A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Public ClinicalTrials.gov record NCT07440225. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Study identification
- NCT ID
- NCT07440225
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 960 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 26, 2026
- Primary completion
- Jun 29, 2028
- Completion
- Jun 29, 2028
- Last update posted
- Sep 1, 2026
2026 – 2028
United States locations
- U.S. sites
- 64
- U.S. states
- 26
- U.S. cities
- 59
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Network Arizona / Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | Recruiting |
| Retina Center of Arkansas | Fayetteville | Arkansas | 72703 | Recruiting |
| Retina Partners of Northwest Arkansas, PLLC | Springdale | Arkansas | 72764 | Recruiting |
| Global Research Management, Inc. | Glendale | California | 91204 | Recruiting |
| Retinal Consultants Medical Group (Site 024) | Modesto | California | 95356 | Recruiting |
| Retina Consultants of Southern California (Site 043) | Redlands | California | 92374 | Recruiting |
| Retinal Consultants Medical Group (Site 020) | Sacramento | California | 95825 | Recruiting |
| Retinal Consultants Medical Group (Site 022) | Sacramento | California | 95841 | Recruiting |
| Florida Eye Clinic (Site 130) | Altamonte Springs | Florida | 32701 | Recruiting |
| Retina Group of Florida (Site 070) | Fort Lauderdale | Florida | 33308 | Recruiting |
| Vitreo Retinal Associates | Gainesville | Florida | 32607 | Recruiting |
| Florida Retina Institute | Jacksonville | Florida | 32216 | Recruiting |
| Florida Retina Consultants | Lakeland | Florida | 33805 | Recruiting |
| Retina Care Specialists | Palm Beach Gardens | Florida | 33410 | Recruiting |
| Fort Lauderdale Eye Institute (Site 042) | Plantation | Florida | 33324 | Recruiting |
| Retina Vitreous Associates of Florida (Site 049) | St. Petersburg | Florida | 33711 | Recruiting |
| Southern Vitreoretinal Associates | Tallahassee | Florida | 32308 | Recruiting |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | Recruiting |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33617 | Recruiting |
| Wildwood Clinical Research / Florida Retina Institute | Wildwood | Florida | 34785 | Recruiting |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62703 | Recruiting |
| Associated Vitreoretinal and Uveitis Consultants | Carmel | Indiana | 46032 | Recruiting |
| Midwest Eye Institute | Carmel | Indiana | 46032 | Recruiting |
| Cumberland Valley Retina Consultants (Site 007) | Hagerstown | Maryland | 21740 | Recruiting |
| Foundation for Vision Research (Site 073) | Grand Rapids | Michigan | 49546 | Recruiting |
| Retina Consultants of Minnesota | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Retina Specialists of Mississippi | Hattiesburg | Mississippi | 39402 | Recruiting |
| Mississippi Retina Associates (Site 084) | Madison | Mississippi | 39110 | Recruiting |
| Mid Atlantic Retina | Cherry Hill | New Jersey | 08034 | Recruiting |
| Vision Research Center Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | Recruiting |
| ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105) | Hauppauge | New York | 11788 | Recruiting |
| Retina Vitreous Surgeons of CNY, PC (Site 033) | Liverpool | New York | 13088 | Recruiting |
| Piedmont Retina Specialists - Greensboro | Greensboro | North Carolina | 27401 | Recruiting |
| North Carolina Retina Associates | Greenville | North Carolina | 27834 | Recruiting |
| Piedmont Retina Specialists - Winston-Salem | Winston-Salem | North Carolina | 27103 | Recruiting |
| Cincinnati Eye Institute (Site 133) | Cincinnati | Ohio | 45242 | Recruiting |
| Retina Vitreous Center | Edmond | Oklahoma | 73013 | Recruiting |
| Tulsa Retina Consultants | Tulsa | Oklahoma | 74114 | Recruiting |
| Retina Northwest, PC | Portland | Oregon | 97221 | Recruiting |
| EyeHealth Northwest | Portland | Oregon | 97225 | Recruiting |
| Mid Atlantic Retina (Site 050) | Bethlehem | Pennsylvania | 18017 | Recruiting |
| Palmetto Retina Center | Aiken | South Carolina | 29803 | Recruiting |
| Charleston Neuroscience Institute - Bluffton (Site 124) | Bluffton | South Carolina | 29910 | Recruiting |
| Charleston Neuroscience Institute (Site 104) | Charleston | South Carolina | 29414 | Recruiting |
| Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina | Mt. Pleasant | South Carolina | 29464 | Recruiting |
| Charles Retina Institute | Germantown | Tennessee | 38138 | Recruiting |
| Retina Research Institute of Texas (Site 010) | Abilene | Texas | 79606 | Recruiting |
| Southwest Retina Specialists | Amarillo | Texas | 79106 | Recruiting |
| Texas Retina Associates | Arlington | Texas | 76012 | Recruiting |
| Austin Research Center for Retina | Austin | Texas | 78705 | Recruiting |
| Austin Retina Associates (Site 012) | Austin | Texas | 78705 | Recruiting |
| Retina & Vitreous of Texas | Bellaire | Texas | 77401 | Recruiting |
| Texas Retina Associates | Dallas | Texas | 75231 | Recruiting |
| Texas Retina (Site 037) | Plano | Texas | 75075 | Recruiting |
| Retina Center of Texas | Southlake | Texas | 76092 | Recruiting |
| Retina Consultants of Texas (Site 014) | The Woodlands | Texas | 77384 | Recruiting |
| Strategic Clinical Research Group | Weatherford | Texas | 76087 | Recruiting |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | Recruiting |
| Piedmont Eye Center (Site 054) | Lynchburg | Virginia | 24502 | Recruiting |
| Pacific Northwest Retina (Site 112) | Burlington | Washington | 98233 | Recruiting |
| Spokane Eye Clinical Research (Site 075) | Spokane | Washington | 99204 | Recruiting |
| Retina Consultants, PLLC | Charleston | West Virginia | 25301 | Recruiting |
| Eye Clinic of Wisconsin | Wausau | Wisconsin | 54403 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 53 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07440225, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 1, 2026 · Synced Sep 4, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07440225 live on ClinicalTrials.gov.