COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

ClinicalTrials.gov ID: NCT07449936

Public ClinicalTrials.gov record NCT07449936. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 6, 2026, 6:33 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)

Study identification

NCT ID: NCT07449936
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: EyePoint Pharmaceuticals, Inc.; Industry
Enrollment: 240 participants

Conditions and interventions

Conditions

Interventions

Aflibercept (2.0 mg) Drug
EYP-1901 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 15, 2026
Primary completion: Sep 30, 2027
Completion: Sep 30, 2028
Last update posted: May 5, 2026

2026 – 2028

United States locations

U.S. sites: 46
U.S. states: 21
U.S. cities: 45

Facility	City	State	ZIP	Site status
California Retina Consultants	Bakersfield	California	93309	Recruiting
The Retina Partners	Encino	California	91436	Recruiting
Global Research Management, Inc.	Glendale	California	91204	Recruiting
Northern California Retina Vitreous Associates Medical Group INC.	Mountain View	California	94040	Recruiting
Retina Consultants of San Diego	Poway	California	92064	Recruiting
California Eye Specialists Medical Group, Inc.	Redlands	California	92373	Recruiting
Retinal Consultants Medical Group - Parkcenter Drive	Sacramento	California	95825	Recruiting
Retinal Consultants Medical Group	Sacramento	California	95841	Recruiting
Retina Consultants of Southern Colorado	Colorado Springs	Colorado	80909	Recruiting
Colorado Retina Associates	Lakewood	Colorado	80228	Recruiting
Advance Medical Research Group, Inc	Deerfield Beach	Florida	33064	Recruiting
Eye Associates of Pinellas	Pinellas Park	Florida	33782	Recruiting
Southern Vitreoretinal Associates	Tallahassee	Florida	32308	Recruiting
Retina Specialists of Tampa	Wesley Chapel	Florida	33544	Recruiting
Georgia Retina	Marietta	Georgia	30060	Recruiting
Retina Consultants of Hawaii	‘Aiea	Hawaii	96701	Recruiting
Red River Research Partners	Plainfield	Illinois	60586	Recruiting
Midwest Eye Institute - Carmel	Carmel	Indiana	11220	Recruiting
Haik Humble Eye Center	West Monroe	Louisiana	71291	Recruiting
Retina Group of Washington	Chevy Chase	Maryland	20815	Recruiting
Cumberland Valley Retina Consultants	Hagerstown	Maryland	21740	Completed
Retina Specialists - Towson	Towson	Maryland	21204	Recruiting
New England Retina Consultants	Springfield	Massachusetts	01107	Recruiting
Retina Associates of Michigan	Grand Blanc	Michigan	48439	Recruiting
Foundation for Vision Research	Grand Rapids	Michigan	49546	Recruiting
NJRetina Care Center - Teaneck	Teaneck	New Jersey	07666	Recruiting
NJ Retina - Toms River	Toms River	New Jersey	08755	Recruiting
Retina Associates of Western New York	Rochester	New York	14620	Recruiting
VRCNY/Long Island Vitreoretinal Consultants	Westbury	New York	11590	Recruiting
Asheville Eye Associates - Regional Medical Park	Asheville	North Carolina	28803	Recruiting
Cape Fear Retinal Associates, PC	Wilmington	North Carolina	28401	Recruiting
Piedmont Retina Specialists, P.A. - Winston-Salem Office	Winston-Salem	North Carolina	27103	Recruiting
Tulsa Retina Consultant	Tulsa	Oklahoma	74114	Recruiting
Erie Retina Research	Erie	Pennsylvania	16507	Recruiting
Charleston Neuroscience Institute - Beaufort	Beaufort	South Carolina	29902	Recruiting
Retina Consultants of Carolina P.A	Greenville	South Carolina	29605	Recruiting
Tennessee Retina	Nashville	Tennessee	37203	Recruiting
Retina Research Institute of Texas Integrated Clinical Research	Abilene	Texas	79606	Recruiting
Texas Retina Associates	Dallas	Texas	75231	Recruiting
Mt. Olympus Medical Research	Houston	Texas	77479	Recruiting
Retina Consultants of Texas	Katy	Texas	77494	Recruiting
Texas Retina Associates	Plano	Texas	75075	Recruiting
Retina Consultants of Texas	Schertz	Texas	78154	Recruiting
Retina Associates of Utah	Salt Lake City	Utah	84107	Recruiting
Salt Lake Retina	West Jordan	Utah	84088	Recruiting
Piedmont Eye Center	Lynchburg	Virginia	24502	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07449936, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07449936 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →