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Recruiting Phase 2 Interventional

A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events

ClinicalTrials.gov ID: NCT07448038

Public ClinicalTrials.gov record NCT07448038. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 7, 2026, 7:20 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase IIa, Multicenter, Randomized, Double-blind, Placebo-controlled Study of the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Selnoflast in Reducing Vascular Inflammation in Patients With Atherosclerosis at Risk for Major Adverse Cardiac Events

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The main purpose of the study is to evaluate the efficacy of selnoflast compared with placebo in participants with atherosclerosis, at high-risk for major adverse cardiovascular event (MACE), who are currently on standard-of-care (SOC) therapy.

Study identification

NCT ID
NCT07448038
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Genentech, Inc.
Industry
Enrollment
162 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 4, 2026
Primary completion
Jan 30, 2028
Completion
Feb 27, 2028
Last update posted
Sep 2, 2026

2026 – 2028

United States locations

U.S. sites
23
U.S. states
14
U.S. cities
21
Facility City State ZIP Site status
Cardiovascular Research Foundation of Southern California Beverly Hills California 90210 Recruiting
National Heart Institute Beverly Hills California 90211 Recruiting
Amnova Clinical Research Irvine California 92604 Recruiting
NorthBay Clinical Research Santa Rosa California 95405 Recruiting
Alliance Clinical West Hills (Focus Clinical Research) West Hills California 91307 Recruiting
Yale University School of Medicine Yale-New Haven Hospital (YNHH) - Smilow Cancer Hospital New Haven Connecticut 06520-8040 Recruiting
Inpatient Research Clinic (Las Palmas Medical Research Center) Miami Lakes Florida 33014 Recruiting
Asha Clinical Research-Munster,Llc Hammond Indiana 46324 Recruiting
Profound Research LLC at Cardiology and Vascular Associates - CAVA Bloomfield Hills Michigan 48304 Recruiting
Profound Research LLC at Millenium Cardiology Farmington Hills Michigan 48334 Recruiting
Ahmed Arif Medical Research Center (AA MRC LLC ) Flint Michigan 48504 Recruiting
University of Minnesota Minneapolis Minnesota 55455 Recruiting
Washington University, School of Medicine St Louis Missouri 63110 Recruiting
University of Nebraska Medical Center Omaha Nebraska 69198-4130 Recruiting
DiGiovanna Inst for Med Ed&Res North Massapequa New York 11758-1802 Recruiting
UNC Heart & Vascular Chapel Hill North Carolina 27599-7075 Recruiting
Preferred Primary Care Physicians, Inc Pittsburgh Pennsylvania 15243 Recruiting
Vanderbilt University School of Medicine (VUSM) - Vanderbilt Translational and Clinical Cardiovascular Research Center (VTRACC) Nashville Tennessee 37203 Recruiting
Southwest Family Medicine Associates Dallas Texas 75235 Recruiting
East Texas Cardiology PA Houston Texas 77002 Recruiting
Cardiovascular Specialists of Willowbrook Houston Texas 77070 Recruiting
UT Health San Antonio San Antonio Texas 78229 Recruiting
Eastside Research Associates, LLC dba Era Health Research Redmond Washington 98036 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07448038, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 2, 2026 · Synced Sep 7, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07448038 live on ClinicalTrials.gov.

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