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Recruiting Phase 3 Interventional

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

ClinicalTrials.gov ID: NCT07571109

Public ClinicalTrials.gov record NCT07571109. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 11, 2026, 10:31 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Efficacy and Safety of NNC0487-0111 s.c. Once-weekly in Participants With Overweight or Obesity, and Obstructive Sleep Apnoea Treated With Positive Airway Pressure (AMAZE 4)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.

Study identification

NCT ID
NCT07571109
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novo Nordisk A/S
Industry
Enrollment
300 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 4, 2026
Primary completion
Jun 25, 2028
Completion
Aug 20, 2028
Last update posted
Sep 8, 2026

2026 – 2028

United States locations

U.S. sites
20
U.S. states
11
U.S. cities
19
Facility City State ZIP Site status
Dignity Health, Mercy Gilbert Gilbert Arizona 85297 Recruiting
DM Clinical Bradenton Florida 34209 Recruiting
Essence MD Research Naples Florida 34102 Recruiting
Palm Beach Research Center West Palm Beach Florida 33409 Recruiting
NeuroTrials Research, Inc. Atlanta Georgia 30328 Recruiting
Physicians Research Associates Lawrenceville Georgia 30046 Recruiting
Chicago Research Center, Inc Chicago Illinois 60634 Recruiting
Weil Cornell Medicine New York New York 10021 Recruiting
Lillestol Research LLC Fargo North Dakota 58104 Recruiting
CTI Clinical Research Center Cincinnati Ohio 45212 Recruiting
Clinical Research Associates of Central PA, LLC DuBois Pennsylvania 15801 Not yet recruiting
Bogan Sleep Consultants, LLC Columbia South Carolina 29201 Recruiting
Epic Medical Research DeSoto Texas 75115 Recruiting
Advanced Neurology Epilepsy and Sleep Center ANESC El Paso Texas 79912 Recruiting
Biorhythms Center for Integrative Sleep Medicine El Paso Texas 79912 Recruiting
Houston Pulm Med Res Network Houston Texas 77089 Recruiting
Sleep Therapy Research Center San Antonio Texas 78229 Recruiting
Tricoastal Sleep Center Sugar Land Texas 77478 Recruiting
Rainier Clin Res Ctr Inc Renton Washington 98057 Recruiting
Seattle Clinical Research Center Seattle Washington 98104 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 72 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07571109, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 8, 2026 · Synced Sep 11, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07571109 live on ClinicalTrials.gov.

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