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Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: ADHF Clear all
Completed Not applicable Interventional Accepts healthy volunteers

A Study to Evaluate Lung Ultrasound as a Method to Measure Changes in Extravascular Lung Water Induced by Positional Changes (LUPE)

NCT03146754
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Methodology
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated Phase 2 Interventional

ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure

NCT00283361
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
ZP120, I.v. catherization, 6-minutes walk performance, Dyspnea severity assessment, Blood sampling for laboratory tests, ECG, Physical examination
Drug · Procedure · Behavioral
Lead sponsor
Zealand Pharma
Industry
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
22
States / cities
Los Angeles, California • San Diego, California • San Francisco, California + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 27, 2007 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Interleukin (IL)-1 Blockade in Acute Heart Failure (Anakinra ADHF)

NCT01936844
View directory record Official record
Conditions
Heart Failure
Interventions
Anakinra (high dose), Anakinra (standard dose), Placebo
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 99 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated May 4, 2016 · Synced Jul 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

POCUS-Guided Diuresis for Decompensated Heart Failure

NCT06921603
View directory record Official record
Conditions
Heart Decompensation, Acute, Acute Kidney Injuries
Interventions
Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 22, 2026, 10:05 AM EDT
Recruiting Phase 3 Interventional

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

NCT06898515
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Reprieve System, furosemide infusion
Device · Drug
Lead sponsor
Reprieve Cardiovascular, Inc
Industry
Eligibility
22 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
37
States / cities
Irvine, California • La Jolla, California • Sacramento, California + 31 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jul 22, 2026, 10:05 AM EDT
Withdrawn Phase 4 Interventional

Intravenous Vasodilator vs. Inotropic Therapy in Patients With Heart Failure

NCT02767024
View directory record Official record
Conditions
Acute Heart Failure
Interventions
Sodium nitroprusside, Dobutamine, Furosemide
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced Jul 22, 2026, 10:05 AM EDT
Recruiting No phase listed Observational

Voice Analysis for Monitoring Patients With Heart Failure

NCT06566911
View directory record Official record
Conditions
Heart Failure
Interventions
Not listed
Lead sponsor
Noah Labs
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 21, 2024 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy

NCT01121107
View directory record Official record
Conditions
Heart Failure
Interventions
Left Atrial Pressure Monitoring System, Patient Advisory Module
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
486 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2015
U.S. locations
63
States / cities
Phoenix, Arizona • Fullerton, California • Glendale, California + 51 more
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Phase 1 Interventional

PK/PD Study of Subcutaneous Cenderitide Infusion in CHF Patients

NCT01316432
View directory record Official record
Conditions
Heart Failure, ADHF, Chronic Heart Failure, CHF
Interventions
Cenderitide, Placebo
Drug · Other
Lead sponsor
Nile Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
5
States / cities
Tustin, California • Jacksonville, Florida • Lenexa, Kansas + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 17, 2012 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated Phase 2 Interventional Results available

Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study

NCT03170219
View directory record Official record
Conditions
Acute Heart Failure, Decompensated Heart Failure
Interventions
subcutaneous furosemide and sc2wear device
Combination Product
Lead sponsor
Adrian Hernandez
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
16
States / cities
Atlanta, Georgia • Chicago, Illinois • Baltimore, Maryland + 8 more
Source: ClinicalTrials.gov public record
Updated Jan 22, 2019 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated Not applicable Interventional Results available

Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics

NCT01457053
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration
Drug · Other
Lead sponsor
University of Cincinnati
Other
Eligibility
18 Years and older
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Jul 22, 2026, 10:05 AM EDT
Completed No phase listed Observational

Neutrophil Gelatinase-Associated Lipcalin (NGAL) Evaluation Along With B-Type Natriuretic Peptide in Acutely Decompensated HF

NCT00693745
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Not listed
Lead sponsor
Abbott RDx Cardiometabolic
Other
Eligibility
18 Years and older
Enrollment
231 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
3
States / cities
San Diego, California • Brooklyn, New York • Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2010 · Synced Jul 22, 2026, 10:05 AM EDT
Completed No phase listed Observational

Biomonitoring and Cardiorenal Syndrome in Heart Failure(BIONICS-HF) Trial

NCT01570153
View directory record Official record
Conditions
Cardiorenal Syndrome, Acute Decompensated Heart Failure
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 23, 2014 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Phase 1 Interventional Results available

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

NCT02877095
View directory record Official record
Conditions
Acute Heart Failure
Interventions
Furosemide
Drug
Lead sponsor
Adrian Hernandez
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
5
States / cities
Atlanta, Georgia • Boston, Massachusetts • Rochester, Minnesota + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 14, 2019 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated Phase 2 Interventional

BAY58-2667 Dose Finding Trial Investigating Fixed Doses in Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF)

NCT01065077
View directory record Official record
Conditions
Acute Heart Failure
Interventions
Cinaciguat (BAY58-2667), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
6
States / cities
Ridgewood, New Jersey • Winston-Salem, North Carolina • Cleveland, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 7, 2015 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated No phase listed Observational

Correlating Noninvasive Cardiovascular Measures to Left Ventricular End Diastolic Pressure in Heart Failure

NCT02406820
View directory record Official record
Conditions
Heart Failure
Interventions
Non-invasive hemodynamic monitoring (CVInsight™ [CVI])
Device
Lead sponsor
Intelomed, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Aug 29, 2016 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional Results available

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve Decongestion Management System (DMS)

NCT05174312
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Reprieve Decongestion Management System, Diuretic
Device · Drug
Lead sponsor
Reprieve Cardiovascular, Inc
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
16
States / cities
Fairhope, Alabama • Irvine, California • Washington D.C., District of Columbia + 12 more
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Jul 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Care Coordination to Assess Improvement in Outcomes in Hospital Readmissions

NCT04905160
View directory record Official record
Conditions
Heart Failure, ADHF, Acute MI
Interventions
COMPASSION Digital Biomarker
Other
Lead sponsor
Aventyn, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Phase 3 Interventional

Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

NCT00709865
View directory record Official record
Conditions
Renal Insufficiency, Congestive Heart Failure
Interventions
tonapofylline, Placebo
Drug
Lead sponsor
Biogen
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
68
States / cities
Huntsville, Alabama • Mobile, Alabama • Fort Smith, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated Sep 10, 2023 · Synced Jul 22, 2026, 10:05 AM EDT
Recruiting Not applicable Interventional

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

NCT05677100
View directory record Official record
Conditions
Heart Failure, Cardiorenal Syndrome, Cardio-Renal Syndrome, ADHF, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure; With Decompensation, Heart Failure, Congestive
Interventions
Aortix System
Device
Lead sponsor
Procyrion
Industry
Eligibility
21 Years and older
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
48
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Concord, California + 36 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated Phase 4 Interventional Results available

Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure

NCT00904488
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Addition of oral Metolazone, Furosemide dose escalation
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2017
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Jul 22, 2026, 10:05 AM EDT
Terminated No phase listed Observational

Assay to Measure Beta Blocker Adherence

NCT05251974
View directory record Official record
Conditions
Congestive Heart Failure, Medication Adherence
Interventions
Quest beta blocker assay
Diagnostic Test
Lead sponsor
Summa Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Not applicable Interventional

Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure

NCT06592508
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Remote Virtual Cardiology Program
Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
5
States / cities
Panama City, Florida • Gainesville, Georgia • Raleigh, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jul 22, 2026, 10:05 AM EDT
Completed Phase 2 Interventional Results available

A Study of Ultra High Dose Diuretics to Treat Heart Failure

NCT06036914
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Bumetanide, Furosemide
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced Jul 22, 2026, 10:05 AM EDT