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Recruiting Phase 2 Interventional

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

ClinicalTrials.gov ID: NCT07553637

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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT07553637. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Nov 13, 2026, 9:23 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled Trial of ALTO-207 in Adults With Treatment-resistant Depression

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD.

Study identification

NCT ID
NCT07553637
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Alto Neuroscience
Industry
Enrollment
178 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 20, 2026 (Actual)
Primary completion
Nov 2027 (Estimated)
Completion
Dec 2027 (Estimated)
Last update posted
Oct 26, 2026

2026 – 2027

United States locations

U.S. sites
53
U.S. states
22
U.S. cities
52
Facility City State ZIP Site status
Site 7173 Dothan Alabama 36345 Recruiting
Site 7000 Phoenix Arizona 85012 Recruiting
Site 7153 Chino California 91710 Recruiting
Site 7195 La Jolla California 92037 Not yet recruiting
Site 7069 Los Angeles California 99025 Recruiting
Site 7156 Oakland California 94610 Recruiting
Site 7082 Oceanside California 92056 Recruiting
Site 7159 Palo Alto California 94304 Not yet recruiting
Site 7016 Sacramento California 95655 Recruiting
Site 7144 San Diego California 92123 Recruiting
Site 7120 San Jose California 95124 Recruiting
Site 7171 Valley Village California 91607 Recruiting
Site 7200 Wilton Connecticut 06897 Not yet recruiting
Site 7152 Saint Augustine Florida 32086 Recruiting
Site 7148 Albany Georgia 31707 Recruiting
Site 7146 Marietta Georgia 30060 Recruiting
Site 7141 Savannah Georgia 31406 Recruiting
Site 7064 Snellville Georgia 30078 Recruiting
Site 7192 Naperville Illinois 60563 Recruiting
Site 7169 Indianapolis Indiana 46202 Recruiting
Site 7151 Annapolis Maryland 21401 Withdrawn
Site 7185 Baltimore Maryland 21205 Not yet recruiting
Site 7054 Pikesville Maryland 21208 Recruiting
Site 7180 Rockville Maryland 20852 Recruiting
Site 7166 Worcester Massachusetts 01605 Recruiting
Site 7155 Ann Arbor Michigan 48109 Recruiting
Site 7154 Bloomfield Hills Michigan 48302 Recruiting
Site 7178 Grand Rapids Michigan 49501 Not yet recruiting
Site 7189 St Louis Missouri 63128 Recruiting
Site 7066 Toms River New Jersey 08755 Recruiting
Site 7170 Amherst New York 14226 Recruiting
Site 7055 Cedarhurst New York 11516 Recruiting
Site 7162 Lewiston New York 14092 Recruiting
Site 7157 Syracuse New York 13210 Recruiting
Site 7127 Cary North Carolina 27511 Recruiting
Site 7143 Charlotte North Carolina 28287 Recruiting
Site 7029 Cincinnati Ohio 45215 Recruiting
Site 7194 Dayton Ohio 45459 Not yet recruiting
Site 7158 Garfield Heights Ohio 44125 Recruiting
Site 7172 East Providence Rhode Island 02914 Recruiting
Site 7191 North Myrtle Beach South Carolina 29582 Not yet recruiting
Site 7199 Austin Texas 78731 Not yet recruiting
Site 7190 Bryan Texas 77802 Not yet recruiting
Site 7176 Dallas Texas 75243 Recruiting
Site 7160 Fort Worth Texas 76104 Recruiting
Site 7150 Galveston Texas 77555 Not yet recruiting
Site 7175 Houston Texas 77007 Recruiting
Site 7145 Houston Texas 77030 Recruiting
Site 7161 Irving Texas 75062 Recruiting
Site 7186 Plano Texas 75024 Recruiting
Site 7177 Fairfax Virginia 22030 Recruiting
Site 7128 Seattle Washington 98004 Active, not recruiting
Site 7163 South Charleston West Virginia 25303 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07553637, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 26, 2026 · Synced Nov 13, 2026

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