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ClinicalTrials.gov public records Last synced May 21, 2026, 2:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 274 matching trials from the local directory fallback.
Local D1 index available.
Filters: Condition: Abuse Clear all
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Child Abuse, Child Welfare, Consensus, Decision Making, Decision Making, Shared, Decision Support Technique, Family, Implementation Science, Mental Health, Organizations, Policy, Social Facilitation
Interventions
Optimizing Responses with Collaborative Assessments-Automated (ORCA-A), Optimizing Responses with Collaborative Assessments-Live (ORCA-L)
Behavioral
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced May 20, 2026, 10:46 AM EDT
Recruiting Phase 3 Interventional
View directory record Official record
Conditions
Methamphetamine Abuse, Methamphetamine-dependence
Interventions
extended release bupropion (BUP-XL) tablets (BUP-XL), extended-release naltrexone (XR-NTX), iPLB, oPLB
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
360 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
11
States / cities
Little Rock, Arkansas • Los Angeles, California • San Diego, California + 8 more
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced May 18, 2026, 3:10 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Drug Abuse, Nicotine Dependence
Interventions
MagPro X100 Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner, Transcranial Rotating Magnetic Stimulator
Device
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 80 Years
Enrollment
1,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced May 21, 2026, 1:18 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Substance Abuse
Interventions
Getting to Outcomes, Project ALERT
Behavioral
Lead sponsor
RAND
Other
Eligibility
11 Years to 70 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced May 20, 2026, 11:44 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Abuse Liability, Cannabis, Experimental Pain in Healthy Human Participants
Interventions
Active Inhaled Cannabis, Cannabidiol, Higher Dose, Cannabidiol, Medium Dose, Placebo Cannabidiol, Placebo Inhaled Cannabis
Drug
Lead sponsor
Hannah Harris
Other
Eligibility
18 Years to 55 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced May 19, 2026, 7:10 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Addiction, Addiction, Substance, Cannabis Abuse, Cannabis Abuse, Episodic Use, Cannabis Abuse, in Remission, Cannabis Dependence, Cannabis Intoxication, Cannabis Smoking, Cannabis Use, Cannabis Use Disorder, Cannabis Withdrawal, Cannabis-Related Disorder, Marijuana, Marijuana Abuse, Marijuana Dependence, Marijuana Smoking, Marijuana Use, Marijuana Use Disorder, Marijuana User, Marijuana-Related Disorder, Substance Abuse, Substance Abuse Drug Chronic, Substance Dependence, Substance Related Problem, Substance Use, Substance Use Disorders
Interventions
Contingency Management, Elastic Net Regression
Behavioral · Device
Lead sponsor
Indiana University
Other
Eligibility
14 Years to 17 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced May 21, 2026, 2:23 AM EDT
Recruiting Phase 3 Interventional
View directory record Official record
Conditions
Opioid Use, Polysubstance Abuse, Tobacco Use
Interventions
MORE and MI and NRT, MORE and No MI and NRT, Support Group and MI and NRT, Support Group and No MI and NRT
Other
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
2
States / cities
New Brunswick, New Jersey • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced May 20, 2026, 8:53 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Drinking, Alcohol Use Disorder, Military Family, Relations, Interpersonal
Interventions
CRAFT Web-Based Intervention, CRAFT Workbook, Gottman Self-Guided Resources, Phone-Based CRAFT
Behavioral
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
744 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2026 · Synced May 20, 2026, 3:12 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Anxiety, Depression, HIV Infections, Intimate Partner Violence (IPV), Substance Abuse
Interventions
SER Familia
Behavioral
Lead sponsor
Duke University
Other
Eligibility
12 Years to 100 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced May 20, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Use Disorder, Substance Use Disorders, Substance Use Disorders Alcohol Use Withdrawal State
Interventions
Sparrow Ascent, Sparrow Ascent (Sham)
Device
Lead sponsor
Spark Biomedical, Inc.
Industry
Eligibility
18 Years to 64 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced May 20, 2026, 11:44 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Opioid Abuse and Addiction
Interventions
1 Nalmefene implant, 2 Nalmefene implants
Drug
Lead sponsor
ReacX Pharmaceuticals, Inc.
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Morrisville, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 5, 2026 · Synced May 21, 2026, 2:23 AM EDT
Recruiting Phase 2 Interventional
View directory record Official record
Conditions
Methamphetamine Abuse, Substance Use, Substance Use Disorders
Interventions
Ketamine Hydrochloride, Midazolam Hydrochloride
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
5
States / cities
San Leandro, California • Albuquerque, New Mexico • New York, New York + 2 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced May 20, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Human Immunodeficiency Virus (HIV), Substance Abuse, Substance Addiction, Substance Use (Drugs, Alcohol), Substance Use Disorder (SUD)
Interventions
The TLC Program
Behavioral
Lead sponsor
Illinois Institute of Technology
Other
Eligibility
18 Years and older
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced May 20, 2026, 11:44 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Alcohol Abuse, Alcohol Abuse/Dependence, Alcohol Addiction, Alcohol Dependence, Alcohol Use Disorder, Alcoholism
Interventions
Deep TMS (DTMS), Sham (No Treatment)
Device
Lead sponsor
Brainsway
Industry
Eligibility
18 Years to 86 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
8
States / cities
Tuscaloosa, Alabama • La Jolla, California • West Palm Beach, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced May 20, 2026, 3:12 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Child Abuse, Child Neglect, Father-Child Relations, Fathers, Substance Use
Interventions
Case Management, Contingency Management, HERO Dads Fatherhood Program, Motivational Enhancement
Behavioral
Lead sponsor
Montefiore Medical Center
Other
Eligibility
18 Years and older · Male only
Enrollment
240 participants
Timeline
2023 – 2027
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Apr 22, 2026, 8:41 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Abuse Tobacco, Exposure
Interventions
Behavioral Intervention, Biospecimen Collection, Survey Administration
Behavioral · Other
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years to 29 Years
Enrollment
300 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced May 18, 2026, 9:44 AM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Abuse, Drug, Pain
Interventions
Active Cannabis, Placebo Cannabis
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 55 Years
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 19, 2026 · Synced May 8, 2026, 3:54 AM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Drug Use, Mental Illness, Substance Abuse
Interventions
Integrated Harm Reduction Intervention (IHRI)
Behavioral
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
3
States / cities
New Haven, Connecticut • New York, New York • Orangeburg, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2026 · Synced May 18, 2026, 5:15 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Decision Making, Decision Making, Shared, Implementation Science, Organizations, Policy, Substance Abuse, Substance-related Disorders
Interventions
Co-Design Sessions (CDS), Data products
Other
Lead sponsor
Chestnut Health Systems
Other
Eligibility
18 Years and older
Enrollment
341 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 15, 2026 · Synced May 19, 2026, 8:32 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Complex Medical Patients, Opioid Dependence, Primary Care Patients With Chronic Conditions, Substance Abuse Disorders
Interventions
MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 24, 2026 · Synced May 19, 2026, 8:11 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Cocaine Use, Cocaine Use Disorder, Methamphetamine Abuse, Methamphetamine-dependence, Opioid Use, Opioid-use Disorder, Substance Use
Interventions
App-Based Contingency Management, Sham Control
Behavioral
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Oconomowoc, Wisconsin • Wauwatosa, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced May 19, 2026, 8:11 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Abuse Opioids, Analgesia, Pain
Interventions
Buccal Buprenorphine 300 mcg, Buccal Buprenorphine 450mcg, Buccal Buprenorphine 600 mcg, Buccal Buprenorphine 900 mcg, Buccal Placebo, Oral Placebo, Oral immediate-release oxycodone 10mg
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jan 11, 2026 · Synced May 11, 2026, 9:14 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers
View directory record Official record
Conditions
Abuse, Drug, Intoxication; Cannabinoids, Pain
Interventions
Cannabis, Dronabinol, Oral Placebo, Smoked Placebo
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 65 Years
Enrollment
103 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced May 3, 2026, 11:56 PM EDT
Recruiting Not applicable Interventional
View directory record Official record
Conditions
Alcoholism, Depression, Drug Abuse
Interventions
Bipolar-Specific Cognitive Behavioral Therapy (CBT), Interpersonal and Social Rhythm Therapy (ISRT), Mindfulness-Based Stress Reduction (MBSR), Psycho-education & Understanding Bipolar Medications Therapy
Behavioral
Lead sponsor
Emory University
Other
Eligibility
18 Years to 64 Years
Enrollment
130 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2026
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced May 21, 2026, 1:18 AM EDT