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Showing 1–24 of 81 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Amblyopia Clear all
Completed Phase 3 Interventional

Trial Comparing Near Versus Distance Activities While Patching for Amblyopia in Children 3 to <7 Years Old

NCT00315198
View directory record Official record
Conditions
Amblyopia
Interventions
Eye Patch, Near activities, Distance activities
Device · Procedure
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
3 Years to 6 Years
Enrollment
425 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
2
States / cities
Bloomington, Indiana • Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 23, 2010 · Synced Jul 21, 2026, 11:20 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Vision In Preschoolers Study (VIP Study)

NCT00038753
View directory record Official record
Conditions
Amblyopia, Strabismus, Refractive Error
Interventions
Vision Screening
Procedure
Lead sponsor
National Eye Institute (NEI)
NIH
Eligibility
36 Months to 59 Months
Healthy volunteers
Accepts healthy volunteers
U.S. locations
5
States / cities
Berkeley, California • Boston, Massachusetts • Columbus, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Oct 15, 2009 · Synced Jul 21, 2026, 11:20 AM EDT
Terminated Phase 3 Interventional Results available

Trial Comparing Patching With Active Vision Therapy to Patching With Control Vision Therapy as Treatment for Amblyopia

NCT00587171
View directory record Official record
Conditions
Amblyopia
Interventions
Patching, Near activities, Active vision therapy, Control vision therapy
Device · Procedure
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
7 Years to 12 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
7
States / cities
Birmingham, Alabama • Miami, Florida • Bloomington, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Jul 21, 2026, 11:20 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

Amblyopia and Strabismus Detection Using Retinal Birefringence Imaging

NCT03919708
View directory record Official record
Conditions
Amblyopia, Strabismus
Interventions
Retinal Birefringence Imager
Device
Lead sponsor
Rebiscan, Inc.
Industry
Eligibility
2 Years to 8 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 17, 2023 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Not applicable Interventional

Luminopia One Pilot Study

NCT02782117
View directory record Official record
Conditions
Amblyopia
Interventions
Luminopia One
Device
Lead sponsor
Luminopia
Industry
Eligibility
4 Years to 12 Years
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
9
States / cities
Maitland, Florida • Chicago, Illinois • Bloomington, Indiana + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2020 · Synced Jul 21, 2026, 11:20 AM EDT
Recruiting Not applicable Interventional

Novel Amblyopia Treatment With Virtual Reality Games

NCT06049459
View directory record Official record
Conditions
Amblyopia
Interventions
Optical Correction, Therapeutic Dichoptic Virtual Reality Games
Device
Lead sponsor
Marjean Kulp
Other
Eligibility
5 Years to 17 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 21, 2025 · Synced Jul 21, 2026, 11:20 AM EDT
Withdrawn Not applicable Interventional

Assuring Ophthalmologic Follow up

NCT04959422
View directory record Official record
Conditions
Vision Screening, Amblyopia
Interventions
Active scheduling
Other
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
2 Years to 6 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Jul 21, 2026, 11:20 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Valproate for the Treatment of Residual Amblyopia

NCT07226141
View directory record Official record
Conditions
Amblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia Strabismic
Interventions
Valproate, Placebo, Patch
Drug · Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
8 Years to 17 Years
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Waltham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Phase 3 Interventional Results available

Full-time Bangerter Filters Versus Part-time Daily Patching for Moderate Amblyopia in Children

NCT00525174
View directory record Official record
Conditions
Amblyopia
Interventions
Bangerter filters, Patching, Near activities
Device · Procedure
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
3 Years to 9 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Jul 21, 2026, 11:20 AM EDT
Recruiting Not applicable Interventional

Video Treatment for Amblyopia

NCT05439200
View directory record Official record
Conditions
Amblyopia
Interventions
Asynchronous 3D movies, Patching
Device
Lead sponsor
Retina Foundation of the Southwest
Other
Eligibility
3 Years to 7 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Jul 21, 2026, 11:20 AM EDT
Completed No phase listed Observational

Gocheck Kids vs. Welch Allyn Spot Vision Screener

NCT04321538
View directory record Official record
Conditions
Amblyopia
Interventions
Gocheck Kids, Welch Allyn Spot Vision Screener, Physical Exam
Device · Diagnostic Test
Lead sponsor
Yale University
Other
Eligibility
1 Year to 7 Years
Enrollment
227 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 28, 2023 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Not applicable Interventional Results available

Binocular Dig Rush Game Treatment for Amblyopia

NCT02983552
View directory record Official record
Conditions
Amblyopia
Interventions
iPad®, Spectacle correction
Other
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
4 Years to 12 Years
Enrollment
320 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2020
U.S. locations
61
States / cities
Birmingham, Alabama • Glendale, Arizona • Anaheim, California + 49 more
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 21, 2026, 11:20 AM EDT
Active, not recruiting Not applicable Interventional

Binocular iPad Sub-Study

NCT02365090
View directory record Official record
Conditions
Amblyopia
Interventions
patching, binocular games
Other
Lead sponsor
Retina Foundation of the Southwest
Other
Eligibility
4 Years to 14 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 1, 2025 · Synced Jul 21, 2026, 11:20 AM EDT
Recruiting Phase 3 Interventional

Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

NCT06380517
View directory record Official record
Conditions
Amblyopia
Interventions
Luminopia, Eye Patch
Device · Other
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
4 Years to 7 Years
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
72
States / cities
Birmingham, Alabama • Glendale, Arizona • Scottsdale, Arizona + 58 more
Source: ClinicalTrials.gov public record
Updated Feb 10, 2026 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Not applicable Interventional

Dichoptic Video Treatment for Amblyopia

NCT03825107
View directory record Official record
Conditions
Amblyopia
Interventions
patching, Dichoptic videos
Other
Lead sponsor
Retina Foundation of the Southwest
Other
Eligibility
3 Years to 7 Years
Enrollment
65 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Jan 23, 2025 · Synced Jul 21, 2026, 11:20 AM EDT
Terminated Not applicable Interventional Results available

Comparison of AmblyzTM Glasses and Patching for Amblyopia

NCT01973348
View directory record Official record
Conditions
Amblyopia
Interventions
4-hour AmblyZ glasses, 12-hour AmblyZ glasses, 2-hour patching, 6-hour patching
Device
Lead sponsor
Indiana University
Other
Eligibility
3 Years to 8 Years
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Aug 24, 2017 · Synced Jul 21, 2026, 11:20 AM EDT
Completed No phase listed Observational

Performance of 2WIN Photoscreener With Corneal Reflex Compared to School Bus Retinoscopy by AAPOS Guidelines

NCT03668067
View directory record Official record
Conditions
Refractive Errors, Amblyopia, Strabismus, Development Delay
Interventions
2WIN photoscreener
Device
Lead sponsor
Alaska Blind Child Discovery
Other
Eligibility
1 Week to 90 Years
Enrollment
471 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Jan 29, 2024 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

NCT03109314
View directory record Official record
Conditions
Amblyopia
Interventions
Donepezil, Single-letter training, Uncrowd training
Drug · Behavioral
Lead sponsor
Dennis Levi
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Jan 16, 2019 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Phase 3 Interventional

Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia

NCT00000170
View directory record Official record
Conditions
Amblyopia
Interventions
Atropine, Eye Patch
Drug · Device
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
Up to 6 Years
Enrollment
419 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2013
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 5, 2014 · Synced Jul 21, 2026, 11:20 AM EDT
Not listed Not applicable Interventional

OCT Eccentric Fixation and Amblyopia in Children

NCT05714449
View directory record Official record
Conditions
Amblyopia
Interventions
eye patch, After-image and MIT trainer
Device
Lead sponsor
State University of New York College of Optometry
Other
Eligibility
4 Years to 16 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 22, 2024 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Phase 4 Interventional

Trial Comparing Daily Atropine Versus Weekend Atropine

NCT00094614
View directory record Official record
Conditions
Amblyopia
Interventions
Atropine
Drug
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
3 Years to 7 Years
Enrollment
168 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2003
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 24, 2010 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Active Approach to Treat Amblyopia: Perceptual Learning and Video Games

NCT01115283
View directory record Official record
Conditions
Amblyopia
Interventions
Perceptual learning, Video Games, Occlusion therapy
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
5 Years to 75 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
Berkeley, California
Source: ClinicalTrials.gov public record
Updated Nov 13, 2022 · Synced Jul 21, 2026, 11:20 AM EDT
Completed Phase 2 Interventional Results available

Pilot Study to Evaluate Levodopa as Treatment for Residual Amblyopia

NCT00789672
View directory record Official record
Conditions
Amblyopia
Interventions
levodopa/carbidopa, patching
Drug · Device
Lead sponsor
Jaeb Center for Health Research
Other
Eligibility
8 Years to 17 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 12, 2016 · Synced Jul 21, 2026, 11:20 AM EDT
Completed No phase listed Observational

Comparative Validation of "Blinq" and "2WIN" Vision Screeners

NCT04195711
View directory record Official record
Conditions
Strabismic Amblyopia, Refractive Amblyopia, Strabismus
Interventions
objective pediatric vision screen, "blinq,"
Diagnostic Test
Lead sponsor
Alaska Blind Child Discovery
Other
Eligibility
1 Year to 65 Years
Enrollment
100 participants
Timeline
2019
U.S. locations
1
States / cities
Anchorage, Alaska
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jul 21, 2026, 11:20 AM EDT