Phase 2 Study to Assess the Safety and Efficacy of ANG003

ClinicalTrials.gov ID: NCT07450547

Public ClinicalTrials.gov record NCT07450547. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Sep 2, 2026, 3:05 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Multicenter, Randomized, Active-controlled Study to Assess the Safety and Efficacy of ANG003 at Two Different Dose Levels in Subjects With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

In this study, ANG003, a pancreatic enzyme replacement therapy (PERT; commonly called "enzymes"), is being investigated as a potential treatment for exocrine pancreatic insufficiency (EPI). People with EPI due to Cystic Fibrosis (CF) may be eligible to participate in this study. The primary objective of this study is to evaluate the safety of ANG003 and see if it works as well compared to Creon, an approved PERT.

Study identification

NCT ID: NCT07450547
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Anagram Therapeutics, Inc.; Industry
Enrollment: 113 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 23, 2026
Primary completion: Jun 30, 2027
Completion: Jun 30, 2027
Last update posted: Aug 26, 2026

2026 – 2027

United States locations

U.S. sites: 26
U.S. states: 17
U.S. cities: 25

Facility	City	State	ZIP	Site status
Long Beach Memorial Medical Center	Long Beach	California	90806	Recruiting
Center for Cystic Fibrosis at Keck Medical Center of USC	Los Angeles	California	90033	Recruiting
National Jewish Health	Denver	Colorado	80206	Recruiting
University of Florida	Gainesville	Florida	32610	Not yet recruiting
Central Florida Pulmonary Group	Orlando	Florida	32803	Not yet recruiting
The Cystic Fibrosis Institute	Glenview	Illinois	60025	Recruiting
University of Iowa	Iowa City	Iowa	52242	Not yet recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
University of Kentucky	Lexington	Kentucky	40506	Recruiting
MaineHealth Pediatric Specialty Care	Portland	Maine	04102	Not yet recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Not yet recruiting
Boston Children's Hospita	Boston	Massachusetts	02115	Recruiting
University of Michigan, Michigan Medicine	Ann Arbor	Michigan	48109	Recruiting
Wayne State University Harper University Hospital	Detroit	Michigan	48201	Recruiting
Rutgers - Robert Wood Johnson Medical School	New Brunswick	New Jersey	08903	Recruiting
New York Medical College at Westchester Medical Center	Valhalla	New York	10595	Not yet recruiting
Children's Hospital Medical Center of Akron	Akron	Ohio	44308	Recruiting
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Not yet recruiting
Nationwide Children's Hospital, Columbus	Columbus	Ohio	43205	Not yet recruiting
Toledo Children's Hospital	Toledo	Ohio	43606	Recruiting
Hershey Medical Center Pennsylvania State University	Hershey	Pennsylvania	17033	Recruiting
University of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15224	Not yet recruiting
University of Texas Southwestern / Children's Health	Dallas	Texas	75207	Recruiting
Adult Cystic Fibrosis Center at the University of Utah	Salt Lake City	Utah	84112	Not yet recruiting
University of Wisconsin	Madison	Wisconsin	53792	Recruiting
Froedtert & Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07450547, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 26, 2026 · Synced Sep 2, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07450547 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →