A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

ClinicalTrials.gov ID: NCT07481630

Public ClinicalTrials.gov record NCT07481630. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 12:31 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 5)

Study identification

NCT ID: NCT07481630
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 400 participants

Conditions and interventions

Conditions

Interventions

NNC0487-0111 Drug
Placebo (matched to NNC0487-0111 ) Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 12, 2026
Primary completion: Aug 13, 2028
Completion: Aug 13, 2028
Last update posted: May 13, 2026

2026 – 2028

United States locations

U.S. sites: 19
U.S. states: 14
U.S. cities: 19

Facility	City	State	ZIP	Site status
Arizona Research Center, Inc.	Phoenix	Arizona	85053	Recruiting
Diablo Clinical Research, Inc.	Walnut Creek	California	94598	Recruiting
Chase Medical Research LLC	Hamden	Connecticut	06517	Recruiting
Chase Medical Research LLC	Waterbury	Connecticut	06708	Recruiting
Zenith clinical research	Hollywood	Florida	33021	Recruiting
CNS Healthcare	Jacksonville	Florida	32256	Recruiting
Angels Clinical Research Institute	Miami Lakes	Florida	33016	Recruiting
Hope Clin Res & Wellness	Conyers	Georgia	30094	Recruiting
CenExel iResearch, LLC	Decatur	Georgia	30030	Recruiting
Elite Clinical Trials	Blackfoot	Idaho	83221	Recruiting
MedVadis Research Watertown	Waltham	Massachusetts	02451	Recruiting
Jubilee Clinical Research, Inc.	Las Vegas	Nevada	89106	Recruiting
Great Lakes Medical Research	Westfield	New York	14787	Recruiting
Accellacare and KDCILM, LLC	Wilmington	North Carolina	28401	Recruiting
Coastal Carolina Res Ctr	North Charleston	South Carolina	29405	Recruiting
VIP Trials_San Antonio	San Antonio	Texas	78230	Recruiting
Charlottesville Med Research	Charlottesville	Virginia	22911	Recruiting
Health Res of Hampton Roads	Newport News	Virginia	23606	Recruiting
Northwest Clinical Research Center	Bellevue	Washington	98007	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 57 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07481630, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 13, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07481630 live on ClinicalTrials.gov.

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