A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity
Public ClinicalTrials.gov record NCT07575932. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE-RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).
Study identification
- NCT ID
- NCT07575932
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 940 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 11, 2026 (Actual)
- Primary completion
- Aug 4, 2027 (Estimated)
- Completion
- Jan 5, 2028 (Estimated)
- Last update posted
- Oct 13, 2026
2026 – 2028
United States locations
- U.S. sites
- 53
- U.S. states
- 20
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Institute of Arizona | Sun City West | Arizona | 85375 | — |
| San Fernando Valley Health Institute | Canoga Park | California | 91304 | — |
| Ark Clinical Research | Fountain Valley | California | 92708 | — |
| Paragon Rx Clinical | Garden Grove | California | 92840 | — |
| Torrance Clinical Research Institute, Inc. | Lomita | California | 90717 | — |
| Ark Clinical Research | Long Beach | California | 90815 | — |
| Collaborative Neuroscience Research, LLC | Los Alamitos | California | 90720 | — |
| Paradigm Clinical Research-Modesto | Modesto | California | 95355 | — |
| Paradigm Clinical Research Centers, LLC | San Diego | California | 92108 | — |
| University Clinical Investigators, Incorporated | Tustin | California | 92780 | — |
| Diablo Clinical Research, LLC dba Flourish Research | Walnut Creek | California | 94598 | — |
| AGA Clinical Trials | Hialeah | Florida | 33012 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Charter Research | Orlando | Florida | 32803 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Koch Family Medicine Clinical Research/Elite Research Network | Morton | Illinois | 61550 | — |
| Bioluminux Clinical Research Illinois | Naperville | Illinois | 60540 | — |
| Johnson County Clinical Trials | Lenexa | Kansas | 66219 | — |
| DelRicht Research | Mandeville | Louisiana | 70471 | — |
| DelRicht Research | Prairieville | Louisiana | 70769 | — |
| Patient First Clinical Trials (PFCTRIALS) | Lutherville | Maryland | 21093 | — |
| DelRicht Research | Springfield | Missouri | 65807 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Alliance Clinical Research Las Vegas (Excel Clinical Research) | Las Vegas | Nevada | 89109 | — |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | — |
| Palm Research Center | Las Vegas | Nevada | 89128 | — |
| Bioluminux Clinical Research | Hamilton | New Jersey | 08690 | — |
| DelRicht Research | Charlotte | North Carolina | 28211 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Piedmont Healthcare | Statesville | North Carolina | 28625 | — |
| Accellacare - Wilmington | Wilmington | North Carolina | 28401 | — |
| Tekton Research, LLC. | Oklahoma City | Oklahoma | 73134 | — |
| Preferred Primary Care Physicians | Pittsburgh | Pennsylvania | 15236 | — |
| Preferred Primary Care Physicians, Inc. | Uniontown | Pennsylvania | 15401 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| TMA Headlands LLC (d/b/a Trial Management Associates) | Myrtle Beach | South Carolina | 29572 | — |
| DelRicht Research | Hendersonville | Tennessee | 37075 | — |
| Cedar Health Research - Euless | Euless | Texas | 76040 | — |
| JCCT-JUNO NW Houston | Houston | Texas | 77040 | — |
| Activian Clinical Research | Kingwood | Texas | 77339 | — |
| 3A Research | Plano | Texas | 75093 | — |
| DelRicht Research @ Zomnir Family Medicine | Prosper | Texas | 75078 | — |
| Worldwide Clinical Trials | San Antonio | Texas | 78217 | — |
| Tekton Research, LLC. | San Antonio | Texas | 78258 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Alpine Medical Group | Salt Lake City | Utah | 84102 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
| Washington Center for Weight Management and Research | Arlington | Virginia | 22206 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| DelRicht Research | Vienna | Virginia | 22182 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07575932, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07575932 live on ClinicalTrials.gov.