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ClinicalTrials.gov public records Last synced Sep 17, 2026, 11:06 AM EDT

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Showing 1–24 of 32 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Apnea of Prematurity Clear all
Recruiting Not applicable Interventional

Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates

NCT06849596
View directory record Official record
Conditions
Neonatal Resuscitation, Apnea Neonatal
Interventions
Ventilator derived positive pressure ventilation - V-PPV, T-piece resuscitator (TPR)
Device
Lead sponsor
Michelle Baczynski
Other
Eligibility
25 Weeks to 29 Weeks
Enrollment
780 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2026 · Synced Sep 17, 2026, 11:06 AM EDT
Terminated Not applicable Interventional

Early Versus Late Caffeine for ELBW Newborns

NCT02524249
View directory record Official record
Conditions
Bronchopulmonary Dysplasia, Apnea of Prematurity
Interventions
Caffeine, Placebo (dextrose)
Drug
Lead sponsor
Wayne State University
Other
Eligibility
Up to 4 Weeks
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 1, 2022 · Synced Sep 17, 2026, 11:06 AM EDT
Completed No phase listed Observational

Effect of Feedings on Caffeine in Premature Infants

NCT02293824
View directory record Official record
Conditions
Apnea of Prematurity, Premature Newborn, Caffeine
Interventions
Caffeine
Drug
Lead sponsor
Duke University
Other
Eligibility
Up to 15 Days
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
2
States / cities
Chapel Hill, North Carolina • Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 12, 2017 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

Non-invasive Intervention for Apnea of Prematurity

NCT02641249
View directory record Official record
Conditions
Apnea of Prematurity, Hypoxia, Bradycardia
Interventions
Vibration
Device
Lead sponsor
University of California, Los Angeles
Other
Eligibility
1 Week and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
2
States / cities
Los Angeles, California • Santa Monica, California
Source: ClinicalTrials.gov public record
Updated May 8, 2017 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Non-Invasive Neurally Adjusted Ventilatory Assist (NAVA) Prone vs Supine in Premature Infants

NCT05968586
View directory record Official record
Conditions
Neonatal Oxygen Desaturation, Premature, Ventilator Lung; Newborn, Apnea of Prematurity
Interventions
Body positioning
Other
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
1 Minute to 3 Months
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Sep 17, 2026, 11:06 AM EDT
Terminated Phase 3 Interventional Results available

Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial

NCT03340727
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
Caffeine Citrate, Placebo
Drug
Lead sponsor
NICHD Neonatal Research Network
Network
Eligibility
29 Weeks to 33 Weeks
Enrollment
827 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
16
States / cities
Birmingham, Alabama • Palo Alto, California • Atlanta, Georgia + 12 more
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Sep 17, 2026, 11:06 AM EDT
Active, not recruiting Phase 2 Interventional

Caffeine Use in the Management of Preterm Infants

NCT06327152
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
Caffeine, Sterile Water Placebo
Drug · Other
Lead sponsor
University of California, Irvine
Other
Eligibility
1 Week to 40 Weeks
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Orange, California
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Phase 1 Interventional Results available

Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study

NCT00296231
View directory record Official record
Conditions
Infant Respiratory Distress Syndrome, Respiratory Insufficiency, Apnea of Prematurity
Interventions
Nasal high frequency ventilation
Other
Lead sponsor
Tarah T Colaizy
Other
Eligibility
7 Days to 3 Months
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Feb 8, 2018 · Synced Sep 17, 2026, 11:06 AM EDT
Recruiting Phase 1 Interventional

Pharmacokinetics and Placental Transfer of Caffeine

NCT07570121
View directory record Official record
Conditions
Preterm Labor With Preterm Delivery, Premature Birth, Apnea of Prematurity, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Interventions
Caffeine citrate
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 3

NCT03333174
View directory record Official record
Conditions
Infant,Premature
Interventions
Cardiorespiratory monitoring
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 98 Days
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants

NCT03298035
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
NCPAP as mode for apnea prevention, NIPPV as rescue mode for apnea prevention
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 6, 2020 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Phase 4 Interventional Results available

MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine

NCT00809055
View directory record Official record
Conditions
Apnea of Prematurity, Intraventricular Hemorrhage, Brain Injury
Interventions
Caffeine citrate
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
24 Weeks to 30 Weeks
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2015
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 23, 2016 · Synced Sep 17, 2026, 11:06 AM EDT
Completed No phase listed Observational

Prematurity-Related Ventilatory Control

NCT03464396
View directory record Official record
Conditions
Respiratory Control in Premature Infants
Interventions
Bedside Physiology study, Carotid Body Function Test, Room Air Challenge, Hypoxia Challenge Test, Effects of Nasal Cannula Flow, Magnetic Resonance Imaging, Echocardiogram, Blood Sample
Other · Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
1 Day to 28 Days
Enrollment
177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jan 30, 2023 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Phase 3 Interventional Results available

Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm

NCT01875159
View directory record Official record
Conditions
Hypoxia
Interventions
Caffeine citrate 6 mg/kg/day
Drug
Lead sponsor
American SIDS Institute
Other
Eligibility
33 Weeks to 37 Weeks
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Sep 17, 2026, 11:06 AM EDT
Not listed Not applicable Interventional

Evaluating Pressures During Non-invasive Ventilation Utilizing NIV Plus Software

NCT05961683
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Apnea of Newborn
Interventions
NIV plus software
Device
Lead sponsor
Keck School of Medicine of USC
Other
Eligibility
0 Days to 30 Days
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 26, 2023 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional

Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 2

NCT03333161
View directory record Official record
Conditions
Infant,Premature
Interventions
Cardiorespiratory monitoring
Diagnostic Test
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
1 Day to 15 Days
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Sep 20, 2021 · Synced Sep 17, 2026, 11:06 AM EDT
Completed No phase listed Observational

The Effect of Standardizing the Definition of a Clinically Significant Cardiopulmonary Event on Length of Stay

NCT03414671
View directory record Official record
Conditions
Apnea of Prematurity
Interventions
Not listed
Lead sponsor
Pediatrix
Other
Eligibility
23 Weeks to 29 Weeks
Enrollment
160 participants
Timeline
2018 – 2021
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 3, 2021 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Phase 4 Interventional Results available

Apnea in Hospitalized Preterm Infants Following the Administration of Routine Childhood Vaccines

NCT03530124
View directory record Official record
Conditions
Apnea, Apnea Neonatal, Prematurity
Interventions
PCV13, DTaP, HBV, IPV, Hib
Biological
Lead sponsor
Duke University
Other
Eligibility
6 Weeks and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
4
States / cities
Atlanta, Georgia • Chapel Hill, North Carolina • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 17, 2026, 11:06 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Study of Erythromycin in GER-Associated Apnea of the Newborn

NCT01825473
View directory record Official record
Conditions
Gastroesophageal Reflux, Apnea, Bradycardia
Interventions
Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring, Placebo (D5W)
Drug · Device
Lead sponsor
University of Virginia
Other
Eligibility
14 Days and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 4, 2013 · Synced Sep 17, 2026, 11:06 AM EDT
Not listed Phase 4 Interventional

Early Caffeine in Preterm Neonates

NCT03086473
View directory record Official record
Conditions
BPD - Bronchopulmonary Dysplasia, Apnea of Prematurity, Hemodynamic Instability, Intubation
Interventions
Caffeine Citrate, Placebo (Normal Saline)
Drug
Lead sponsor
Jennifer Shepherd
Other
Eligibility
Up to 1 Day
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
2
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Aug 2, 2021 · Synced Sep 17, 2026, 11:06 AM EDT
Recruiting No phase listed Observational

Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

NCT05336890
View directory record Official record
Conditions
Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders
Interventions
Not listed
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
30 Weeks to 83 Months
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 14, 2026 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation

NCT03292562
View directory record Official record
Conditions
Apnea of Prematurity, Respiratory Distress Syndrome
Interventions
Discontinue NCPAP after weaning pressures, Discontinue NCPAP without weaning pressures
Device
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
Not listed
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2020 · Synced Sep 17, 2026, 11:06 AM EDT
Terminated Not applicable Interventional Results available

Caffeine to Reduce Mechanical Ventilation in Preterm Infants

NCT01751724
View directory record Official record
Conditions
Prematurity, Apnea, Respiratory Failure
Interventions
Caffeine citrate, Normal saline
Drug · Other
Lead sponsor
University of Miami
Other
Eligibility
1 Day to 5 Days
Enrollment
87 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Sep 17, 2026, 11:06 AM EDT
Completed Phase 3 Interventional Results available

Armodafinil (Nuvigil), Postoperative Recovery of OSA (Obstructive Sleep Apnea) and Obese Patients

NCT02478580
View directory record Official record
Conditions
Obesity, Premature Recovery From Anesthesia
Interventions
Nuvigil, Placebo
Drug
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Dec 3, 2018 · Synced Sep 17, 2026, 11:06 AM EDT