COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
Public ClinicalTrials.gov record NCT07449936. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Study identification
- NCT ID
- NCT07449936
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 240 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 16, 2026 (Actual)
- Primary completion
- Oct 2027 (Estimated)
- Completion
- Oct 2028 (Estimated)
- Last update posted
- Oct 2, 2026
2026 – 2028
United States locations
- U.S. sites
- 53
- U.S. states
- 23
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Retina Consultants | Bakersfield | California | 93309 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Global Research Management, Inc. | Glendale | California | 91204 | — |
| Northern California Retina Vitreous Associates Medical Group INC. | Mountain View | California | 94040 | — |
| Retina Consultants of San Diego | Poway | California | 92064 | — |
| California Eye Specialists Medical Group, Inc. | Redlands | California | 92373 | — |
| Retinal Consultants Medical Group - Parkcenter Drive | Sacramento | California | 95825 | — |
| Retinal Consultants Medical Group | Sacramento | California | 95841 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Colorado Retina Associates | Lakewood | Colorado | 80228 | — |
| Advanced Research LLC Sibia Eye Institute | Boynton Beach | Florida | 33437 | — |
| Advance Medical Research Group, Inc | Deerfield Beach | Florida | 33064 | — |
| Eye Associates of Pinellas | Pinellas Park | Florida | 33782 | — |
| Retina Vitreous Associates of Florida - Saint Petersburg | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Associates | Tallahassee | Florida | 32308 | — |
| Retina Specialists of Tampa | Wesley Chapel | Florida | 33544 | — |
| Georgia Retina | Marietta | Georgia | 30060 | — |
| Retina Consultants of Hawaii | ‘Aiea | Hawaii | 96701 | — |
| Red River Research Partners | Plainfield | Illinois | 60586 | — |
| Midwest Eye Institute - Carmel | Carmel | Indiana | 11220 | — |
| Haik Humble Eye Center | West Monroe | Louisiana | 71291 | — |
| Johns Hopkins Medicine - The Johns Hopkins Hospital Campus - Wilmer Eye Institute | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Retina Specialists - Towson | Towson | Maryland | 21204 | — |
| New England Retina Consultants | Springfield | Massachusetts | 01107 | — |
| Retina Associates of Michigan | Grand Blanc | Michigan | 48439 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| NJRetina Care Center - Teaneck | Teaneck | New Jersey | 07666 | — |
| NJ Retina - Toms River | Toms River | New Jersey | 08755 | — |
| Retina Associates of Western New York | Rochester | New York | 14620 | — |
| VRCNY/Long Island Vitreoretinal Consultants | Westbury | New York | 11590 | — |
| Asheville Eye Associates - Regional Medical Park | Asheville | North Carolina | 28803 | — |
| Cape Fear Retinal Associates, PC | Wilmington | North Carolina | 28401 | — |
| Piedmont Retina Specialists, P.A. - Winston-Salem Office | Winston-Salem | North Carolina | 27103 | — |
| Tulsa Retina Consultant | Tulsa | Oklahoma | 74114 | — |
| Erie Retina Research | Erie | Pennsylvania | 16507 | — |
| Charleston Neuroscience Institute - Beaufort | Beaufort | South Carolina | 29902 | — |
| Retina Consultants of Carolina P.A | Greenville | South Carolina | 29605 | — |
| Tennessee Retina | Nashville | Tennessee | 37203 | — |
| Retina Research Institute of Texas Integrated Clinical Research | Abilene | Texas | 79606 | — |
| Texas Retina Associates | Dallas | Texas | 75231 | — |
| Mt. Olympus Medical Research | Houston | Texas | 77479 | — |
| Retina Consultants of Texas | Katy | Texas | 77494 | — |
| Texas Retina Associates | Plano | Texas | 75075 | — |
| Retina Consultants of Texas | Schertz | Texas | 78154 | — |
| Tyler Retina Consultants | Tyler | Texas | 75703 | — |
| Retina Associates of Utah | Salt Lake City | Utah | 84107 | — |
| Salt Lake Retina | West Jordan | Utah | 84088 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Virginia Retina Center | Warrenton | Virginia | 20186 | — |
| Northeast Wisconsin Retina Associates | Appleton | Wisconsin | 54914 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07449936, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07449936 live on ClinicalTrials.gov.