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Recruiting Phase 3 Interventional

Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

ClinicalTrials.gov ID: NCT07431281

Public ClinicalTrials.gov record NCT07431281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:54 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III, Multicentre, Randomised Controlled Study of Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in First-Line Claudin18.2-Positive, HER2-Negative, Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (CLARITY-Gastric 02)

Study identification

NCT ID
NCT07431281
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
2,130 participants

Conditions and interventions

Interventions

  • 5-Fluorouracil Drug
  • Capecitabine Drug
  • Leucovorin Drug
  • Nivolumab Drug
  • Oxaliplatin Drug
  • Rilvegostomig Drug
  • Sonesitatug vedotin Drug
  • Zolbetuximab Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 2, 2026
Primary completion
Aug 15, 2029
Completion
Oct 26, 2031
Last update posted
Apr 12, 2026

2026 – 2031

United States locations

U.S. sites
69
U.S. states
30
U.S. cities
62
Facility City State ZIP Site status
Research Site Phoenix Arizona 85054 Not yet recruiting
Research Site Springdale Arkansas 72762 Not yet recruiting
Research Site Duarte California 91010 Not yet recruiting
Research Site La Jolla California 92093 Not yet recruiting
Research Site Los Alamitos California 90720 Not yet recruiting
Research Site Orange California 92868 Not yet recruiting
Research Site Walnut Creek California 94598 Not yet recruiting
Research Site Denver Colorado 80210 Not yet recruiting
Research Site Lone Tree Colorado 80124 Not yet recruiting
Research Site New Haven Connecticut 06510 Withdrawn
Research Site Newark Delaware 19713 Not yet recruiting
Research Site Washington D.C. District of Columbia 20007 Withdrawn
Research Site Fort Myers Florida 33901 Withdrawn
Research Site Jacksonville Florida 32224 Not yet recruiting
Research Site St. Petersburg Florida 33705 Withdrawn
Research Site West Palm Beach Florida 33401 Withdrawn
Research Site Atlanta Georgia 30309 Not yet recruiting
Research Site Atlanta Georgia 30322 Not yet recruiting
Research Site Atlanta Georgia 30342 Withdrawn
Research Site Macon Georgia 31201 Not yet recruiting
Research Site Newnan Georgia 30265 Not yet recruiting
Research Site Chicago Illinois 60637 Not yet recruiting
Research Site Niles Illinois 60714 Not yet recruiting
Research Site Zion Illinois 60099 Not yet recruiting
Research Site Indianapolis Indiana 46260 Not yet recruiting
Research Site Waukee Iowa 50263 Not yet recruiting
Research Site Lexington Kentucky 40536 Not yet recruiting
Research Site Louisville Kentucky 40207 Not yet recruiting
Research Site Boston Massachusetts 02114 Not yet recruiting
Research Site Burlington Massachusetts 01803 Not yet recruiting
Research Site Grand Rapids Michigan 49503 Recruiting
Research Site Burnsville Minnesota 55337 Not yet recruiting
Research Site Rochester Minnesota 55905 Not yet recruiting
Research Site Kansas City Missouri 64132 Not yet recruiting
Research Site St Louis Missouri 63110 Not yet recruiting
Research Site Camden New Jersey 08103 Not yet recruiting
Research Site East Brunswick New Jersey 08816 Recruiting
Research Site Hackensack New Jersey 07601 Not yet recruiting
Research Site Summit New Jersey 07901 Not yet recruiting
Research Site New York New York 10029 Withdrawn
Research Site New York New York 10032 Not yet recruiting
Research Site New York New York 10065 Not yet recruiting
Research Site The Bronx New York 10461 Not yet recruiting
Research Site The Bronx New York 10468 Not yet recruiting
Research Site White Plains New York 10601 Withdrawn
Research Site Winston-Salem North Carolina 27103 Not yet recruiting
Research Site Cleveland Ohio 44195 Withdrawn
Research Site Columbus Ohio 43221 Not yet recruiting
Research Site Portland Oregon 97213 Not yet recruiting
Research Site Portland Oregon 97239 Not yet recruiting
Research Site Hershey Pennsylvania 17033 Not yet recruiting
Research Site Philadelphia Pennsylvania 19104 Not yet recruiting
Research Site Pittsburgh Pennsylvania 15232 Not yet recruiting
Research Site Pittsburgh Pennsylvania 15240 Not yet recruiting
Research Site Wilkes-Barre Pennsylvania 18711 Not yet recruiting
Research Site Sioux Falls South Dakota 57105 Not yet recruiting
Research Site Memphis Tennessee 38104 Withdrawn
Research Site Nashville Tennessee 37203 Recruiting
Research Site Dallas Texas 75246 Not yet recruiting
Research Site Sherman Texas 75090 Not yet recruiting
Research Site Blacksburg Virginia 24060 Not yet recruiting
Research Site Fairfax Virginia 22031 Not yet recruiting
Research Site Falls Church Virginia 22042 Withdrawn
Research Site Fort Belvoir Virginia 22060 Not yet recruiting
Research Site Richmond Virginia 23219 Not yet recruiting
Research Site Olympia Washington 98502 Not yet recruiting
Research Site Seattle Washington 98104 Not yet recruiting
Research Site Charleston West Virginia 25315 Not yet recruiting
Research Site Milwaukee Wisconsin 53226 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 189 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07431281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 12, 2026 · Synced May 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07431281 live on ClinicalTrials.gov.

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