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ClinicalTrials.gov public records Last synced May 22, 2026, 1:39 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 100 matching trials from the live ClinicalTrials.gov search.
Local D1 index available.
Filters: Condition: ADHF Clear all
Withdrawn Phase 4 Interventional
View directory record Official record
Conditions
Hemolysis Intravascular, Acute Decompensated Heart Failure
Interventions
Pentoxifylline Oral Product, Placebo
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced May 22, 2026, 1:39 AM EDT
Terminated Phase 3 Interventional Results available
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Experimental: Placebo, Experimental: Metolazone
Drug
Lead sponsor
Aultman Health Foundation
Other
Eligibility
18 Years and older
Enrollment
147 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Canton, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 14, 2019 · Synced May 22, 2026, 1:39 AM EDT
Completed Phase 2 Interventional Results available
View directory record Official record
Conditions
Heart Failure; With Decompensation
Interventions
Bumetanide, Furosemide
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 13, 2026 · Synced May 22, 2026, 1:39 AM EDT
Completed Phase 3 Interventional
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Ularitide, Placebo
Drug
Lead sponsor
Cardiorentis
Industry
Eligibility
18 Years to 85 Years
Enrollment
2,157 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
39
States / cities
Huntsville, Alabama • Montgomery, Alabama • Sacramento, California + 34 more
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced May 22, 2026, 1:39 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Cardiogenic Shock, Acute Decompensated Heart Failure
Interventions
Impella 5.5
Device
Lead sponsor
Abiomed Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,017 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
15
States / cities
Los Angeles, California • Orlando, Florida • Tampa, Florida + 11 more
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced May 22, 2026, 1:39 AM EDT
Terminated Phase 2 Interventional
View directory record Official record
Conditions
Acute Decompensated Heart Failure; Renal Dysfunction
Interventions
SLV320, Placebo
Drug
Lead sponsor
Solvay Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
28
States / cities
Alameda, California • Banning, California • Inglewood, California + 24 more
Source: ClinicalTrials.gov public record
Updated Sep 16, 2010 · Synced May 22, 2026, 1:39 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Congestive Heart Failure
Interventions
Noninvasive Hemodynamic Measurement System
Diagnostic Test
Lead sponsor
Rodin Scientific LLC
Industry
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 25, 2019 · Synced May 22, 2026, 1:39 AM EDT
Completed Not applicable Interventional Results available
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
multi-domain rehabilitation intervention, Attention Control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years and older
Enrollment
349 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
3
States / cities
Durham, North Carolina • Winston-Salem, North Carolina • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 23, 2021 · Synced May 22, 2026, 1:39 AM EDT
Withdrawn Phase 4 Interventional
View directory record Official record
Conditions
Acute Heart Failure
Interventions
Sodium nitroprusside, Dobutamine, Furosemide
Drug
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 30, 2018 · Synced May 22, 2026, 1:39 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Reprieve Decongestion Management System, Diuretic
Device · Drug
Lead sponsor
Reprieve Cardiovascular, Inc
Industry
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
16
States / cities
Fairhope, Alabama • Irvine, California • Washington D.C., District of Columbia + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced May 22, 2026, 1:39 AM EDT
Active, not recruiting Phase 1Phase 2 Interventional
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Atibuclimab (IC14)
Drug
Lead sponsor
Implicit Bioscience
Industry
Eligibility
21 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Charlottesville, Virginia • Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced May 22, 2026, 1:39 AM EDT
Terminated Phase 4 Interventional
View directory record Official record
Conditions
Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure Acute, Cardiovascular Diseases
Interventions
Metolazone Oral Tablet, Chlorothiazide Injection
Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 15, 2021 · Synced May 22, 2026, 1:39 AM EDT
Terminated Phase 4 Interventional Results available
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
SGLT2i, No SGLT2i
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 3, 2024 · Synced May 22, 2026, 1:39 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Heart Decompensation, Acute, Acute Kidney Injuries
Interventions
Furosemide (Standard Diuretic) Treatment, POCUS-Assessed Diuretic Management
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
588 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
5
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced May 22, 2026, 1:39 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
Acute Decompensated Heart Failure, Heart Failure
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
18 Years and older
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2027
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 11, 2025 · Synced May 22, 2026, 1:39 AM EDT
Suspended No phase listed Observational
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Not listed
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 7, 2026 · Synced May 22, 2026, 1:39 AM EDT
Withdrawn Phase 1 Interventional
View directory record Official record
Conditions
Heart Failure, Congestive
Interventions
Ularitide
Drug
Lead sponsor
Facet Biotech
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
8
States / cities
San Diego, California • Atlanta, Georgia • Chicago, Illinois + 5 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2009 · Synced May 22, 2026, 1:39 AM EDT
Withdrawn Phase 4 Interventional
View directory record Official record
Conditions
Heart Failure, Congestive, Dyspnea, Pulmonary Edema
Interventions
Nesiritide
Drug
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 10, 2015 · Synced May 22, 2026, 1:39 AM EDT
Terminated No phase listed Observational
View directory record Official record
Conditions
Congestive Heart Failure, Medication Adherence
Interventions
Quest beta blocker assay
Diagnostic Test
Lead sponsor
Summa Health System
Other
Eligibility
18 Years to 89 Years
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Akron, Ohio
Source: ClinicalTrials.gov public record
Updated Nov 21, 2023 · Synced May 22, 2026, 1:39 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Heart Failure, ADHF, Acute MI
Interventions
COMPASSION Digital Biomarker
Other
Lead sponsor
Aventyn, Inc.
Industry
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Phoenix, Arizona
Source: ClinicalTrials.gov public record
Updated Mar 19, 2024 · Synced May 22, 2026, 1:39 AM EDT
Completed No phase listed Observational
View directory record Official record
Conditions
Acute Decompensated Heart Failure, Heart Failure
Interventions
Not listed
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 13, 2018 · Synced May 22, 2026, 1:39 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
Methodology
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
21 Years and older
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 20, 2023 · Synced May 22, 2026, 1:39 AM EDT
Recruiting No phase listed Observational
View directory record Official record
Conditions
CHF, ADHF, Control
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 12, 2025 · Synced May 22, 2026, 1:39 AM EDT
Completed Not applicable Interventional
View directory record Official record
Conditions
Acute Decompensated Heart Failure
Interventions
BVA-100
Diagnostic Test
Lead sponsor
Daxor Corporation
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 28, 2023 · Synced May 22, 2026, 1:39 AM EDT