189 non-U.S. sites.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07431281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced May 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07431281 live on ClinicalTrials.gov.