Immune Modulation During Palynziq® Treatment in Adults (IMPALA)
Public ClinicalTrials.gov record NCT07477691. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4 Study of Immune Modulation During Palynziq® Treatment in Adults With Phenylketonuria (PKU)
Study identification
- NCT ID
- NCT07477691
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- BioMarin Pharmaceutical
- Industry
- Enrollment
- 12 participants
Conditions and interventions
Conditions
Interventions
- Methotrexate Drug
- Pegvaliase Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2026
- Primary completion
- Sep 29, 2027
- Completion
- Sep 29, 2027
- Last update posted
- Mar 16, 2026
2026 – 2027
United States locations
- U.S. sites
- 12
- U.S. states
- 12
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCLA Dept. of Human Genetics | Los Angeles | California | 90095 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| University Of South Florida Medical Center | Tampa | Florida | 33613 | — |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| University of Minnesota Medical School | Minneapolis | Minnesota | 55455 | — |
| University of Rochester Medical Center (URMC) | Rochester | New York | 14642 | — |
| Oregon Health & Science University (OHSU) - PARENT | Portland | Oregon | 97239 | — |
| University of Pittsburgh Medical Center (UPMC) - Children's Hospital of Pittsburgh | Philadelphia | Pennsylvania | 19104 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84108 | — |
| Children's Hospital of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07477691, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 16, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07477691 live on ClinicalTrials.gov.