CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

ClinicalTrials.gov ID: NCT07449923

Public ClinicalTrials.gov record NCT07449923. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:08 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)

Study identification

NCT ID: NCT07449923
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: EyePoint Pharmaceuticals, Inc.; Industry
Enrollment: 240 participants

Conditions and interventions

Conditions

Interventions

Aflibercept (2.0 mg) Drug
EYP-1901 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 8, 2026
Primary completion: Sep 30, 2027
Completion: Sep 30, 2028
Last update posted: May 5, 2026

2026 – 2028

United States locations

U.S. sites: 48
U.S. states: 22
U.S. cities: 45

Facility	City	State	ZIP	Site status
Associated Retina Consultans	Gilbert	Arizona	85297	Recruiting
Associated Retina Consultants - Phoenix	Phoenix	Arizona	85020	Recruiting
Phoenix Retina Clinical Trials, LLC - North Phoenix	Phoenix	Arizona	85050	Recruiting
Retina Macula Institute of Arizona	Scottsdale	Arizona	85255	Recruiting
Retina Vitreous Associates Medical Group	Beverly Hills	California	90211	Recruiting
Retina Consultants of Orange County	Fullerton	California	92835	Recruiting
South Coast Retina Center	Long Beach	California	90807	Recruiting
Retinal Consultants Medical Group - Modesto	Modesto	California	95356	Recruiting
Kaiser Permanente	Oakland	California	94611	Recruiting
Retina Consultants of Southern California	Redlands	California	92374	Recruiting
Bay Area Retina Associates	Walnut Creek	California	94598	Recruiting
Retina Specialists of Colorado - Arvada	Arvada	Colorado	80002	Recruiting
Connecticut Eye Consultants, P.C.	Danbury	Connecticut	06810	Recruiting
Coastal Eye Surgeons, LLC	Greenwich	Connecticut	06830	Recruiting
Retina Group of New England, PC	Waterford	Connecticut	06385	Recruiting
Retina Group of Florida - Fort Lauderdale	Fort Lauderdale	Florida	33308	Recruiting
Retina Specialty Institute	Pensacola	Florida	32503	Recruiting
Fort Lauderdale Eye Institute	Plantation	Florida	33324	Recruiting
MedEye Associates	South Miami	Florida	33143	Recruiting
Retina Vitreous Associates of Florida - Saint Petersburg	St. Petersburg	Florida	33711	Recruiting
Retina Vitreous Associates of Florida	Tampa	Florida	33617	Recruiting
Retina Associates	Elmhurst	Illinois	60126	Recruiting
University Retina and Macula Associates	Lemont	Illinois	60439	Recruiting
Illinois Retina Associates, S.C.	Oak Park	Illinois	60304	Recruiting
Associated Vitreoretinal & Uveitis Consultants - Carmel	Carmel	Indiana	46032	Recruiting
The Eye Care Institute	Louisville	Kentucky	40206	Recruiting
Mid Atlantic Retina Specialists - Hagerstown	Hagerstown	Maryland	21740	Recruiting
The Retina Institute	St Louis	Missouri	63128	Recruiting
Retina Center of New Jersey	Bloomfield	New Jersey	07003	Recruiting
Vision Research Center at Eye Associates of New Mexico	Albuquerque	New Mexico	87109	Recruiting
Retina Vitreous Surgeons of CNY, PC	Liverpool	New York	13088	Recruiting
Graystone Eye - Hickory Office	Hickory	North Carolina	28602	Recruiting
North Carolina Retina Associates	Wake Forest	North Carolina	27587	Recruiting
Retina Vitreous Center, PLLC	Edmond	Oklahoma	73013	Recruiting
Verum Research, LLC	Eugene	Oregon	97401	Recruiting
Wills Eye Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Carolinas Centers for Sight, P.C. - Florence Campus	Florence	South Carolina	29501	Recruiting
Charles Retina Institute	Germantown	Tennessee	38138	Recruiting
Austin Clinical Research LLC	Austin	Texas	78750	Recruiting
Retina and Vitreous of Texas	Bellaire	Texas	77401	Recruiting
Retina Consultants of Texas	Bellaire	Texas	77401	Recruiting
San Antonio Eye Center	San Antonio	Texas	78215	Recruiting
Retina Associates of South Texas	San Antonio	Texas	78240	Recruiting
Retina Consultants of Texas	The Woodlands	Texas	77384	Recruiting
Tyler Retina Consultants	Tyler	Texas	75703	Recruiting
Strategic Clinical Research Group, LLC	Willow Park	Texas	76087	Recruiting
The Retina Group of Washington	Fairfax	Virginia	22031	Recruiting
Eye Clinic of Wisconsin	Wausau	Wisconsin	54403	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07449923, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07449923 live on ClinicalTrials.gov.

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