An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED
Public ClinicalTrials.gov record NCT07519902. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 3, Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Recombinant Human Nerve Growth Factor Eye Drop Solution in Participants With Persistent Corneal Epithelial Defect (PCED)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 3, randomized, multicenter, double-masked, parallel group, vehicle-controlled prospective clinical trial to evaluate the safety and efficacy of cenegermin in inducing complete epithelial healing in participants with PCED. The primary objective is the evaluation of complete epithelial healing after 4 weeks of treatment. The study is comprised of 3 periods: an 8-week initial treatment period (Day 1 to Week 8), an 8-week extension treatment period (Week 9 to Week 16), and a 24-week follow-up period (Week 17 to Week 40).
Study identification
- NCT ID
- NCT07519902
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 150 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 1, 2026
- Primary completion
- Nov 30, 2027
- Completion
- Nov 30, 2027
- Last update posted
- Jul 15, 2026
2026 – 2027
United States locations
- U.S. sites
- 18
- U.S. states
- 11
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Azul Vision, INC | Huntington Beach | California | 92647 | Recruiting |
| Harvard Eye Associates | Laguna Hills | California | 92653 | Recruiting |
| Loma Linda University Adventist Health Sciences Center | Loma Linda | California | 92354 | Not yet recruiting |
| UCLA - Jules Stein Eye Institute (JSEI) - Diabetic Eye Dise | Los Angeles | California | 90095 | Not yet recruiting |
| California Eye Specialists Medical Group, Inc. | Redlands | California | 92373 | Recruiting |
| East Coast Institute for Research - Florida Eye Specialists | Jacksonville | Florida | 32207 | Recruiting |
| Bascom Palmer Eye Institute, University of Miami School of Medicine | Miami | Florida | 33136 | Recruiting |
| University of South Florida | Tampa | Florida | 33620 | Recruiting |
| Massachusetts Eye and Ear | Boston | Massachusetts | 02114 | Recruiting |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | Recruiting |
| University of Michigan Health - Kellogg Eye Center | Ann Arbor | Michigan | 48105 | Not yet recruiting |
| Midwest Vision Research Foundation | Chesterfield | Missouri | 63017 | Recruiting |
| NYU Langone Eye Center (Ophthalmology) | New York | New York | 10017 | Not yet recruiting |
| Duke Eye Center - Ophthalmology | Durham | North Carolina | 27705 | Not yet recruiting |
| Vance Thompson Vision - Sioux Falls | Sioux Falls | South Dakota | 57108 | Recruiting |
| Houston Eye Associates (HEA) | Houston | Texas | 77030 | Recruiting |
| The Eye Institute of Utah | Salt Lake City | Utah | 84107 | Recruiting |
| Virginia Eye Consultants | Norfolk | Virginia | 23502 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07519902, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 15, 2026 · Synced Sep 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07519902 live on ClinicalTrials.gov.