Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

ClinicalTrials.gov ID: NCT07431281

Public ClinicalTrials.gov record NCT07431281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Oct 17, 2026, 2:49 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in First-Line Claudin18.2-Positive, HER2-Negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in first-line (1L) Claudin18.2 (CLDN18.2)-positive, human epidermal growth factor receptor 2 (HER2)-negative, gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.

Study identification

NCT ID
NCT07431281
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
2,130 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 3, 2026 (Actual)
Primary completion
Aug 16, 2029 (Estimated)
Completion
Oct 27, 2031 (Estimated)
Last update posted
Oct 16, 2026

2026 – 2031

United States locations

U.S. sites
93
U.S. states
35
U.S. cities
84
Facility City State ZIP Site status
Research Site Birmingham Alabama 35294-3300 Not yet recruiting
Research Site Mobile Alabama 36604 Not yet recruiting
Research Site Anchorage Alaska 99508 Not yet recruiting
Research Site Phoenix Arizona 85054 Recruiting
Research Site Springdale Arkansas 72762 Not yet recruiting
Research Site Duarte California 91010 Not yet recruiting
Research Site Fountain Valley California 92708 Recruiting
Research Site Fullerton California 92835 Not yet recruiting
Research Site Irvine California 92612 Recruiting
Research Site La Jolla California 92093 Recruiting
Research Site Los Alamitos California 90720 Not yet recruiting
Research Site Orange California 92868 Recruiting
Research Site Walnut Creek California 94598 Recruiting
Research Site Whittier California 90602 Not yet recruiting
Research Site Denver Colorado 80210 Not yet recruiting
Research Site Lone Tree Colorado 80124 Recruiting
Research Site New Haven Connecticut 06510 Withdrawn
Research Site Newark Delaware 19713 Not yet recruiting
Research Site Washington D.C. District of Columbia 20007 Withdrawn
Research Site Fort Myers Florida 33901 Withdrawn
Research Site Jacksonville Florida 32207 Not yet recruiting
Research Site Jacksonville Florida 32224 Recruiting
Research Site Orlando Florida 32806 Not yet recruiting
Research Site St. Petersburg Florida 33705 Withdrawn
Research Site West Palm Beach Florida 33401 Withdrawn
Research Site Atlanta Georgia 30309 Recruiting
Research Site Atlanta Georgia 30322 Recruiting
Research Site Atlanta Georgia 30342 Withdrawn
Research Site Macon Georgia 31201 Recruiting
Research Site Newnan Georgia 30265 Not yet recruiting
Research Site Chicago Illinois 60637 Not yet recruiting
Research Site Niles Illinois 60714 Recruiting
Research Site Zion Illinois 60099 Not yet recruiting
Research Site Indianapolis Indiana 46260 Recruiting
Research Site Waukee Iowa 50263 Not yet recruiting
Research Site Lexington Kentucky 40536 Not yet recruiting
Research Site Louisville Kentucky 40217 Not yet recruiting
Research Site Silver Spring Maryland 20910 Not yet recruiting
Research Site Boston Massachusetts 02114 Not yet recruiting
Research Site Burlington Massachusetts 01803 Not yet recruiting
Research Site Worcester Massachusetts 01655 Withdrawn
Research Site Grand Rapids Michigan 49503 Recruiting
Research Site Burnsville Minnesota 55337 Recruiting
Research Site Duluth Minnesota 55805 Not yet recruiting
Research Site Minneapolis Minnesota 55455 Not yet recruiting
Research Site Rochester Minnesota 55905 Recruiting
Research Site Kansas City Missouri 64132 Recruiting
Research Site St Louis Missouri 63110 Recruiting
Research Site Camden New Jersey 08103 Not yet recruiting
Research Site East Brunswick New Jersey 08816 Recruiting
Research Site Hackensack New Jersey 07601 Not yet recruiting
Research Site New Brunswick New Jersey 08901 Not yet recruiting
Research Site Summit New Jersey 07901 Recruiting
Research Site New York New York 10029 Withdrawn
Research Site New York New York 10032 Not yet recruiting
Research Site New York New York 10065 Recruiting
Research Site The Bronx New York 10461 Not yet recruiting
Research Site The Bronx New York 10468 Recruiting
Research Site White Plains New York 10601 Withdrawn
Research Site Charlotte North Carolina 28204 Recruiting
Research Site Wilmington North Carolina 28403 Recruiting
Research Site Winston-Salem North Carolina 27103 Recruiting
Research Site Cleveland Ohio 44195 Withdrawn
Research Site Columbus Ohio 43221 Not yet recruiting
Research Site Portland Oregon 97213 Recruiting
Research Site Portland Oregon 97239 Not yet recruiting
Research Site Hershey Pennsylvania 17033 Not yet recruiting
Research Site Philadelphia Pennsylvania 19104 Recruiting
Research Site Pittsburgh Pennsylvania 15232 Recruiting
Research Site Pittsburgh Pennsylvania 15240 Not yet recruiting
Research Site Wilkes-Barre Pennsylvania 18711 Recruiting
Research Site York Pennsylvania 17403 Recruiting
Research Site Providence Rhode Island 02903 Not yet recruiting
Research Site Charleston South Carolina 29425 Not yet recruiting
Research Site Sioux Falls South Dakota 57105 Recruiting
Research Site Yankton South Dakota 57078 Recruiting
Research Site Memphis Tennessee 38104 Withdrawn
Research Site Nashville Tennessee 37203 Recruiting
Research Site Dallas Texas 75235 Not yet recruiting
Research Site Dallas Texas 75246 Recruiting
Research Site Houston Texas 77030 Not yet recruiting
Research Site Sherman Texas 75090 Recruiting
Research Site Blacksburg Virginia 24060 Recruiting
Research Site Fairfax Virginia 22031 Recruiting
Research Site Falls Church Virginia 22042 Withdrawn
Research Site Fort Belvoir Virginia 22060 Not yet recruiting
Research Site Richmond Virginia 23219 Recruiting
Research Site Edmonds Washington 98026 Recruiting
Research Site Issaquah Washington 98029 Recruiting
Research Site Olympia Washington 98502 Not yet recruiting
Research Site Seattle Washington 98104 Recruiting
Research Site Charleston West Virginia 25304 Not yet recruiting
Research Site Milwaukee Wisconsin 53226 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 220 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07431281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 16, 2026 · Synced Oct 17, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07431281 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →