A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Public ClinicalTrials.gov record NCT07440225. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Study identification
- NCT ID
- NCT07440225
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- EyeBiotech Ltd.
- Industry
- Enrollment
- 960 participants
Conditions and interventions
Conditions
Interventions
- Aflibercept Drug
- Tiespectus Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 26, 2026
- Primary completion
- Jun 29, 2028
- Completion
- Jun 29, 2028
- Last update posted
- May 3, 2026
2026 – 2028
United States locations
- U.S. sites
- 30
- U.S. states
- 15
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Partners of Northwest Arkansas, PLLC | Springdale | Arkansas | 72764 | Recruiting |
| Global Research Management, Inc. | Glendale | California | 91204 | Recruiting |
| Retinal Consultants Medical Group (Site 024) | Modesto | California | 95356 | Recruiting |
| Retina Consultants of Southern California (Site 043) | Redlands | California | 92374 | Recruiting |
| Retinal Consultants Medical Group (Site 020) | Sacramento | California | 95825 | Recruiting |
| Retinal Consultants Medical Group (Site 022) | Sacramento | California | 95841 | Recruiting |
| Retina Group of Florida (Site 070) | Fort Lauderdale | Florida | 33308 | Recruiting |
| Fort Lauderdale Eye Institute (Site 042) | Plantation | Florida | 33324 | Recruiting |
| Retina Vitreous Associates of Florida (Site 049) | St. Petersburg | Florida | 33711 | Recruiting |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | Recruiting |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33617 | Recruiting |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | Recruiting |
| Cumberland Valley Retina Consultants (Site 007) | Hagerstown | Maryland | 21740 | Recruiting |
| Foundation for Vision Research (Site 073) | Grand Rapids | Michigan | 49546 | Recruiting |
| Mississippi Retina Associates (Site 084) | Madison | Mississippi | 39110 | Recruiting |
| ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105) | Hauppauge | New York | 11788 | Recruiting |
| Retina Vitreous Surgeons of CNY, PC (Site 033) | Liverpool | New York | 13088 | Recruiting |
| Tulsa Retina Consultants | Tulsa | Oklahoma | 74114 | Recruiting |
| EyeHealth Northwest | Portland | Oregon | 97225 | Recruiting |
| Palmetto Retina Center | Aiken | South Carolina | 29803 | Recruiting |
| Charleston Neuroscience Institute - Bluffton (Site 124) | Bluffton | South Carolina | 29910 | Recruiting |
| Charleston Neuroscience Institute (Site 104) | Charleston | South Carolina | 29414 | Recruiting |
| Retina Research Institute of Texas (Site 010) | Abilene | Texas | 79606 | Recruiting |
| Austin Research Center for Retina | Austin | Texas | 78705 | Recruiting |
| Austin Retina Associates (Site 012) | Austin | Texas | 78705 | Recruiting |
| Texas Retina (Site 037) | Plano | Texas | 75075 | Recruiting |
| Retina Consultants of Texas (Site 014) | The Woodlands | Texas | 77384 | Recruiting |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | Recruiting |
| Piedmont Eye Center (Site 054) | Lynchburg | Virginia | 24502 | Recruiting |
| Pacific Northwest Retina (Site 112) | Burlington | Washington | 98233 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07440225, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07440225 live on ClinicalTrials.gov.