AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

ClinicalTrials.gov ID: NCT07509307

Public ClinicalTrials.gov record NCT07509307. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 8:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Knee Osteoarthritis (AMAZE 6)

Study identification

NCT ID: NCT07509307
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 400 participants

Conditions and interventions

Conditions

Interventions

NNC0487-0111 Drug
Placebo (matched to NNC0487-0111) Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 19, 2026
Primary completion: Aug 13, 2028
Completion: Aug 13, 2028
Last update posted: May 14, 2026

2026 – 2028

United States locations

U.S. sites: 19
U.S. states: 13
U.S. cities: 17

Facility	City	State	ZIP	Site status
Neighborhood Healthcare	Escondido	California	92025	Recruiting
First Valley Medical Group	Lancaster	California	93534	Not yet recruiting
Desert Oasis Healthcare	Palm Springs	California	92262	Recruiting
Chase Medical Research LLC	Waterbury	Connecticut	06708	Recruiting
Westside Center For Clinical Research	Jacksonville	Florida	32205	Recruiting
CNS Healthcare	Jacksonville	Florida	32256	Recruiting
Advanced Res for Health Improve	Naples	Florida	34102	Recruiting
Clinical Investigation Spec Gurnee	Gurnee	Illinois	60031	Recruiting
Evanston Premier Hlthcr Res	Skokie	Illinois	60077	Recruiting
Monroe Biomedical Research, LLC	Louisville	Kentucky	40213	Recruiting
Arcturus Healthcare, PLC.	Troy	Michigan	48098-6368	Recruiting
Clinvest Research	Springfield	Missouri	65807	Recruiting
NYU Langone Orthopedic Center	New York	New York	10016	Not yet recruiting
Hospital For Special Surgery	New York	New York	10021	Not yet recruiting
Piedmont Healthcare/Research	Statesville	North Carolina	28625	Recruiting
Northwest Research Center	Portland	Oregon	97202	Recruiting
Mercy Family Clinic	Dallas	Texas	75208	Not yet recruiting
Health Res of Hampton Roads	Newport News	Virginia	23606	Recruiting
Northwest Clinical Research Center	Bellevue	Washington	98007	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07509307, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 14, 2026 · Synced May 20, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07509307 live on ClinicalTrials.gov.

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