A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Public ClinicalTrials.gov record NCT07481630. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 5)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and knee osteoarthritis. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Study identification
- NCT ID
- NCT07481630
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 400 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 12, 2026
- Primary completion
- Aug 13, 2028
- Completion
- Aug 13, 2028
- Last update posted
- Jul 8, 2026
2026 – 2028
United States locations
- U.S. sites
- 19
- U.S. states
- 14
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Research Center, Inc. | Phoenix | Arizona | 85053 | Recruiting |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | Recruiting |
| Chase Medical Research LLC | Hamden | Connecticut | 06517 | Recruiting |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | Recruiting |
| Zenith clinical research | Hollywood | Florida | 33021 | Recruiting |
| CNS Healthcare | Jacksonville | Florida | 32256 | Recruiting |
| Angels Clinical Research Institute | Miami Lakes | Florida | 33016 | Recruiting |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | Recruiting |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | Recruiting |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | Recruiting |
| MedVadis Research Watertown | Waltham | Massachusetts | 02451 | Recruiting |
| Jubilee Clinical Research, Inc. | Las Vegas | Nevada | 89106 | Recruiting |
| Great Lakes Medical Research | Westfield | New York | 14787 | Recruiting |
| Accellacare and KDCILM, LLC | Wilmington | North Carolina | 28401 | Recruiting |
| Coastal Carolina Res Ctr | North Charleston | South Carolina | 29405 | Recruiting |
| VIP Trials_San Antonio | San Antonio | Texas | 78230 | Recruiting |
| Charlottesville Med Research | Charlottesville | Virginia | 22911 | Recruiting |
| Health Res of Hampton Roads | Newport News | Virginia | 23606 | Recruiting |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 57 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07481630, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2026 · Synced Sep 11, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07481630 live on ClinicalTrials.gov.