A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Public ClinicalTrials.gov record NCT07496567. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-masked, Multicenter, 3-arm, Pivotal Phase 2/3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) EYE201/MK-8748 Compared to Aflibercept (2 mg) in Participants With Neovascular Age-related Macular Degeneration (NVAMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.
Study identification
- NCT ID
- NCT07496567
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 960 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 14, 2026
- Primary completion
- Jul 30, 2028
- Completion
- Jul 30, 2028
- Last update posted
- Aug 5, 2026
2026 – 2028
United States locations
- U.S. sites
- 52
- U.S. states
- 25
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants - Gilbert | Gilbert | Arizona | 85259 | Recruiting |
| The Retina Partners | Encino | California | 91436 | Recruiting |
| Northern California Retina Vitreous Associates Medical Group, Inc. | Mountain View | California | 94040 | Recruiting |
| Orange County Retina Medical Group | Santa Ana | California | 92705 | Recruiting |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | Recruiting |
| RSC Research LLC | Denver | Colorado | 80222 | Recruiting |
| Retina Consultants of Southern Colorado | Pueblo | Colorado | 81008 | Recruiting |
| Connecticut Eye Consultants, P.C. | Danbury | Connecticut | 06810 | Recruiting |
| Retina Consultants, P.C. | Manchester | Connecticut | 06042 | Recruiting |
| Retina Group of New England | Waterford | Connecticut | 06385 | Recruiting |
| Retina Group of Florida | Fort Myers | Florida | 33912 | Recruiting |
| Florida Retina Institute | Orlando | Florida | 32806 | Recruiting |
| Retina Group of Florida (Site 065) | Sarasota | Florida | 34232 | Recruiting |
| Center for Retina and Macular Disease (Site 062) | Winter Haven | Florida | 33880 | Recruiting |
| Illinois Retina Associates | Joliet | Illinois | 60435 | Recruiting |
| University Retina & Macula Associates, P.C. | Lemont | Illinois | 60439 | Recruiting |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | Recruiting |
| Retina Associates, LLC | Lenexa | Kansas | 66215 | Recruiting |
| Butchertown Clinical Trials | Louisville | Kentucky | 40206 | Recruiting |
| Maine Eye Center (Site 097) | Portland | Maine | 04101 | Recruiting |
| Mid Atlantic Retina Specialists | Hagerstown | Maryland | 21740 | Recruiting |
| Retina Research Institute at New England Retina Consultants, PC | Springfield | Massachusetts | 01107 | Recruiting |
| Retina Consultants of Minnesota | Edina | Minnesota | 55435 | Recruiting |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | Recruiting |
| Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY | Great Neck | New York | 11021 | Recruiting |
| Retina Associates of Western NY, PC (Site 051) | Rochester | New York | 14620 | Recruiting |
| Asheville Eye Associates, Retina Division (Site 077) | Asheville | North Carolina | 28803 | Recruiting |
| NC Retina | Cary | North Carolina | 27511 | Recruiting |
| Graystone Eye | Hickory | North Carolina | 28602 | Recruiting |
| NC Retina Associates | Wake Forest | North Carolina | 27587 | Recruiting |
| Retina Consultants, LLC | Salem | Oregon | 97302 | Recruiting |
| Cascade Medical Research Institute, LLC | Springfield | Oregon | 97477 | Recruiting |
| Erie Retina Research | Erie | Pennsylvania | 16505 | Recruiting |
| Charleston Neuroscience Institute (Site 034) | Beaufort | South Carolina | 29902 | Recruiting |
| Palmetto Retina Center | Florence | South Carolina | 29501 | Recruiting |
| Charleston Neuroscience Institute | Ladson | South Carolina | 29456 | Recruiting |
| Palmetto Retina Center | West Columbia | South Carolina | 29169 | Recruiting |
| Southeastern Retina Associates | Hixson | Tennessee | 37343 | Recruiting |
| Southeastern Retina Associates (Site 095) | Johnson City | Tennessee | 37604 | Recruiting |
| Southeastern Retina Associates, P.C. | Knoxville | Tennessee | 37922 | Recruiting |
| Tennessee Retina | Nashville | Tennessee | 37203 | Recruiting |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | Recruiting |
| Texas Retina Associates | Fort Worth | Texas | 76104 | Recruiting |
| Retina Consultants of Texas | Katy | Texas | 77494 | Recruiting |
| Austin Retina Associates | Round Rock | Texas | 78681 | Recruiting |
| Retina Consultants of Texas | San Antonio | Texas | 78240 | Recruiting |
| Austin Retina Associates | San Marcos | Texas | 78666 | Recruiting |
| Retina Consultants of Texas | Schertz | Texas | 78154 | Recruiting |
| Salt Lake Retina | West Jordan | Utah | 84088 | Recruiting |
| Vistar Eye Center (Site 129) | Roanoke | Virginia | 24019 | Recruiting |
| Pacific Northwest Retina | Bellevue | Washington | 98004 | Recruiting |
| Northeast Wisconsin Retina Associates | Appleton | Wisconsin | 54914 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 19 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07496567, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07496567 live on ClinicalTrials.gov.